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    APOM apolipoprotein M [ Homo sapiens (human) ]

    Gene ID: 55937, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Plasma apolipoprotein M predicts overall survival in metastatic breast cancer patients.

    Plasma apolipoprotein M predicts overall survival in metastatic breast cancer patients.
    Muendlein A, Heinzle C, Brandtner EM, Leiherer A, Geiger K, Gaenger S, Drexel H, Dechow T, Decker T.

    08/30/2023
    ApoM suppresses kidney renal clear cell carcinoma growth and metastasis via the Hippo-YAP signaling pathway.

    ApoM suppresses kidney renal clear cell carcinoma growth and metastasis via the Hippo-YAP signaling pathway.
    Xu T, Wei D, Yang Z, Xie S, Yan Z, Chen C, Hu W, Shi Z, Zhao Y, Cui M, Xu Z, Wang J.

    07/12/2023
    Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans.

    Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans.
    Borup A, Donkin I, Boon MR, Frydland M, Martinez-Tellez B, Loft A, Keller SH, Kjaer A, Kjaergaard J, Hassager C, Barrès R, Rensen PCN, Christoffersen C., Free PMC Article

    11/12/2022
    Regulation of the apolipoprotein M signaling pathway: a review.

    Regulation of the apolipoprotein M signaling pathway: a review.
    Cheng G, Zheng L.

    06/11/2022
    The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells.

    The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells.
    Zhou Y, Yao S, Yu M, Wei J, Fang Q, Xu N, Luo G.

    04/2/2022
    Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.

    Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 Promote the Transendothelial Transport of High-Density Lipoprotein.
    Velagapudi S, Rohrer L, Poti F, Feuerborn R, Perisa D, Wang D, Panteloglou G, Potapenko A, Yalcinkaya M, Hülsmeier AJ, Hesse B, Lukasz A, Liu M, Parks JS, Christoffersen C, Stoffel M, Simoni M, Nofer JR, von Eckardstein A., Free PMC Article

    11/27/2021
    Apolipoprotein M Gene Polymorphism Rs805297 (C-1065A): Association With Type 2 Diabetes Mellitus and Related Microvascular Complications in South Egypt.

    Apolipoprotein M Gene Polymorphism Rs805297 (C-1065A): Association With Type 2 Diabetes Mellitus and Related Microvascular Complications in South Egypt.
    Tageldeen MM, Badrawy H, Abdelmeguid M, Zaghlol M, Gaber N, Kenawy EM.

    07/24/2021
    Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.

    Comprehensive lipidomics in apoM(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.
    Shi Y, Lam SM, Liu H, Luo G, Zhang J, Yao S, Li J, Zheng L, Xu N, Zhang X, Shui G.

    07/10/2021
    Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure.

    Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure.
    Chirinos JA, Zhao L, Jia Y, Frej C, Adamo L, Mann D, Shewale SV, Millar JS, Rader DJ, French B, Brandimarto J, Margulies KB, Parks JS, Wang Z, Seiffert DA, Fang J, Sweitzer N, Chistoffersen C, Dahlbäck B, Car BD, Gordon DA, Cappola TP, Javaheri A., Free PMC Article

    06/12/2021
    Apolipoprotein M, identified as a novel hepatitis C virus (HCV) particle associated protein, contributes to HCV assembly and interacts with E2 protein.

    Apolipoprotein M, identified as a novel hepatitis C virus (HCV) particle associated protein, contributes to HCV assembly and interacts with E2 protein.
    Cai H, Yao W, Huang J, Xiao J, Chen W, Hu L, Mai R, Liang M, Chen D, Jiang N, Zhou L, Peng T.

    04/3/2021
    LncRNA HCG11 suppresses laryngeal carcinoma cells progression via sponging miR-4469/APOM axis.

    LncRNA HCG11 suppresses laryngeal carcinoma cells progression via sponging miR-4469/APOM axis.
    Xue HX, Li HF, Wang T, Li WJ, Bian WC.

    03/20/2021
    Apolipoprotein M and Risk of Type 2 Diabetes.

    Apolipoprotein M and Risk of Type 2 Diabetes.
    Hajny S, Christoffersen M, Dalila N, Nielsen LB, Tybjærg-Hansen A, Christoffersen C.

    02/27/2021
    Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility.

    Interaction Between Apolipoprotein M Gene Single-Nucleotide Polymorphisms and Obesity and its Effect on Type 2 Diabetes Mellitus Susceptibility.
    Liu D, Pan JM, Pei X, Li JS., Free PMC Article

    12/5/2020
    Systemic lupus erythematosus patients had decreased levels of plasma apolipoprotein M compared to healthy controls.

    Low plasma concentrations of apolipoprotein M are associated with disease activity and endothelial dysfunction in systemic lupus erythematosus.
    Tydén H, Lood C, Jönsen A, Gullstrand B, Kahn R, Linge P, Kumaraswamy SB, Dahlbäck B, Bengtsson AA., Free PMC Article

    05/16/2020
    Serum ApoM was elevated in IgA vasculitis (lgAV) patients and decreased gradually with the ISKDC grading score. ApoM was identified as a protective factor for nephritis in all lgAV patients.

    Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis.
    Wu J, He L, Bai L, Tan L, Hu M., Free PMC Article

    05/9/2020
    menopause accompanied by higher plasma concentration

    Effect of menopause and exercise training on plasma apolipoprotein M and sphingosine-1-phosphate.
    Yafasova A, Mandrup CM, Egelund J, Nyberg M, Stallknecht B, Hellsten Y, Nielsen LB, Christoffersen C.

    03/14/2020
    In obese individuals, calorie restriction increased adipose tissue APOM expression and secretion.

    Apolipoprotein M: a novel adipokine decreasing with obesity and upregulated by calorie restriction.
    Sramkova V, Berend S, Siklova M, Caspar-Bauguil S, Carayol J, Bonnel S, Marques M, Decaunes P, Kolditz CI, Dahlman I, Arner P, Stich V, Saris WHM, Astrup A, Valsesia A, Rossmeislova L, Langin D, Viguerie N.

    02/8/2020
    niacin treatment resulted in increased ApoM gene and protein expression levels in mice. In conclusion, niacin upregulates ApoM expression by increasing LXRalpha expression in vivo and in vitro.

    Niacin regulates apolipoprotein M expression via liver X receptor‑α.
    Yang L, Li T, Zhao S, Zhang S., Free PMC Article

    02/8/2020
    Plasma APOM levels were reduced in patients with chronic kidney disease stages 3-5D and this was mainly due to differences in plasma HDL-cholesterol.

    Apolipoprotein M in patients with chronic kidney disease.
    Sørensen IM, Bertelsen M, Freese E, Lindhard K, Ullum H, Feldt-Rasmussen B, Nielsen LB, Christoffersen C, Bro S.

    10/26/2019
    \the results demonstrate that apoM-S1P inhibits ox-LDL-induced inflammation in HUVECs via the S1PR2-mediated PI3K/Akt signaling pathway.

    ApoM-S1P Modulates Ox-LDL-Induced Inflammation Through the PI3K/Akt Signaling Pathway in HUVECs.
    Zheng Z, Zeng Y, Zhu X, Tan Y, Li Y, Li Q, Yi G.

    08/3/2019
    Study shows that high-density lipoproteins (HDL) promotes increased export of sphingosine-1-phosphate (S1P) from human erythrocytes and that this is further enhanced by the presence of apoM. Also, apoM induces S1P export from erythrocytes independently of binding to HDL particles.

    Apolipoprotein M mediates sphingosine-1-phosphate efflux from erythrocytes.
    Christensen PM, Bosteen MH, Hajny S, Nielsen LB, Christoffersen C., Free PMC Article

    07/20/2019
    he results demonstrated that CDCA and apoM may modulate TF isoforms in different cell lines, and suggested that asTF may serve a role in the pathophysiological mechanism underlying cervical cancer development. In conclusion, the TF isoforms serve important and distinct roles in pathophysiological processes

    Expression of flTF and asTF splice variants in various cell strains and tissues.
    Pan L, Yu Y, Yu M, Yao S, Mu Q, Luo G, Xu N., Free PMC Article

    05/25/2019
    These results suggested that PPARgamma regulates the S1P levels by modulating apoM in a bell-shaped manner, with the greatest levels of apoM/S1P observed when PPARgamma was mildly expressed and that hepatic apoM/PPARgamma axis might maintain the homeostasis of S1P metabolism.

    Regulation of the metabolism of apolipoprotein M and sphingosine 1-phosphate by hepatic PPARγ activity.
    Kurano M, Ikeda H, Iso-O N, Hara M, Tsukamoto K, Yatomi Y.

    04/6/2019
    apoM could be bound to high-density lipoprotein after secretion and then quickly exchanged with a non-lipoprotein-related compartment and to LDL to be slowly catabolized.

    Stable Isotope Kinetic Study of ApoM (Apolipoprotein M).
    Croyal M, Billon-Crossouard S, Goulitquer S, Aguesse A, León L, Fall F, Chétiveaux M, Moyon T, Blanchard V, Ouguerram K, Lambert G, Nobécourt E, Krempf M.

    02/2/2019
    Obese patients showed significantly lower plasmatic ApoM levels than people with normal body weight, and ApoM level showed a strong correlation with CRP, TNF-alpha, and IL-6 levels, which indicated that ApoM might be regulated by these inflammatory factors.

    Correlation Between Apolipoprotein M and Inflammatory Factors in Obese Patients.
    Li T, Yang L, Zhao S, Zhang S., Free PMC Article

    11/24/2018
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