| The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain. | The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.
Li X, Wang J, Liao C, Yang X, Zhao Z, Liu Y, Xue Q, Luo Y, Liu X, Liu Z. | 04/26/2024 |
| Cross talk of tumor protein D52 (TPD52) with KLF9, PKCepsilon, and MicroRNA 223 in ovarian cancer. | Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer.
Khan K, Zafar S, Badshah Y, Ashraf NM, Rafiq M, Danish L, Shabbir M, Trembley JH, Afsar T, Almajwal A, Razak S., Free PMC Article | 11/7/2023 |
| Effects of PKCepsilon knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo. | Effects of PKCε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo.
Xu Y, Tao J, Hou Y, Zhang S. | 09/29/2023 |
| Apolipoprotein E epsilon4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCepsilon mislocalization in cholinergic neuronal cells. | Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells.
Piccarducci R, Giacomelli C, Bertilacchi MS, Benito-Martinez A, Di Giorgi N, Daniele S, Signore G, Rocchiccioli S, Vilar M, Marchetti L, Martini C. | 08/9/2023 |
| Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma. | Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma.
Rehman A, Shabbir M, Badshah Y, Khan K, Trembley JH, Ashraf NM, Afsar T, Almajwal A, Alruwaili NW, Alshamari A, Alanezi TN, Razak S., Free PMC Article | 02/16/2023 |
| Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2. | Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2.
Lai X, Liang Y, Jin J, Zhang H, Wu Z, Li G, Wang J, Zhang Z, Chen H, Zeng F, Deng F. | 01/14/2023 |
| Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters. | Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.
Pan X, Wu Y, Peng H, Cai X, Hu Z, Lin X, Peng XE. | 05/14/2022 |
| PKCepsilon regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells. | PKCε regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells.
Cooke M, Baker MJ, Kazanietz MG, Casado-Medrano V., Free PMC Article | 02/12/2022 |
| A genetically-encoded crosslinker screen identifies SERBP1 as a PKCepsilon substrate influencing translation and cell division. | A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division.
Martini S, Davis K, Faraway R, Elze L, Lockwood N, Jones A, Xie X, McDonald NQ, Mann DJ, Armstrong A, Ule J, Parker PJ., Free PMC Article | 01/8/2022 |
| Role of PKCepsilon in the epithelial-mesenchymal transition induced by FGFR2 isoform switch. | Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switch.
Ranieri D, Nanni M, Persechino F, Torrisi MR, Belleudi F., Free PMC Article | 08/14/2021 |
| PKCepsilon associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner. | PKCε associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner.
Zemel BM, Zhi L, Brown EV, Tymanskyj SR, Liang Q, Covarrubias M. | 06/19/2021 |
| Overexpression of microRNA-205-5p exerts suppressive effects on stem cell drug resistance in gallbladder cancer by down-regulating PRKCE. | Overexpression of microRNA-205-5p exerts suppressive effects on stem cell drug resistance in gallbladder cancer by down-regulating PRKCE.
Zhang GF, Wu JC, Wang HY, Jiang WD, Qiu L., Free PMC Article | 04/3/2021 |
| PKCepsilon Is Required for KRAS-Driven Lung Tumorigenesis. | PKCε Is Required for KRAS-Driven Lung Tumorigenesis.
Garg R, Cooke M, Benavides F, Abba MC, Cicchini M, Feldser DM, Kazanietz MG., Free PMC Article | 03/6/2021 |
| Regulation of Autophagy by Protein Kinase C-epsilon in Breast Cancer Cells. | Regulation of Autophagy by Protein Kinase C-ε in Breast Cancer Cells.
Basu A., Free PMC Article | 02/20/2021 |
| studies established a distinctive involvement of PKCepsilon in epithelial and mesenchymal NSCLC cells, and identified a complex interplay between PKCepsilon and small GTPases that contributes to regulation of NSCLC cell morphology and motile activity | Distinctive requirement of PKCε in the control of Rho GTPases in epithelial and mesenchymally transformed lung cancer cells.
Casado-Medrano V, Barrio-Real L, Wang A, Cooke M, Lopez-Haber C, Kazanietz MG., Free PMC Article | 02/15/2020 |
| Phosphorylation is a crucial post-translational modification of GAC, which is responsible for the higher glutaminase activity in lung tumor tissues and cancer cells. This study identified the key Ser314 phosphorylation site on GAC that is regulated by the NF-kappaB-protein kinase C epsilon axis. | Phosphorylation of glutaminase by PKCε is essential for its enzymatic activity and critically contributes to tumorigenesis.
Han T, Zhan W, Gan M, Liu F, Yu B, Chin YE, Wang JB., Free PMC Article | 10/5/2019 |
| This study uncovers a previously unrecognized role for PKCepsilon in supporting AML cell survival and disease progression by regulating mitochondrial ROS biology and positions mitochondrial redox regulators as potential therapeutic targets in AML | Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia.
Di Marcantonio D, Martinez E, Sidoli S, Vadaketh J, Nieborowska-Skorska M, Gupta A, Meadows JM, Ferraro F, Masselli E, Challen GA, Milsom MD, Scholl C, Fröhling S, Balachandran S, Skorski T, Garcia BA, Mirandola P, Gobbi G, Garzon R, Vitale M, Sykes SM., Free PMC Article | 07/27/2019 |
| PKCepsilon isoenzyme mediates the inhibitory action of Angiotensin II on slowly activating delayed rectifier K(+) curren and by phosphorylating distinct sites in KCNQ1/KCNE1, cPKC and PKCepsilon isoenzymes produce the contrary regulatory effects on the channel. | Protein kinase C epsilon mediates the inhibition of angiotensin II on the slowly activating delayed-rectifier potassium current through channel phosphorylation.
Gou X, Wang W, Zou S, Qi Y, Xu Y. | 06/29/2019 |
| A novel PKCepsilon function that promotes cell growth in prostate cancer cells by increasing aerobic glycolysis through crosstalk between PKCepsilon and Smad2/3. | Crosstalk of protein kinase C ε with Smad2/3 promotes tumor cell proliferation in prostate cancer cells by enhancing aerobic glycolysis.
Xu W, Zeng F, Li S, Li G, Lai X, Wang QJ, Deng F., Free PMC Article | 03/23/2019 |
| PKCepsilon interacts with Stat3 during Th17 differentiation and its overexpression results in an enhanced expression of Stat3 and pStat3(Ser727); conversely, when PKCepsilon is forcibly downregulated, CD4+ -T cells show lower levels of pStat3(Ser727) expression and defective in vitro expansion into the Th17-lineage. | PKCε promotes human Th17 differentiation: Implications in the pathophysiology of psoriasis.
Martini S, Pozzi G, Carubbi C, Masselli E, Galli D, Di Nuzzo S, Banchini A, Gobbi G, Vitale M, Mirandola P. | 01/26/2019 |
| Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review] | Protein kinase C as a tumor suppressor.
Newton AC., Free PMC Article | 11/3/2018 |
| PKCvarepsilon directly modulates the Aurora B-dependent abscission checkpoint by phosphorylating Aurora B at S227. This phosphorylation invokes a switch in Aurora B specificity, with increased phosphorylation of a subset of target substrates, including the CPC subunit Borealin. | PKCɛ switches Aurora B specificity to exit the abscission checkpoint.
Pike T, Brownlow N, Kjaer S, Carlton J, Parker PJ., Free PMC Article | 09/22/2018 |
| Results indicate an important role of protein kinase C epsilon (PKCepsilon) in autophagy and as a therapeutic target. | Impact of PKCε downregulation on autophagy in glioblastoma cells.
Toton E, Romaniuk A, Konieczna N, Hofmann J, Barciszewski J, Rybczynska M., Free PMC Article | 08/25/2018 |
| PKC epsilon, activated by DCP-LA, increases elastin and fibulin-5/DANCE in the extracellular space of cultured fibroblasts by the mechanism independent of transcriptional and translational modulation or inhibition of elastolysis. | PKCε Increases Extracellular Elastin and Fibulin-5/DANCE in Dermal Fibroblasts.
Nishizaki T. | 06/30/2018 |
| The downregulation of mi143 promoted cell proliferation by regulating PKCepsilon in the hepatocellular carcinoma cells. | Downregulation of microRNA-143 promotes cell proliferation by regulating PKCε in hepatocellular carcinoma cells.
Tang H, Li X, Yang R. | 05/19/2018 |