| CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma. | CDCA8 Facilitates Tumor Proliferation and Predicts a Poor Prognosis in Hepatocellular Carcinoma.
Cui Y, Jiang N. | 02/22/2024 |
| CDCA8 promotes bladder cancer survival by stabilizing HIF1alpha expression under hypoxia. | CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia.
Zhou Q, Huang W, Xiong J, Guo B, Wang X, Guo J., Free PMC Article | 11/6/2023 |
| Cell division cycle-associated 8 is a prognostic biomarker related to immune invasion in hepatocellular carcinoma. | Cell division cycle-associated 8 is a prognostic biomarker related to immune invasion in hepatocellular carcinoma.
Wu H, Liu S, Wu D, Zhou H, Sui G, Wu G., Free PMC Article | 05/12/2023 |
| A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis. | A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis.
Wu Y, Zeng S, Miao C, Wu H, Xu X, Chen L, Lu G, Lin G, Dai C. | 04/10/2023 |
| Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma. | Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma.
Guo R, Ying J, Jia L, Zhuang N, Jiang H, Xiong J. | 01/11/2023 |
| Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer. | Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer.
Yi Y, Li Y, Li C, Wu L, Zhao D, Li F, Fazli L, Wang R, Wang L, Dong X, Zhao W, Chen K, Cao Q., Free PMC Article | 07/23/2022 |
| MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8. | MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8.
Wang X, Zhu L, Lin X, Huang Y, Lin Z. | 02/12/2022 |
| Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology. | Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology.
Li Q, Liang J, Chen B., Free PMC Article | 11/13/2021 |
| Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma. | Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma.
Wang X, Wang H, Xu J, Hou X, Zhan H, Zhen Y., Free PMC Article | 09/25/2021 |
| Development and validation of hub genes for lymph node metastasis in patients with prostate cancer. | Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.
Xu N, Chen SH, Lin TT, Cai H, Ke ZB, Dong RN, Huang P, Li XD, Chen YH, Zheng QS., Free PMC Article | 05/1/2021 |
| The Correct Localization of Borealin in Midbody during Cytokinesis Depends on IQGAP1. | The Correct Localization of Borealin in Midbody during Cytokinesis Depends on IQGAP1.
Wumaier R, Aili A, Saiyin H, Zhang P, Cao L, Muheremu A., Free PMC Article | 04/17/2021 |
| KIF18B promotes the proliferation of pancreatic ductal adenocarcinoma via activating the expression of CDCA8. | KIF18B promotes the proliferation of pancreatic ductal adenocarcinoma via activating the expression of CDCA8.
Li B, Liu B, Zhang X, Liu H, He L. | 03/13/2021 |
| Borealin is a master regulator determining the chromosome association and function of the chromosome association of the chromosomal passenger complex | Borealin-nucleosome interaction secures chromosome association of the chromosomal passenger complex.
Abad MA, Ruppert JG, Buzuk L, Wear M, Zou J, Webb KM, Kelly DA, Voigt P, Rappsilber J, Earnshaw WC, Jeyaprakash AA., Free PMC Article | 06/6/2020 |
| These results indicate that CDCA8 is associated with bipolar spindle formation, chromosome segregation, PBE during human oocyte meiosis, and that it may affect the incidence of aneuploidy embryos in older women | CDCA8 regulates meiotic spindle assembly and chromosome segregation during human oocyte meiosis.
Zhang C, Zhao L, Leng L, Zhou Q, Zhang S, Gong F, Xie P, Lin G. | 04/25/2020 |
| Results indicate that higher CDCA8 expression in breast cancer cells is positively associated with poor prognosis and suggest that CDCA8 is a key mediator of estrogen-stimulated breast cancer cell growth and survival. | CDCA8 is a key mediator of estrogen-stimulated cell proliferation in breast cancer cells.
Bu Y, Shi L, Yu D, Liang Z, Li W. | 05/18/2019 |
| CDCA8 was overexpressed in cutaneous melanoma tissues and cells lines compared with normal tissues. | Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis.
Ci C, Tang B, Lyu D, Liu W, Qiang D, Ji X, Qiu X, Chen L, Ding W., Free PMC Article | 03/9/2019 |
| Results show that CDCA8 is overexpressed in bladder cancer (BC) and its high levels are correlated with poor clinicopathological features of BC patients. Therefore, CDCA8 may act as a novel prognostic marker in the diagnosis of patients with BC. | CDCA8 expression and its clinical relevance in patients with bladder cancer.
Bi Y, Chen S, Jiang J, Yao J, Wang G, Zhou Q, Li S., Free PMC Article | 09/8/2018 |
| These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans. | Mutations in BOREALIN cause thyroid dysgenesis.
Carré A, Stoupa A, Kariyawasam D, Gueriouz M, Ramond C, Monus T, Léger J, Gaujoux S, Sebag F, Glaser N, Zenaty D, Nitschke P, Bole-Feysot C, Hubert L, Lyonnet S, Scharfmann R, Munnich A, Besmond C, Taylor W, Polak M., Free PMC Article | 09/16/2017 |
| Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores. | Borealin dimerization mediates optimal CPC checkpoint function by enhancing localization to centromeres and kinetochores.
Bekier ME, Mazur T, Rashid MS, Taylor WR., Free PMC Article | 04/9/2016 |
| enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription. | Transcriptional activation of human CDCA8 gene regulated by transcription factor NF-Y in embryonic stem cells and cancer cells.
Dai C, Miao CX, Xu XM, Liu LJ, Gu YF, Zhou D, Chen LS, Lin G, Lu GX., Free PMC Article | 12/5/2015 |
| In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging. | Borealin/Dasra B is overexpressed in colorectal cancers and contributes to proliferation of cancer cells.
Wang Y, Zhao Z, Bao X, Fang Y, Ni P, Chen Q, Zhang W, Deng A. | 10/24/2015 |
| These findings reveal a previously unrecognized but direct link between HP1 and CPC localization in the centromere and illustrate the critical role of borealin-HP1 interaction in orchestrating an accurate cell division. | Chromatin protein HP1 interacts with the mitotic regulator borealin protein and specifies the centromere localization of the chromosomal passenger complex.
Liu X, Song Z, Huo Y, Zhang J, Zhu T, Wang J, Zhao X, Aikhionbare F, Zhang J, Duan H, Wu J, Dou Z, Shi Y, Yao X., Free PMC Article | 02/14/2015 |
| Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C. | The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis.
Capalbo L, Montembault E, Takeda T, Bassi ZI, Glover DM, D'Avino PP., Free PMC Article | 07/6/2013 |
| MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity. | MLL5 maintains genomic integrity by regulating the stability of the chromosomal passenger complex through a functional interaction with Borealin.
Liu J, Cheng F, Deng LW., Free PMC Article | 04/27/2013 |
| important role for phosphorylation of Borealin at S219 in the proper progression through mitosis | Regulation of Borealin by phosphorylation at serine 219.
Kaur H, Bekier ME, Taylor WR. | 04/2/2011 |