| Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis. | Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis.
Pereira M, Ribeiro DR, Berg M, Tsai AP, Dong C, Nho K, Kaiser S, Moutinho M, Soares AR. | 11/16/2023 |
| Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer. | Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer.
Barznegar M, Rahimi K, Mahdavi P, Menbari MN, Darvishi N, Vahabzadeh Z, Hakhamaneshi MS, Andalibi P, Abdi M. | 08/27/2022 |
| study reveals a novel regulatory mechanism for ELP3, provides an example that acetyltransferase itself can be regulated by PTM, and suggests a potential target for ALK-positive cancer therapies. | ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK).
Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, Yuan HX. | 03/21/2020 |
| Elongator activated migration and invasion of hepatocellular carcinoma cells by promoting the expression of MMP-2 and MMP-9 through the PI3K/AKT signaling pathway | Elongator promotes the migration and invasion of hepatocellular carcinoma cell by the phosphorylation of AKT.
Xu Y, Zhou W, Ji Y, Shen J, Zhu X, Yu H, Guo J, Pang Z, Wei W., Free PMC Article | 07/20/2019 |
| and CTU1/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio tRNA modification, are up-regulated in human breast cancers and sustain metastasis. | Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Florin A, Desmecht H, Desmet CJ, Nguyen L, Leidel SA, Willis AE, Büttner R, Chariot A, Close P., Free PMC Article | 08/5/2017 |
| Promoter hypermethylation is an important mechanism of the transcriptional inactivation of ELP3 in invasive ductal breast carcinoma. | Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma.
Wang D, Yang PN, Chen J, Zhou XY, Liu QJ, Li HJ, Li CL. | 10/10/2015 |
| Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. | Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.
Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D., Free PMC Article | 08/16/2014 |
| data suggest that hElp3 can regulate the transcription of HSP70 gene, and the HAT domain of hElp3 is essential for this function | hElp3 directly modulates the expression of HSP70 gene in HeLa cells via HAT activity.
Li F, Ma J, Ma Y, Hu Y, Tian S, White RE, Han G., Free PMC Article | 05/26/2012 |
| Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.
Perroud N, Uher R, Ng MY, Guipponi M, Hauser J, Henigsberg N, Maier W, Mors O, Gennarelli M, Rietschel M, Souery D, Dernovsek MZ, Stamp AS, Lathrop M, Farmer A, Breen G, Aitchison KJ, Lewis CM, Craig IW, McGuffin P. | 12/5/2010 |
| The results of this study uncover a novel role for Elp3 in the regulation of synaptic bouton expansion during neurogenesis that may be linked with a requirement for sleep. | The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila.
Singh N, Lorbeck MT, Zervos A, Zimmerman J, Elefant F., Free PMC Article | 11/27/2010 |
| Elp3 promotes the acetylation of alpha-tubulin in microtubules in neurological disorders. | Elongator - an emerging role in neurological disorders.
Nguyen L, Humbert S, Saudou F, Chariot A. | 05/3/2010 |
| ELP3 localises to mitochondria in HeLa cells, actin-like filaments, and actin-rich sites at the edges of spreading cells. This suggests that ELP3 and the ELONGATOR complex may play a role in mitochondrial function, actin organisation, and cell motility. | ELP3 localises to mitochondria and actin-rich domains at edges of HeLa cells.
Barton D, Braet F, Marc J, Overall R, Gardiner J. | 01/21/2010 |
| Allelic variants of ELP3 were associated with amyotrophic lateral sclerosis in three populations comprising 1483 people. | Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.
Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PW, Landers JE, Sapp P, Van Den Bosch L, Knight J, Neale BM, Turner MR, Veldink JH, Ophoff RA, Tripathi VB, Beleza A, Shah MN, Proitsi P, Van Hoecke A, Carmeliet P, Horvitz HR, Leigh PN, Shaw CE, van den Berg LH, Sham PC, Powell JF, Verstreken P, Brown RH Jr, Robberecht W, Al-Chalabi A, Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PW, Landers JE, Sapp P, Van Den Bosch L, Knight J, Neale BM, Turner MR, Veldink JH, Ophoff RA, Tripathi VB, Beleza A, Shah MN, Proitsi P, Van Hoecke A, Carmeliet P, Horvitz HR, Leigh PN, Shaw CE, van den Berg LH, Sham PC, Powell JF, Verstreken P, Brown RH Jr, Robberecht W, Al-Chalabi A., Free PMC Articles: PMC2638803, PMC2638803 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.
Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PW, Landers JE, Sapp P, Van Den Bosch L, Knight J, Neale BM, Turner MR, Veldink JH, Ophoff RA, Tripathi VB, Beleza A, Shah MN, Proitsi P, Van Hoecke A, Carmeliet P, Horvitz HR, Leigh PN, Shaw CE, van den Berg LH, Sham PC, Powell JF, Verstreken P, Brown RH Jr, Robberecht W, Al-Chalabi A, Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PW, Landers JE, Sapp P, Van Den Bosch L, Knight J, Neale BM, Turner MR, Veldink JH, Ophoff RA, Tripathi VB, Beleza A, Shah MN, Proitsi P, Van Hoecke A, Carmeliet P, Horvitz HR, Leigh PN, Shaw CE, van den Berg LH, Sham PC, Powell JF, Verstreken P, Brown RH Jr, Robberecht W, Al-Chalabi A., Free PMC Articles: PMC2638803, PMC2638803 | 11/19/2008 |
| We used hELP3 antisense oligonucl. to knock down hELP3 gene. The results showed that reduction of hELP3 mRNA and protein caused a suppression of HSP70-2 and histone H3 hypoacetylation. | hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells.
Han Q, Hou X, Su D, Pan L, Duan J, Cui L, Huang B, Lu J. | 01/21/2010 |