| Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. | Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease.
Lee RG, Balasubramaniam S, Stentenbach M, Kralj T, McCubbin T, Padman B, Smith J, Riley LG, Priyadarshi A, Peng L, Nuske MR, Webster R, Peacock K, Roberts P, Stark Z, Lemire G, Ito YA, Care4Rare Canada Consortium, Boycott KM, Geraghty MT, van Klinken JB, Ferdinandusse S, Zhou Y, Walsh R, Marcellin E, Thorburn DR, Rosciolli T, Fletcher J, Rackham O, Vaz FM, Reid GE, Filipovska A., Free PMC Article | 01/28/2023 |
| LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer. | LINC01272 Suppressed Cell Multiplication and Induced Apoptosis Via Regulating MiR-7-5p/CRLS1 Axis in Lung Cancer.
Ma X, Liu Y, Tian H, Zhang B, Wang M, Gao X., Free PMC Article | 11/13/2021 |
| Functionally, LINC00961 overexpression obviously inhibited cell proliferation, migration, and invasion in hepatocellular carcinoma cells. Mechanistically, LINC00961 regulated cardiolipin synthase 1 expression via sponging miR-5581-3p. | Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1.
Yin J, Liu Q, Chen C, Liu W. | 06/13/2020 |
| Knockdown of human CRLS1 leads to a cardiolipin decrease, phosphatidylglycerol accumulation and mitochondrial elongation. | Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology.
Matsumura A, Higuchi J, Watanabe Y, Kato M, Aoki K, Akabane S, Endo T, Oka T. | 12/22/2018 |
| transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment. | Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.
Kiebish MA, Yang K, Sims HF, Jenkins CM, Liu X, Mancuso DJ, Zhao Z, Guan S, Abendschein DR, Han X, Gross RW., Free PMC Article | 10/20/2012 |
| CLS mRNA levels cannot be correlated with CLS enzyme activity nor CL content in the LPS model of inflammation. | Cardiolipin synthase-1 mRNA expression does not correlate with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in mammalian lipopolysaccharide models of inflammation.
Lu B, Xu FY, Taylor WA, Feingold KR, Hatch GM. | 12/24/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| antibodies occur frequently in viral infections, particularly, in HIV but not in bacterial infections | Infections and the antiphospholipid syndrome.
García-Carrasco M, Galarza-Maldonado C, Mendoza-Pinto C, Escarcega RO, Cervera R. | 01/21/2010 |
| associated with Libman-Sacks endocarditis, cardiac manifestation of SLE | Revisiting Libman-Sacks endocarditis: a historical review and update.
Lee JL, Naguwa SM, Cheema GS, Gershwin ME. | 01/21/2010 |
| Patients with solid and non-solid malignancies display anticardiolipin antibodies associated with increased rate of thrombosis | Malignancies and catastrophic anti-phospholipid syndrome.
Miesbach W. | 01/21/2010 |
| anti-cardiolipin antibody positivity is an independent predictor of chronic renal failure | Renal involvement in the antiphospholipid syndrome (APS)-APS nephropathy.
Tektonidou MG. | 01/21/2010 |
| presence of cardiolipin autoantibodies is criteria for diagnostics of antiphospholipid syndrome | Clinical and laboratory features of the catastrophic antiphospholipid syndrome.
Stojanovich L, Marisavljevic D, Rovensky J, Djokovich A, Kozáková D, Milinic N. | 01/21/2010 |
| hCLS1 protein was localized to the mitochondria when transiently expressed in COS-7 cells | Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria.
Chen D, Zhang XY, Shi Y., Free PMC Article | 01/21/2010 |
| A human candidate gene/cDNA for cardiolipin synthase, C20orf155, was identified. | Identification and characterization of human cardiolipin synthase.
Houtkooper RH, Akbari H, van Lenthe H, Kulik W, Wanders RJ, Frentzen M, Vaz FM. | 01/21/2010 |
| We describe here a human gene for CLS and its analysis via RNAi knockdown on apoptotic progression. | Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis.
Choi SY, Gonzalvez F, Jenkins GM, Slomianny C, Chretien D, Arnoult D, Petit PX, Frohman MA. | 01/21/2010 |