| Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere damage repair. | Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere damage repair.
Estep KN, Tobias JW, Fernandez RJ, Beveridge BM, Johnson FB., Free PMC Article | 10/5/2024 |
| New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B. | New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B.
Kim H, Cho U, Hong SH, Park HS, Kim IH, An HJ, Shim BY, Kang JH., Free PMC Article | 08/30/2024 |
| EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells. | EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells.
García-Rodríguez N, Domínguez-García I, Domínguez-Pérez MDC, Huertas P., Free PMC Article | 06/24/2024 |
| SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner. | SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.
Geng A, Sun J, Tang H, Yu Y, Wang X, Zhang J, Wang X, Sun X, Zhou X, Gao N, Tan R, Xu Z, Jiang Y, Mao Z., Free PMC Article | 06/10/2024 |
| TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways. | TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Zhang Y, Wang ZZ, Han AQ, Yang MY, Zhu LX, Pan FM, Wang Y. | 03/11/2024 |
| ATR phosphorylates DHX9 at serine 321 to suppress R-loop accumulation upon genotoxic stress. | ATR phosphorylates DHX9 at serine 321 to suppress R-loop accumulation upon genotoxic stress.
Liu MY, Lin KR, Chien YL, Yang BZ, Tsui LY, Chu HC, Wu CP., Free PMC Article | 01/26/2024 |
| ADAR1 links R-loop homeostasis to ATR activation in replication stress response. | ADAR1 links R-loop homeostasis to ATR activation in replication stress response.
Zhang B, Li Y, Zhang J, Wang Y, Liang C, Lu T, Zhang C, Liu L, Qin Y, He J, Zhao X, Yu J, Hao J, Yang J, Li MJ, Yao Z, Ma S, Cheng H, Cheng T, Shi L., Free PMC Article | 11/30/2023 |
| Abrogation of ATR function preferentially augments cisplatin-induced cytotoxicity in PTEN-deficient breast cancer cells. | Abrogation of ATR function preferentially augments cisplatin-induced cytotoxicity in PTEN-deficient breast cancer cells.
Zhao JL, Yang J, Li K, Chen Y, Tang M, Zhu HL, Nie CL, Yuan Z, Zhao XY. | 11/1/2023 |
| Expression variations of DNA damage response genes ATM and ATR in blood cancer patients. | Expression variations of DNA damage response genes ATM and ATR in blood cancer patients.
Parvez A, Mahjabeen I, Mehmood A, Khan AU, Nisar A, Kayani MA. | 10/23/2023 |
| Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk. | Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.
Wilcox N, Dumont M, González-Neira A, Carvalho S, Joly Beauparlant C, Crotti M, Luccarini C, Soucy P, Dubois S, Nuñez-Torres R, Pita G, Gardner EJ, Dennis J, Alonso MR, Álvarez N, Baynes C, Collin-Deschesnes AC, Desjardins S, Becher H, Behrens S, Bolla MK, Castelao JE, Chang-Claude J, Cornelissen S, Dörk T, Engel C, Gago-Dominguez M, Guénel P, Hadjisavvas A, Hahnen E, Hartman M, Herráez B, SGBCC Investigators, Jung A, Keeman R, Kiechle M, Li J, Loizidou MA, Lush M, Michailidou K, Panayiotidis MI, Sim X, Teo SH, Tyrer JP, van der Kolk LE, Wahlström C, Wang Q, Perry JRB, Benitez J, Schmidt MK, Schmutzler RK, Pharoah PDP, Droit A, Dunning AM, Kvist A, Devilee P, Easton DF, Simard J., Free PMC Article | 10/19/2023 |
| Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1. | Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1.
Dwivedi D, Harry D, Meraldi P., Free PMC Article | 10/2/2023 |
| Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis. | Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis.
Jiang F, Huang X, Ling L, Tang S, Zhou H, Cai X, Wang Y., Free PMC Article | 09/30/2023 |
| A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells. | A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells.
Ahmed-Seghir S, Jalan M, Grimsley HE, Sharma A, Twayana S, Kosiyatrakul ST, Thompson C, Schildkraut CL, Powell SN., Free PMC Article | 09/6/2023 |
| Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase. | Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase.
Kang Y, Han YG, Khim KW, Choi WG, Ju MK, Park K, Shin KJ, Chae YC, Choi JH, Kim H, Lee JY., Free PMC Article | 08/30/2023 |
| ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms. | ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms.
Leung W, Simoneau A, Saxena S, Jackson J, Patel PS, Limbu M, Vindigni A, Zou L., Free PMC Article | 08/3/2023 |
| Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe. | Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe.
Patel JA, Zezelic C, Rageul J, Saldanha J, Khan A, Kim H., Free PMC Article | 07/24/2023 |
| The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression. | The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression.
Lu Y, Huang P, Li Y, Liu W, Li J, Zhao R, Feng H, Shi C, Cao G., Free PMC Article | 06/23/2023 |
| The "extreme phenotype approach" applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles. | The "extreme phenotype approach" applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles.
Chevarin M, Alcantara D, Albuisson J, Collonge-Rame MA, Populaire C, Selmani Z, Baurand A, Sawka C, Bertolone G, Callier P, Duffourd Y, Jonveaux P, Bignon YJ, Coupier I, Cornelis F, Cordier C, Mozelle-Nivoix M, Rivière JB, Kuentz P, Thauvin C, Boidot R, Ghiringhelli F, O'Driscoll M, Faivre L, Nambot S., Free PMC Article | 02/13/2023 |
| A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress. | A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress.
Egger T, Bordignon B, Coquelle A., Free PMC Article | 04/9/2022 |
| Shift in G1-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation. | Shift in G(1)-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation.
Li F, Mladenov E, Dueva R, Stuschke M, Timmermann B, Iliakis G., Free PMC Article | 03/12/2022 |
| Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer. | Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer.
Guo Y, Wang J, Benedict B, Yang C, van Gemert F, Ma X, Gao D, Wang H, Zhang S, Lieftink C, Beijersbergen RL, Te Riele H, Qiao X, Gao Q, Sun C, Qin W, Bernards R, Wang C., Free PMC Article | 02/26/2022 |
| Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination. | Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination.
Ishiai M., Free PMC Article | 02/19/2022 |
| Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM). | Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).
Tannous EA, Burgers PM., Free PMC Article | 01/22/2022 |
| Olaparib-induced Apoptosis Through EBNA1-ATR-p38 MAPK Signaling Pathway in Epstein-Barr Virus-positive Gastric Cancer Cells. | Olaparib-induced Apoptosis Through EBNA1-ATR-p38 MAPK Signaling Pathway in Epstein-Barr Virus-positive Gastric Cancer Cells.
Moon SH, Park NS, Noh MH, Kim YS, Cheong SH, Hur DY. | 01/15/2022 |
| microRNA27a-3p mediates reduction of the Wnt antagonist sFRP-1 in systemic sclerosis. | microRNA27a-3p mediates reduction of the Wnt antagonist sFRP-1 in systemic sclerosis.
Henderson J, Wilkinson S, Przyborski S, Stratton R, O'Reilly S., Free PMC Article | 01/15/2022 |