| Host 5'-3' Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication by Downregulating the dsRNA-Activated Kinase PKR. | Host 5'-3' Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication by Downregulating the dsRNA-Activated Kinase PKR.
BenDavid E, Pfaller CK, Pan Y, Samuel CE, Ma D., Free PMC Article | 12/3/2022 |
| Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence. | Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence.
Lekva T, Roland MCP, Estensen ME, Norwitz ER, Tilburgs T, Henriksen T, Bollerslev J, Normann KR, Magnus P, Olstad OK, Aukrust P, Ueland T., Free PMC Article | 01/1/2022 |
| Cellular 5'-3' mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication. | Cellular 5'-3' mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication.
Liu YC, Mok BW, Wang P, Kuo RL, Chen H, Shih SR., Free PMC Article | 12/25/2021 |
| Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identify disease-relevant transcripts containing G-rich motifs. | Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identify disease-relevant transcripts containing G-rich motifs.
Pashler AL, Towler BP, Jones CI, Haime HJ, Burgess T, Newbury SF., Free PMC Article | 10/2/2021 |
| We show that knockdown of human XRN1, CNOT6 and ETF1 genes in HepG2 cells led to significant alteration in stability of specific mRNAs, alterations in half-life were inversely associated with transcription rates, mostly not resulting in changes in abundance | mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells.
Singh P, James RS, Mee CJ, Morozov IY., Free PMC Article | 03/28/2020 |
| Another decapping activator PatL1 directly interacts with CIR and alleviates the CIR-mediated inhibition of CCR4-NOT activity in vitro. Ribosome profiling revealed that XRN1 loss impacts not only on mRNA levels but also on the translational efficiency of many cellular transcripts likely as a consequence of incomplete decay | A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decay.
Chang CT, Muthukumar S, Weber R, Levdansky Y, Chen Y, Bhandari D, Igreja C, Wohlbold L, Valkov E, Izaurralde E., Free PMC Article | 12/14/2019 |
| This work provides insight into the role of the RNA decay factor Xrn1/XRN1 as a post-transcriptional regulator of autophagy. | The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy.
Delorme-Axford E, Abernathy E, Lennemann NJ, Bernard A, Ariosa A, Coyne CB, Kirkegaard K, Klionsky DJ., Free PMC Article | 10/5/2019 |
| Authors use a series of assays to demonstrate that the 3'-terminal portion of the nucleocapsid (N) mRNA of Rift Valley fever virus can effectively stall and repress XRN1. The region responsible for impeding XRN1 includes a G-rich portion that likely forms a G-quadruplex structure. The 3'-terminal portions of ambisense-derived transcripts of multiple arenaviruses also stalled XRN1. | Identification of phlebovirus and arenavirus RNA sequences that stall and repress the exoribonuclease XRN1.
Charley PA, Wilusz CJ, Wilusz J., Free PMC Article | 12/1/2018 |
| Insertion of 5'-3' exoribonuclease 1 (XRN1)-resistant sequences (xrRNAs) into different reporter mRNAs allowed to monitor RNA decay activity by the nonsense-mediated mRNA decay pathway (NMD). | Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences.
Boehm V, Gerbracht JV, Marx MC, Gehring NH., Free PMC Article | 09/29/2018 |
| These findings suggest that sequestration of the exoribonucleases DIS3L2 and XRN1 to nuclear inclusions may be related to the pathogenesis of intranuclear inclusion body disease | Immunohistochemical localization of exoribonucleases (DIS3L2 and XRN1) in intranuclear inclusion body disease.
Mori F, Tanji K, Miki Y, Toyoshima Y, Sasaki H, Yoshida M, Kakita A, Takahashi H, Wakabayashi K. | 07/28/2018 |
| Data show that the AR-miR-204-XRN1-miR-34a positive feedback loop and a dual function of miR-204/XRN1 axis in prostate cancer. | A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells.
Ding M, Lin B, Li T, Liu Y, Li Y, Zhou X, Miao M, Gu J, Pan H, Yang F, Li T, Liu XY, Li R., Free PMC Article | 05/28/2016 |
| Thus, Xrn1 is a cellular factor regulating dsRNA accumulation and dsRNA-responsive innate immune effectors. | Cellular 5'-3' mRNA exonuclease Xrn1 controls double-stranded RNA accumulation and anti-viral responses.
Burgess HM, Mohr I., Free PMC Article | 01/2/2016 |
| Occupation of each miR-122 binding site on 5' untranslated region of the hepatitis C virus genome contributes equally and cooperatively to virus replication via protecting from Xrn1 exoribonuclease degradation. | Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5' Untranslated Region.
Thibault PA, Huys A, Amador-Cañizares Y, Gailius JE, Pinel DE, Wilson JA., Free PMC Article | 08/1/2015 |
| Authors conclude that Xrn1 is the dominant 5' exoribonuclease mediating decay of hepatitis C virus RNA and that miR-122 provides protection against it | Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.
Li Y, Yamane D, Lemon SM., Free PMC Article | 06/20/2015 |
| Mouse Xrn1 plays a role in RNA turnover. | A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates.
Bashkirov VI, Scherthan H, Solinger JA, Buerstedde JM, Heyer WD., Free PMC Article | 09/19/2013 |
| Data show that 5' exonuclease Xrn1 knockdown and miR-122 supplementation have equal, redundant, and nonadditive effects on the rate of viral RNA decay, indicating that miR-122 protects HCV RNA from 5' decay. | Competing and noncompeting activities of miR-122 and the 5' exonuclease Xrn1 in regulation of hepatitis C virus replication.
Li Y, Masaki T, Yamane D, McGivern DR, Lemon SM., Free PMC Article | 05/4/2013 |
| findings reveal a role for XRN1 in decapping and provide a molecular basis for the coupling of decapping to 5'-->3' mRNA degrada | A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.
Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E. | 02/9/2013 |
| LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in cytoplasmic foci | The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T., Free PMC Article | 01/21/2010 |