| The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis. | The accurate bypass of pyrimidine dimers by DNA polymerase eta contributes to ultraviolet-induced mutagenesis.
Menck CFM, Galhardo RS, Quinet A. | 07/26/2024 |
| The peroxidation-derived DNA adduct, 6-oxo-M1dG, is a strong block to replication by human DNA polymerase eta. | The peroxidation-derived DNA adduct, 6-oxo-M(1)dG, is a strong block to replication by human DNA polymerase η.
Richie-Jannetta R, Pallan P, Kingsley PJ, Kamdar N, Egli M, Marnett LJ., Free PMC Article | 09/18/2023 |
| Mutagenic incorporation of inosine into DNA via T:I mismatch formation by human DNA polymerase eta (poleta). | Mutagenic incorporation of inosine into DNA via T:I mismatch formation by human DNA polymerase eta (polη).
Averill JR, Jung H. | 05/17/2023 |
| Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase eta and reduces DNA synthesis fidelity. | Primer terminal ribonucleotide alters the active site dynamics of DNA polymerase η and reduces DNA synthesis fidelity.
Chang C, Lee Luo C, Eleraky S, Lin A, Zhou G, Gao Y., Free PMC Article | 04/4/2023 |
| Human DNA polymerase eta promotes RNA-templated error-free repair of DNA double-strand breaks. | Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks.
Chakraborty A, Tapryal N, Islam A, Sarker AH, Manohar K, Mitra J, Hegde ML, Hazra T., Free PMC Article | 03/30/2023 |
| Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations. | Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations.
Feltes BC, Menck CFM. | 12/17/2022 |
| Identification of Frameshift Variants in POLH Gene Causing Xeroderma Pigmentosum in Two Consanguineous Pakistani Families. | Identification of Frameshift Variants in POLH Gene Causing Xeroderma Pigmentosum in Two Consanguineous Pakistani Families.
Zamani GY, Khan R, Karim N, Ahmed ZM, Naeem M., Free PMC Article | 04/23/2022 |
| Manganese Is a Strong Specific Activator of the RNA Synthetic Activity of Human Poleta. | Manganese Is a Strong Specific Activator of the RNA Synthetic Activity of Human Polη.
Balint E, Unk I., Free PMC Article | 01/29/2022 |
| Incorporation of 5',8-cyclo-2'deoxyadenosines by DNA repair polymerases via base excision repair. | Incorporation of 5',8-cyclo-2'deoxyadenosines by DNA repair polymerases via base excision repair.
Tsegay PS, Hernandez D, Brache C, Chatgilialoglu C, Krokidis MG, Chapagain P, Liu Y., Free PMC Article | 01/29/2022 |
| Genetic and physical interactions between Poleta and Rev1 in response to UV-induced DNA damage in mammalian cells. | Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells.
Bi T, Niu X, Qin C, Xiao W., Free PMC Article | 01/29/2022 |
| Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites. | Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites.
Twayana S, Bacolla A, Barreto-Galvez A, De-Paula RB, Drosopoulos WC, Kosiyatrakul ST, Bouhassira EE, Tainer JA, Madireddy A, Schildkraut CL., Free PMC Article | 01/15/2022 |
| Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells. | Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells.
Powell BV, Bacurio JHT, Basu AK., Free PMC Article | 04/3/2021 |
| AID Overlapping and Poleta Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes. | AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes.
Tang C, Bagnara D, Chiorazzi N, Scharff MD, MacCarthy T., Free PMC Article | 03/27/2021 |
| Multisite SUMOylation restrains DNA polymerase eta interactions with DNA damage sites. | Multisite SUMOylation restrains DNA polymerase η interactions with DNA damage sites.
Guérillon C, Smedegaard S, Hendriks IA, Nielsen ML, Mailand N., Free PMC Article | 01/9/2021 |
| Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation. | Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation.
Federico MB, Siri SO, Calzetta NL, Paviolo NS, de la Vega MB, Martino J, Campana MC, Wiesmüller L, Gottifredi V. | 11/28/2020 |
| Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase eta. | Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η.
Sassa A, Tada H, Takeishi A, Harada K, Suzuki M, Tsuda M, Sasanuma H, Takeda S, Sugasawa K, Yasui M, Honma M, Ura K., Free PMC Article | 10/31/2020 |
| Data suggest that PolH expression is controlled by APA and that the short PolH transcript produced by APA can escape miR-619-mediated repression and, subsequently, confers PolH-mediated cisplatin resistance. | A PolH Transcript with a Short 3'UTR Enhances PolH Expression and Mediates Cisplatin Resistance.
Zhang J, Sun W, Ren C, Kong X, Yan W, Chen X., Free PMC Article | 04/11/2020 |
| poleta readily accommodated the N7-methyl-2-deoxyguanosine:dCTP base pair with little conformational change of protein and DNA. | Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η.
Koag MC, Jung H, Kou Y, Lee S., Free PMC Article | 04/11/2020 |
| This study used a linear free energy relationship analysis, in the form of a Bronsted plot of log( kpol) versus p Ka4, for Y-family error-prone DNA polymerase eta and X-family DNA polymerases gamma and beta to determine the extent to which different electrostatic active site environments alter kpol values. The apparent chemical rate constant ( kpol) is the rate-determining step for the three pols. | A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β.
Oertell K, Florián J, Haratipour P, Crans DC, Kashemirov BA, Wilson SH, McKenna CE, Goodman MF., Free PMC Article | 01/18/2020 |
| Epigenetically modified N(6)-methyladenine inhibits DNA replication by human DNA polymerase eta | Epigenetically modified N(6)-methyladenine inhibits DNA replication by human DNA polymerase η.
Du K, Zhang X, Zou Z, Li B, Gu S, Zhang S, Qu X, Ling Y, Zhang H. | 01/11/2020 |
| Diverse roles of RAD18 and Y-family DNA polymerases, such as DNA polymerase eta, in tumorigenesis has been described. (Review) | Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis.
Yang Y, Gao Y, Zlatanou A, Tateishi S, Yurchenko V, Rogozin IB, Vaziri C., Free PMC Article | 12/7/2019 |
| A substantial excess of single and tandem somatic mutations within known pol eta mutable motifs was noted in skin cancer as well as in many other types of human cancer. | DNA polymerase η mutational signatures are found in a variety of different types of cancer.
Rogozin IB, Goncearenco A, Lada AG, De S, Yurchenko V, Nudelman G, Panchenko AR, Cooper DN, Pavlov YI., Free PMC Article | 09/7/2019 |
| In addition to the two Mg(2+) ions aligning the active site of DNA polymerase eta, experiments suggest that a third Mg(2+) ion could play an essential catalytic role. The simulations with three metal ions in the active site suggest that the third metal ion may play a catalytic role through electrostatic interactions with the leaving group. | Exploring the Role of the Third Active Site Metal Ion in DNA Polymerase η with QM/MM Free Energy Simulations.
Stevens DR, Hammes-Schiffer S., Free PMC Article | 06/29/2019 |
| Findings demonstrate a novel role of Poleta O-GlcNAcylation in translesion DNA synthesis regulation and genome stability maintenance. | Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis.
Ma X, Liu H, Li J, Wang Y, Ding YH, Shen H, Yang Y, Sun C, Huang M, Tu Y, Liu Y, Zhao Y, Dong MQ, Xu P, Tang TS, Guo C., Free PMC Article | 10/6/2018 |
| Rad18, independently of its ubiquitin ligase activity, promotes DNA polymerase eta SUMOylation by facilitating its interaction with its SUMO ligase PIAS1 and is required for DNA polymerase eta function at difficult to replicate loci. | Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA.
Despras E, Sittewelle M, Pouvelle C, Delrieu N, Cordonnier AM, Kannouche PL., Free PMC Article | 09/8/2018 |