| Identification of a Novel miR-195-5p/PNN Axis in Colorectal Cancer. | Identification of a Novel miR-195-5p/PNN Axis in Colorectal Cancer.
Piccinno E, Scalavino V, Labarile N, De Marinis L, Armentano R, Giannelli G, Serino G., Free PMC Article | 07/5/2024 |
| Methyltransferase like 3 enhances pinin mRNA stability through N(6) -methyladenosine modification to augment tumourigenesis of colon adenocarcinoma. | Methyltransferase like 3 enhances pinin mRNA stability through N(6) -methyladenosine modification to augment tumourigenesis of colon adenocarcinoma.
He M, Jiang D, Xun A, Yang J, Luo Q, Wu H. | 11/5/2022 |
| The prognostic effect of PNN in digestive tract cancers and its correlation with the tumor immune landscape in colon adenocarcinoma. | The prognostic effect of PNN in digestive tract cancers and its correlation with the tumor immune landscape in colon adenocarcinoma.
Zhang H, Jin M, Ye M, Bei Y, Yang S, Liu K., Free PMC Article | 04/23/2022 |
| Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR3303p/PNN axis. | Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR‑330‑3p/PNN axis.
Qin G, Wu X., Free PMC Article | 11/6/2021 |
| Pinin acts as a poor prognostic indicator for renal cell carcinoma by reducing apoptosis and promoting cell migration and invasion. | Pinin acts as a poor prognostic indicator for renal cell carcinoma by reducing apoptosis and promoting cell migration and invasion.
Jin M, Li D, Liu W, Wang P, Xiang Z, Liu K., Free PMC Article | 09/25/2021 |
| It has been shown that in the absence of piRNAs, human PIWIL1 in pancreatic ductal adenocarcinoma (PDAC) functions as an oncoprotein by activating the anaphase promoting complex/cyclosome (APC/C) E3 complex, which then targets a critical cell adhesion-related protein, Pinin, to enhance PDAC metastasis. | piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis.
Li F, Yuan P, Rao M, Jin CH, Tang W, Rong YF, Hu YP, Zhang F, Wei T, Yin Q, Liang T, Wu L, Li J, Li D, Liu Y, Lou W, Zhao S, Liu MF. | 04/25/2020 |
| By a transcriptomic approach and validates PNN and KCNQ1OT1 as molecular biomarkers. | RNA sequencing reveals PNN and KCNQ1OT1 as predictive biomarkers of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy.
Mini E, Lapucci A, Perrone G, D'Aurizio R, Napoli C, Brugia M, Landini I, Tassi R, Picariello L, Simi L, Mancini I, Messerini L, Magi A, Pinzani P, Mazzei T, Tonelli F, Nobili S. | 01/25/2020 |
| Data suggest that SNRPA1, SNRPD1, and PNN are key players in the regulation of pluripotency-specific spliceosome assembly and the acquisition and maintenance of pluripotency. | The unique spliceosome signature of human pluripotent stem cells is mediated by SNRPA1, SNRPD1, and PNN.
Kim YD, Lee J, Kim HS, Lee MO, Son MY, Yoo CH, Choi JK, Lee SC, Cho YS. | 06/16/2018 |
| Pinin contributes to hepatocellular carcinoma progression and resistance to glucose deprivation-induced apoptosis via maintaining ERK1/2 activation | Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis.
Yang X, Sun D, Dong C, Tian Y, Gao Z, Wang L., Free PMC Article | 01/13/2018 |
| Our findings suggested that PNN, as a valuable marker of prognosis, has important influence on the progression of colorectal cancer | Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway.
Wei Z, Ma W, Qi X, Zhu X, Wang Y, Xu Z, Luo J, Wang D, Guo W, Li X, Xin S, Yu J, Li G., Free PMC Article | 12/23/2017 |
| Pinin and CtBP are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells. | Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells.
Zhang Y, Kwok JS, Choi PW, Liu M, Yang J, Singh M, Ng SK, Welch WR, Muto MG, Tsui SK, Sugrue SP, Berkowitz RS, Ng SW., Free PMC Article | 12/2/2017 |
| These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce. | RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells.
Akin D, Newman JR, McIntyre LM, Sugrue SP., Free PMC Article | 10/22/2016 |
| PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium. | Role of Pnn in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.
Joo JH, Ryu D, Peng Q, Sugrue SP., Free PMC Article | 06/27/2015 |
| ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics. | Transcriptomic analysis of PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells.
Joo JH, Correia GP, Li JL, Lopez MC, Baker HV, Sugrue SP., Free PMC Article | 03/23/2013 |
| Urinary desmosine level is an important biologoical marker, in patients treated with bilateral knee replacement and hydrocortison therapy. | Steroid modulation of cytokine release and desmosine levels in bilateral total knee replacement: a prospective, double-blind, randomized controlled trial.
Jules- Elysee KM, Wilfred SE, Memtsoudis SG, Kim DH, YaDeau JT, Urban MK, Lichardi ML, McLawhorn AS, Sculco TP. | 02/9/2013 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Corepressor CtBP and PNN/DRS differentially modulate transcription and splicing of the E-cadherin gene. | Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.
Alpatov R, Shi Y, Munguba GC, Moghimi B, Joo JH, Bungert J, Sugrue SP., Free PMC Article | 01/21/2010 |
| Pnn may participate, via its interaction with RNPS1, in mRNA metabolism in the nucleus, including mRNA splicing and export | Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1.
Li C, Lin RI, Lai MC, Ouyang P, Tarn WY., Free PMC Article | 01/21/2010 |
| Pnn may play a general role in the control of the cellular amount of family SR proteins through down-regulation of its own expression | Loss of Pnn expression attenuates expression levels of SR family splicing factors and modulates alternative pre-mRNA splicing in vivo.
Chiu Y, Ouyang P. | 01/21/2010 |
| the interaction of Pnn with the corepressor CtBP1 may modulate repression of E-cadherin transcription by CtBP1 | Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene.
Alpatov R, Munguba GC, Caton P, Joo JH, Shi Y, Shi Y, Hunt ME, Sugrue SP., Free PMC Article | 01/21/2010 |
| Pinin functions as a splicing regulator which participates itself directly in splicing reaction or indirectly via other components of splicing machinery | Modulation of alternative pre-mRNA splicing in vivo by pinin.
Wang P, Lou PJ, Leu S, Ouyang P. | 01/21/2010 |