| Cardiomyocyte-specific overexpression of FPN1 diminishes cardiac hypertrophy induced by chronic intermittent hypoxia. | Cardiomyocyte-specific overexpression of FPN1 diminishes cardiac hypertrophy induced by chronic intermittent hypoxia.
Song JX, Xu S, Chen Q, Gou Y, Zhao CB, Jia CL, Liu H, Zhang Z, Li BL, Gao Y, Zhao Y, Ji ES., Free PMC Article | 08/29/2024 |
| Elevated SLC40A1 impairs cardiac function and exacerbates mitochondrial dysfunction, oxidative stress, and apoptosis in ischemic myocardia. | Elevated SLC40A1 impairs cardiac function and exacerbates mitochondrial dysfunction, oxidative stress, and apoptosis in ischemic myocardia.
Feng R, Wang D, Li T, Liu X, Peng T, Liu M, Ren G, Xu H, Luo H, Lu D, Qi B, Zhang M, Li Y., Free PMC Article | 01/9/2024 |
| Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation. | Role of hepcidin upregulation and proteolytic cleavage of ferroportin 1 in hepatitis C virus-induced iron accumulation.
Ohta K, Ito M, Chida T, Nakashima K, Sakai S, Kanegae Y, Kawasaki H, Aoshima T, Takabayashi S, Takahashi H, Kawata K, Shoji I, Sawasaki T, Suda T, Suzuki T., Free PMC Article | 08/31/2023 |
| Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke. | Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke.
Zheng H, Guo X, Kang S, Li Z, Tian T, Li J, Wang F, Yu P, Chang S, Chang YZ., Free PMC Article | 02/28/2023 |
| Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells. | Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells.
You L, Yu PP, Dong T, Guo W, Chang S, Zheng B, Ci Y, Wang F, Yu P, Gao G, Chang YZ., Free PMC Article | 08/6/2022 |
| Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin-ferroportin axis. | Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin-ferroportin axis.
Deng Q, Yang S, Sun L, Dong K, Li Y, Wu S, Huang R., Free PMC Article | 01/22/2022 |
| RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation. | RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.
Jiang L, Wang J, Wang K, Wang H, Wu Q, Yang C, Yu Y, Ni P, Zhong Y, Song Z, Xie E, Hu R, Min J, Wang F., Free PMC Article | 12/4/2021 |
| Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1alpha/MAPK Pathway in the Liver. | Fasting Increases Iron Export by Modulating Ferroportin 1 Expression Through the Ghrelin/GHSR1α/MAPK Pathway in the Liver.
Luo Q, Hu J, Yang G, Yuan X, Chen Z, Wang D, Lu Y, Zhu L, Wang G. | 07/31/2021 |
| Marginally reduced maternal hepatic and splenic ferroportin under severe nutritional iron deficiency in pregnancy maintains systemic iron supply. | Marginally reduced maternal hepatic and splenic ferroportin under severe nutritional iron deficiency in pregnancy maintains systemic iron supply.
Mazgaj R, Lipiński P, Edison ES, Bednarz A, Staroń R, Haberkiewicz O, Lenartowicz M, Smuda E, Jończy A, Starzyński RR., Free PMC Article | 06/26/2021 |
| Brain iron deficiency and affected contextual fear memory in mice with conditional Ferroportin1 ablation in the brain. | Brain iron deficiency and affected contextual fear memory in mice with conditional Ferroportin1 ablation in the brain.
Wu Q, Hao Q, Li H, Wang B, Wang P, Jin X, Yu P, Gao G, Chang YZ. | 06/26/2021 |
| Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds. | Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds.
Gong L, Tian X, Zhou J, Dong Q, Tan Y, Lu Y, Wu J, Zhao Y, Liu X., Free PMC Article | 08/22/2020 |
| Local hepcidin increased intracellular iron overload via the degradation of ferroportin in the kidney. | Local hepcidin increased intracellular iron overload via the degradation of ferroportin in the kidney.
Pan S, Qian ZM, Cui S, Zhao D, Lan W, Wang X, Chen X. | 08/15/2020 |
| This study concluded that even when the ferroportin expression is high, ceruloplasmin remains a limiting factor in the release of iron to the extracellular environment. | Functional iron deficiency in toxic milk mutant mice (tx-J) despite high hepatic ferroportin: a critical role of decreased GPI-ceruloplasmin expression in liver macrophages.
Jończy A, Lipiński P, Ogórek M, Starzyński RR, Krzysztofik D, Bednarz A, Krzeptowski W, Szudzik M, Haberkiewicz O, Miłoń A, Grzmil P, Lenartowicz M. | 06/6/2020 |
| results thus reveal that B. fragilis can influence macrophage iron handling and inflammatory responses by modulating ferroportin expression. | The commensal bacterium Bacteroides fragilis down-regulates ferroportin expression and alters iron homeostasis in macrophages.
Verma S, Prescott R, Cherayil BJ., Free PMC Article | 05/30/2020 |
| the relative distributions of manganese and iron in TMPRSS6 deficient mice, which are characterized by constitutively high expression of the iron regulatory hormone hepcidin and, consequently, very low FPN levels in their tissues, were examined. | Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis.
Jin L, Frazer DM, Lu Y, Wilkins SJ, Ayton S, Bush A, Anderson GJ. | 05/16/2020 |
| findings reveal that iron/ferroportin plays a largely underestimated role in macrophage trophic function in skin homeostasis and repair. | Macrophage ferroportin is essential for stromal cell proliferation in wound healing.
Recalcati S, Gammella E, Buratti P, Doni A, Anselmo A, Locati M, Cairo G., Free PMC Article | 05/2/2020 |
| Erythroblast-specific Ferroportin (FPN), knockout (Fpn KO) mice developed lower serum iron levels in conjunction with tissue iron overload and increased FPN expression in spleen and liver without changing hepcidin levels. | Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress.
Zhang DL, Ghosh MC, Ollivierre H, Li Y, Rouault TA., Free PMC Article | 08/3/2019 |
| We will finally summarize data on the role of the iron binding protein lactoferrin on the regulation of the ferroportin/ceruloplasmin couple and of other proteins involved in iron homeostasis in inflamed human macrophages | The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin.
Bonaccorsi di Patti MC, Cutone A, Polticelli F, Rosa L, Lepanto MS, Valenti P, Musci G. | 06/1/2019 |
| Increased intracellular growth due to compromised expressions of Fpn and FBXL5 by specific siRNAs reveals that Leishmania donovani uses a novel strategy of manipulating IRP2-FBXL5 axis to inhibit host Fpn expression. | Leishmania donovani inhibits ferroportin translation by modulating FBXL5-IRP2 axis for its growth within host macrophages.
Das NK, Sandhya S, G VV, Kumar R, Singh AK, Bal SK, Kumari S, Mukhopadhyay CK. | 05/4/2019 |
| Expression of solute carrier family 9 (sodium/hydrogen exchanger) member 2 (Slc9a2) within the mammary gland can mediate the effect of milk mineral concentration quantitative trait loci 9 (Mmcq9) on milk iron concentration. | In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1.
Hadsell DL, Hadsell LA, Rijnkels M, Carcamo-Bahena Y, Wei J, Williamson P, Grusak MA. | 02/2/2019 |
| The Slc40a1 deletion mildly increased iron levels in both precursor and mature osteoclasts, and its loss in precursors, but not in mature cells, increased osteoclastogenesis and decreased bone mass in vivo Of note, these phenotypes were more pronounced in female than in male mice. | Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo.
Wang L, Fang B, Fujiwara T, Krager K, Gorantla A, Li C, Feng JQ, Jennings ML, Zhou J, Aykin-Burns N, Zhao H., Free PMC Article | 01/26/2019 |
| study indicates that copper is an important player in the regulation of the Slc40a1 gene expression. | Copper therapy reduces intravascular hemolysis and derepresses ferroportin in mice with mosaic mutation (Atp7a(mo-ms)): An implication for copper-mediated regulation of the Slc40a1 gene expression.
Lenartowicz M, Starzyński RR, Jończy A, Staroń R, Antoniuk J, Krzeptowski W, Grzmil P, Bednarz A, Pierzchała O, Ogórek M, Rajfur Z, Baster Z, Lipiński P. | 12/1/2018 |
| Pulmonary iron overload is associated with oxidative stress, restrictive lung disease with decreased total lung capacity and reduced blood oxygen saturation in homozygous Slc40a1(C326S/C326S) mice compared to wild-type controls. | Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.
Neves J, Leitz D, Kraut S, Brandenberger C, Agrawal R, Weissmann N, Mühlfeld C, Mall MA, Altamura S, Muckenthaler MU., Free PMC Article | 03/31/2018 |
| ferroportin mRNA downregulation depends on M2 subtype polarization of macrophage | Inflammation-induced up-regulation of hepcidin and down-regulation of ferroportin transcription are dependent on macrophage polarization.
Agoro R, Mura C. | 01/13/2018 |
| Fasting upregulates Fpn1 expression in spleen and peritoneal macrophages, probably via a ghrelin/GHSR1a/MAPK signaling pathway. | Fasting up-regulates ferroportin 1 expression via a Ghrelin/GHSR/MAPK signaling pathway.
Luo QQ, Zhou YF, Chen MY, Liu L, Ma J, Zhang MW, Zhang FL, Ke Y, Qian ZM. | 10/14/2017 |