| Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor microenvironment and predict overall survival of lung adenocarcinoma patients. | Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor microenvironment and predict overall survival of lung adenocarcinoma patients.
Wei C, Li L, Qiao Y, Chen Y, Zhang C, Xie J, Fang J, Liang Z, Huang D, Wu D., Free PMC Article | 09/17/2024 |
| NADPH Alters DUOX1 Calcium Responsiveness. | NADPH Alters DUOX1 Calcium Responsiveness.
Conner GE., Free PMC Article | 08/30/2024 |
| Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure. | Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure.
Li YS, Xia J, Chen CY, Ren SH, He MR., Free PMC Article | 08/9/2024 |
| ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal squamous cell carcinoma cells through m6A-dependent modification. | ZC3H13 reduced DUOX1-mediated ferroptosis in laryngeal squamous cell carcinoma cells through m6A-dependent modification.
Huang L, Chen G, He J, Wang P. | 09/8/2023 |
| DUOX1 Gene Missense Mutation Confers Susceptibility on Type 2 Amiodarone-Induced Thyrotoxicosis. | DUOX1 Gene Missense Mutation Confers Susceptibility on Type 2 Amiodarone-Induced Thyrotoxicosis.
Biakina O, Mitina Y, Gognieva D, Axenova M, Ermolaeva A, Bestavashvili A, Fadeev V, Syrkin A, Kopylov P., Free PMC Article | 03/27/2023 |
| Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation. | Diet-induced obesity worsens allergen-induced type 2/type 17 inflammation in airways by enhancing DUOX1 activation.
Habibovic A, Hristova M, Morris CR, Lin MJ, Cruz LC, Ather JL, Geiszt M, Anathy V, Janssen-Heininger YMW, Poynter ME, Dixon AE, van der Vliet A., Free PMC Article | 02/27/2023 |
| Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca(2+) signaling during T cell activation. | Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca(2+) signaling during T cell activation.
Gu F, Krüger A, Roggenkamp HG, Alpers R, Lodygin D, Jaquet V, Möckl F, Hernandez C LC, Winterberg K, Bauche A, Rosche A, Grasberger H, Kao JY, Schetelig D, Werner R, Schröder K, Carty M, Bowie AG, Huber S, Meier C, Mittrücker HW, Heeren J, Krause KH, Flügel A, Diercks BP, Guse AH. | 01/29/2022 |
| Knockdown of dual oxidase 1 suppresses activin A-induced fibrosis in cardiomyocytes via the reactive oxygen species-dependent pyroptotic pathway. | Knockdown of dual oxidase 1 suppresses activin A-induced fibrosis in cardiomyocytes via the reactive oxygen species-dependent pyroptotic pathway.
Li S, Li Z, Yin R, Nie J, Fu Y, Ying R. | 09/4/2021 |
| NADPH oxidase DUOX1 sustains TGF-beta1 signalling and promotes lung fibrosis. | NADPH oxidase DUOX1 sustains TGF-β1 signalling and promotes lung fibrosis.
Louzada RA, Corre R, Ameziane El Hassani R, Meziani L, Jaillet M, Cazes A, Crestani B, Deutsch E, Dupuy C. | 07/24/2021 |
| Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease. | Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease.
Schiffers C, van de Wetering C, Bauer RA, Habibovic A, Hristova M, Dustin CM, Lambrichts S, Vacek PM, Wouters EF, Reynaert NL, van der Vliet A., Free PMC Article | 06/5/2021 |
| Knockdown of Dual Oxidase 1 (DUOX1) Promotes Wound Healing by Regulating Reactive Oxygen Species (ROS) by Activation of Nuclear Kactor kappa B (NF-kappaB) Signaling. | Knockdown of Dual Oxidase 1 (DUOX1) Promotes Wound Healing by Regulating Reactive Oxygen Species (ROS) by Activation of Nuclear Kactor kappa B (NF-κB) Signaling.
Wang H, Lu H, Wu Y., Free PMC Article | 02/20/2021 |
| Structures of human dual oxidase 1 complex in low-calcium and high-calcium states. | Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.
Wu JX, Liu R, Song K, Chen L., Free PMC Article | 01/30/2021 |
| DUOX1 and NOX2 expression are associated with mucosal immunity activated in cervical squamous cell carcinoma and predicts a favorable prognosis in cervical cancer patients. | Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response.
Cho SY, Kim S, Son MJ, Kim G, Singh P, Kim HN, Choi HG, Yoo HJ, Ko YB, Lee BS, Eun HS., Free PMC Article | 04/18/2020 |
| analysis of mutations in the DUOX2 and DUOX1 genes in two Sudanese families with dyshormonogenic congenital hypothyroidism | Congenital Hypothyroidism due to Oligogenic Mutations in Two Sudanese Families.
Watanabe Y, Bruellman RJ, Ebrhim RS, Abdullah MA, Dumitrescu AM, Refetoff S, Weiss RE., Free PMC Article | 02/15/2020 |
| this review discusses the current level of understanding with respect to the biological role(s) of DUOX enzymes and the unique role of DUOX1 in mediating innate immune responses to epithelial injury and allergens and in the development of allergic disease. | Dual oxidase: a novel therapeutic target in allergic disease.
van der Vliet A, Danyal K, Heppner DE., Free PMC Article | 08/10/2019 |
| Authors demonstrate here that DUOX1 is silenced in breast cancer, which seems to be involved in breast carcinogenesis. | DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress.
Fortunato RS, Gomes LR, Munford V, Pessoa CF, Quinet A, Hecht F, Kajitani GS, Milito CB, Carvalho DP, Menck CFM., Free PMC Article | 10/20/2018 |
| Silencing DUOX1 by siRNA attenuated IL-13-mediated increases in superoxide, but did not reduce autophagy activities. | Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation.
Dickinson JD, Sweeter JM, Warren KJ, Ahmad IM, De Deken X, Zimmerman MC, Brody SL., Free PMC Article | 07/14/2018 |
| We analyzed the expression of NADPH oxidase isoforms and found both A431 and HaCaT cells to express the calcium-sensitive NADPH oxidase, Dual oxidase 1 (Duox1) and its protein partner Duox activator 1 (DuoxA1).Our observations provide evidence for a new signaling paradigm in which changes of intracellular calcium concentration are transformed into redox signals through the calcium-dependent activation of Duox1. | Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1.
Sirokmány G, Pató A, Zana M, Donkó Á, Bíró A, Nagy P, Geiszt M. | 01/13/2018 |
| DUOX1 missense mutation plays a role in congenital hypothyroidism. | Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.
Aycan Z, Cangul H, Muzza M, Bas VN, Fugazzola L, Chatterjee VK, Persani L, Schoenmakers N., Free PMC Article | 10/7/2017 |
| Our findings implicate epithelial DUOX1 as a pivotal mediator of IL-33-dependent activation of innate airway type 2 immune responses to common airborne allergens and indicate that enhanced DUOX1 expression and IL-33 secretion might present important contributing features of allergic asthma. | Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses.
Hristova M, Habibovic A, Veith C, Janssen-Heininger YM, Dixon AE, Geiszt M, van der Vliet A., Free PMC Article | 06/24/2017 |
| Cox multivariate regression analysis demonstrated that DUOX1, GLS2, FBP1 and age were independent risk factors for the prognosis of HCC patients after surgery | The combination of three molecular markers can be a valuable predictive tool for the prognosis of hepatocellular carcinoma patients.
Chen SS, Yu KK, Ling QX, Huang C, Li N, Zheng JM, Bao SX, Cheng Q, Zhu MQ, Chen MQ., Free PMC Article | 04/22/2017 |
| DUOX1 expression in liver tumors is a potential prognostic tool for patients. | Dual oxidase 1: A predictive tool for the prognosis of hepatocellular carcinoma patients.
Chen S, Ling Q, Yu K, Huang C, Li N, Zheng J, Bao S, Cheng Q, Zhu M, Chen M., Free PMC Article | 03/18/2017 |
| Nox4 and Duox1/Duox2 mediate redox activation of mesenchymal cell migration by PDGF. | Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.
Tyurin-Kuzmin PA, Zhdanovskaya ND, Sukhova AA, Sagaradze GD, Albert EA, Ageeva LV, Sharonov GV, Vorotnikov AV, Tkachuk VA., Free PMC Article | 03/18/2017 |
| These data reveal a key role of DUOX1-dependent hydrogen peroxide production in long-term persistent radio-induced DNA damage. | NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation.
Ameziane-El-Hassani R, Talbot M, de Souza Dos Santos MC, Al Ghuzlan A, Hartl D, Bidart JM, De Deken X, Miot F, Diallo I, de Vathaire F, Schlumberger M, Dupuy C., Free PMC Article | 07/4/2015 |
| Studies demonstrate the importance of DUOX1 in epithelial redox signaling through reversible S-glutathionylation of a range of proteins, including proteins involved in cytoskeletal regulation and MAPK signaling pathways involved in cell migration. | Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells.
Hristova M, Veith C, Habibovic A, Lam YW, Deng B, Geiszt M, Janssen-Heininger YM, van der Vliet A., Free PMC Article | 06/20/2015 |