| PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells. | PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells.
Liu L, Feng X, Fan C, Kong D, Feng X, Sun C, Xu Y, Li B, Jiang Y, Zheng C. | 09/4/2024 |
| PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis. | PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis.
Liu G, Hou Y, Jin X, Zhang Y, Sun C, Huang C, Ren Y, Gao J, Wang X, Jiang X., Free PMC Article | 07/19/2024 |
| Molecular dissection of PI3Kbeta synergistic activation by receptor tyrosine kinases, GbetaGgamma, and Rho-family GTPases. | Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases.
Duewell BR, Wilson NE, Bailey GM, Peabody SE, Hansen SD., Free PMC Article | 06/3/2024 |
| HMGB1/PTEN/PI3K axis participates in the peripheral immune cell differentiation in two representative TCM syndromes of chronic hepatitis B patients. | HMGB1/PTEN/PI3K axis participates in the peripheral immune cell differentiation in two representative TCM syndromes of chronic hepatitis B patients.
Jiang C, Li X, Liu C, Li G, Zheng Y, Xie L, Wu W, Feng Q. | 11/16/2023 |
| AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20). | AZD8186 in Combination With Paclitaxel in Patients With Advanced Gastric Cancer: Results From a Phase Ib/II Study (KCSG ST18-20).
Suh KJ, Ryu MH, Zang DY, Bae WK, Lee HS, Oh HJ, Kang M, Kim JW, Kim BJ, Mortimer PGS, Kim HJ, Lee KW., Free PMC Article | 10/16/2023 |
| Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma. | Exosomal PIK3CB promotes PD-L1 expression and malignant transformation in esophageal squamous cell carcinoma.
Xu W, Chen Y, Zhang Z, Jiang Y, Wang Z. | 07/10/2023 |
| PI3Kbeta-regulated beta-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression. | PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression.
Yadav S, Garrido A, Hernández MC, Oliveros JC, Pérez-García V, Fraga MF, Carrera AC., Free PMC Article | 10/22/2022 |
| Suppression of PI3Kp110beta Reduces Cell Viability and Induces Apoptosis in Human Esophageal Cancer. | Suppression of PI3Kp110β Reduces Cell Viability and Induces Apoptosis in Human Esophageal Cancer.
Pan D, Liao X, Tan S, Wu M, Wang X, Li M, Xu W, Jiang M, Chen G. | 10/15/2022 |
| CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells. | CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells.
Zhang L, Li Y, Hu C, Chen Y, Chen Z, Chen ZS, Zhang JY, Fang S., Free PMC Article | 05/14/2022 |
| PIP3 abundance overcomes PI3K signaling selectivity in invadopodia. | PIP(3) abundance overcomes PI3K signaling selectivity in invadopodia.
Jakubik CT, Weckerly CC, Hammond GRV, Bresnick AR, Backer JM., Free PMC Article | 03/12/2022 |
| Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis. | Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, Wolf-Ochoa MW, Martinez-Cerdeño V, Wernig M, Chen L, Klann E, Warren ST, Jin P, Wen Z, Bassell GJ., Free PMC Article | 02/19/2022 |
| PIK3CB is involved in metastasis through the regulation of cell adhesion to collagen I in pancreatic cancer. | PIK3CB is involved in metastasis through the regulation of cell adhesion to collagen I in pancreatic cancer.
Qu J, Zheng B, Ohuchida K, Feng H, Chong SJF, Zhang X, Liang R, Liu Z, Shirahane K, Mizumoto K, Gong P, Nakamura M., Free PMC Article | 01/22/2022 |
| The role of different PI3K protein subtypes in the metastasis, angiogenesis and clinical prognosis of hepatocellular carcinoma. | The role of different PI3K protein subtypes in the metastasis, angiogenesis and clinical prognosis of hepatocellular carcinoma.
Che N, Zhao X, Zhao N, Zhang Y, Ni C, Zhang D, Su S, Liang X, Li F, Li Y. | 12/18/2021 |
| Hepatitis E viral infection regulates estrogen signaling pathways: Inhibition of the cAMPK-PKA-CREB and PI3K-AKT-mTOR signaling pathways. | Hepatitis E viral infection regulates estrogen signaling pathways: Inhibition of the cAMPK-PKA-CREB and PI3K-AKT-mTOR signaling pathways.
Gong S, Hao X, Bi Y, Yang C, Wang W, Mickael HK, Zhang Y, Chen S, Qian Z, Huang F, Wei D, Yu W. | 10/9/2021 |
| Nuclear upregulation of class I phosphoinositide 3-kinase p110beta correlates with high 47S rRNA levels in cancer cells. | Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells.
Mazloumi Gavgani F, Karlsson T, Tangen IL, Morovicz AP, Arnesen VS, Turcu DC, Ninzima S, Spang K, Krakstad C, Guillermet-Guibert J, Lewis AE. | 07/24/2021 |
| Distinct epithelial-to-mesenchymal transitions induced by PIK3CA (H1047R) and PIK3CB. | Distinct epithelial-to-mesenchymal transitions induced by PIK3CA(H1047R) and PIK3CB.
Gjelaj E, Hamel PA. | 07/24/2021 |
| SUMOylation modulates the stability and function of PI3K-p110beta. | SUMOylation modulates the stability and function of PI3K-p110β.
El Motiam A, de la Cruz-Herrera CF, Vidal S, Seoane R, Baz-Martínez M, Bouzaher YH, Lecona E, Esteban M, Rodríguez MS, Vidal A, Collado M, Rivas C., Free PMC Article | 05/22/2021 |
| N(6)-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression. | N(6)-methyladenosine mRNA methylation of PIK3CB regulates AKT signalling to promote PTEN-deficient pancreatic cancer progression.
Tian J, Zhu Y, Rao M, Cai Y, Lu Z, Zou D, Peng X, Ying P, Zhang M, Niu S, Li Y, Zhong R, Chang J, Miao X. | 04/17/2021 |
| YBX1 mediates autophagy by targeting p110beta and decreasing the sensitivity to cisplatin in NSCLC. | YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
Cui Y, Li F, Xie Q, Zhao S, Guo T, Guo P, Hu S, Hao J, Tian C, Yu W, Li Z, Fang L, Zhao L, Chen M, Wu T, Gu C., Free PMC Article | 03/20/2021 |
| FAK, paxillin, and PI3K in ameloblastoma and adenomatoid odontogenic tumor. | FAK, paxillin, and PI3K in ameloblastoma and adenomatoid odontogenic tumor.
Bello IO, Alrabeeah MA, AlFouzan NF, Alabdulaali NA, Nieminen P. | 02/20/2021 |
| Inactivation of endothelial cell phosphoinositide 3-kinase beta inhibits tumor angiogenesis and tumor growth. | Inactivation of endothelial cell phosphoinositide 3-kinase β inhibits tumor angiogenesis and tumor growth.
Azad AK, Zhabyeyev P, Vanhaesebroeck B, Eitzen G, Oudit GY, Moore RB, Murray AG. | 12/12/2020 |
| AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells. | AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells.
Sinha S, Renganathan A, Nagendra PB, Bhat V, Mathew BS, Rao MRS., Free PMC Article | 11/21/2020 |
| Talc-sensitive cells have higher mRNA and protein expression of PI3K catalytic subunit beta. Both PI3Kalpha and -beta mediate talc-induced cell death and IL-6 secretion in lung carcinoma cells. | PI3K Catalytic Subunits α and β Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells.
Bougen-Zhukov NM, Lee YY, Lee JJ, Lee P, Loo LH. | 08/1/2020 |
| macropinocytosis in response to receptor tyrosine kinase activation is strikingly dependent on a single class I PI3K isoform, namely PI3Kbeta (containing the p110beta catalytic subunit encoded by PIK3CB). Loss of PI3Kbeta expression or activity blocks macropinocytosis at early steps. | PI3Kβ is selectively required for growth factor-stimulated macropinocytosis.
Salloum G, Jakubik CT, Erami Z, Heitz SD, Bresnick AR, Backer JM., Free PMC Article | 07/11/2020 |
| Expression of miR-337-3p is down-regulated in epithelial ovarian cancer (EOC) tissues and low expression of miR-337-3p is correlated with advanced pathological grade for patients. PIK3CA and PIK3CB were revealed to be direct targets of miR-337-3p. In vivo investigation confirmed that miR-337-3p is a tumor suppressor that control expression of PIK3CA and PIK3CB encoded protein: p110alpha and p110beta. | MiR-337-3p suppresses proliferation of epithelial ovarian cancer by targeting PIK3CA and PIK3CB.
Zhang Z, Zhang L, Wang B, Wei R, Wang Y, Wan J, Zhang C, Zhao L, Zhu X, Zhang Y, Chu C, Guo Q, Yin X, Li X. | 07/4/2020 |