| Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome. | Various Expressions of PIK3C2A and TXNIP Genes and Their Potential Role as Independent Risk Factors for Chronic Stable Angina and Acute Coronary Syndrome.
Soliman SE, Abouelenin MAH, Samy NI, Omar MM, Alrefai AA., Free PMC Article | 03/1/2023 |
| The molecular mechanisms mediating class II PI 3-kinase function in cell physiology. | The molecular mechanisms mediating class II PI 3-kinase function in cell physiology.
Koch PA, Dornan GL, Hessenberger M, Haucke V. | 01/15/2022 |
| PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation. | PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E., Free PMC Article | 12/25/2021 |
| Class II phosphatidylinositol 3-kinase-C2alpha is essential for Notch signaling by regulating the endocytosis of gamma-secretase in endothelial cells. | Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells.
Shimizu S, Yoshioka K, Aki S, Takuwa Y., Free PMC Article | 12/11/2021 |
| TGFbeta receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2alpha-, and INPP4B-mediated phosphoinositide conversions. | TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions.
Aki S, Yoshioka K, Takuwa N, Takuwa Y., Free PMC Article | 01/23/2021 |
| MiR-31 suppressed cell proliferation, migration, and invasion of osteosarcoma by targeting PIK3C2A expression. | MicroRNA-31 inhibits osteosarcoma cell proliferation, migration and invasion by targeting PIK3C2A.
Chao LM, Sun W, Chen H, Liu BY, Li PF, Zhao DW. | 12/7/2019 |
| the identification of the first patients with PIK3C2A deficiency establishes a role for PIK3C2A in neurological and skeletal development, as well as vision, and growth and implicates loss-of-function PIK3C2A mutations as a potentially new cause of a cilia-associated disease. | Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction.
Tiosano D, Baris HN, Chen A, Hitzert MM, Schueler M, Gulluni F, Wiesener A, Bergua A, Mory A, Copeland B, Gleeson JG, Rump P, van Meer H, Sival DA, Haucke V, Kriwinsky J, Knaup KX, Reis A, Hauer NN, Hirsch E, Roepman R, Pfundt R, Thiel CT, Wiesener MS, Aslanyan MG, Buchner DA., Free PMC Article | 10/5/2019 |
| Study illustrates that the C-terminal PX-C2 module of PI3K-C2a plays an important role in membrane anchoring, with the C2 domain providing the primary site of membrane affinity, and suggests a possible role for Ca2+ in regulating PI3K-C2a activity through perturbation of C2 domain membrane interaction. | Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2α.
Chen KE, Tillu VA, Chandra M, Collins BM. | 09/21/2019 |
| PI3K-C2alpha and PI3K-C2beta play differential, indispensable roles in clathrin-mediated pinocytosis. | The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.
Aung KT, Yoshioka K, Aki S, Ishimaru K, Takuwa N, Takuwa Y., Free PMC Article | 06/1/2019 |
| The level of PIK3C2A gene expression in patients with acute myocardial infarction is significantly lower than that of healthy people. | Low expression of PIK3C2A gene: A potential biomarker to predict the risk of acute myocardial infarction.
Tan B, Liu M, Yang Y, Liu L, Meng F., Free PMC Article | 04/13/2019 |
| PIK3C2A Polymorphism is associated with recurrence in non-small cell lung cancer. | KRAS genetic variant as a prognostic factor for recurrence in resectable non-small cell lung cancer.
Sullivan I, Salazar J, Arqueros C, Andrés M, Sebio A, Majem M, Szafranska J, Martínez E, Páez D, López-Pousa A, Baiget M, Barnadas A. | 03/31/2018 |
| Four gene signature (PTEN, PIK3C2A, ITPA and BCL3) is an independent prognostic factors of both overall survival and disease-free survival in clear-cell renal-cell carcinoma. | A four-gene signature predicts survival in clear-cell renal-cell carcinoma.
Dai J, Lu Y, Wang J, Yang L, Han Y, Wang Y, Yan D, Ruan Q, Wang S., Free PMC Article | 02/24/2018 |
| These results elucidated that PIK3C2A mRNA acts as a miR-124 decoy to regulate CD151 and to affect hepatocellular carcinoma malignant phenotypes. | PIK3C2A mRNA functions as a miR-124 sponge to facilitate CD151 expression and enhance malignancy of hepatocellular carcinoma cells.
Liu T, Zu CH, Wang SS, Song HL, Wang ZL, Xu XN, Liu HS, Wang YL, Shen ZY., Free PMC Article | 12/30/2017 |
| PIK3C2A was associated with bipolar disorder. | Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder.
Lescai F, Als TD, Li Q, Nyegaard M, Andorsdottir G, Biskopstø M, Hedemand A, Fiorentino A, O'Brien N, Jarram A, Liang J, Grove J, Pallesen J, Eickhardt E, Mattheisen M, Bolund L, Demontis D, Wang AG, McQuillin A, Mors O, Wang J, Børglum AD., Free PMC Article | 11/18/2017 |
| Results present evidence that PI3K-C2alpha is critical in the proper maturation of endosomes, and for coordinating the use of endosomes as an additional membrane source during autophagy. | PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles.
Merrill NM, Schipper JL, Karnes JB, Kauffman AL, Martin KR, MacKeigan JP., Free PMC Article | 10/14/2017 |
| miR-518a-5p was downregulated in imatinib-resistant gastrointestinal stromal tumors (GISTs), and the expression of miR-518a-5p was confirmed with good concordance between real-time PCR and miRNA microarray results. Luciferase reporter assays indicated that miR-518a-5p bound to the PIK3C2A 3'UTR. | PIK3C2A is a gene-specific target of microRNA-518a-5p in imatinib mesylate-resistant gastrointestinal stromal tumor.
Shi Y, Gao X, Hu Q, Li X, Xu J, Lu S, Liu Y, Xu C, Jiang D, Lin J, Xue A, Tan Y, Shen K, Hou Y. | 06/24/2017 |
| Therefore, PI3K-C2A is a factor important for human cytomegalovirus replication and has a role in the production of human cytomegalovirus virions. | High-Throughput Small Interfering RNA Screening Identifies Phosphatidylinositol 3-Kinase Class II Alpha as Important for Production of Human Cytomegalovirus Virions.
Polachek WS, Moshrif HF, Franti M, Coen DM, Sreenu VB, Strang BL., Free PMC Article | 05/13/2017 |
| PI3KC2a knockdown results in rerouting of insulin signaling and pancreatic beta cell proliferation. | PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation.
Leibiger B, Moede T, Paschen M, Yunn NO, Lim JH, Ryu SH, Pereira T, Berggren PO, Leibiger IB. | 07/16/2016 |
| MiR-206 regulates endothelial progenitor cell activities by targeting PIK3C2alpha expression.The role of PIK3C2alpha in endothelial progenitor cell function in coronary artery disease | Role of the microRNA, miR-206, and its target PIK3C2α in endothelial progenitor cell function – potential link with coronary artery disease.
Tang Y, Zhang Y, Chen Y, Xiang Y, Xie Y. | 04/30/2016 |
| PI3KC2alpha has a role in regulating shear-dependent platelet adhesion via regulation of membrane structure, rather than acute signalling | The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.
Mountford JK, Petitjean C, Putra HW, McCafferty JA, Setiabakti NM, Lee H, Tønnesen LL, McFadyen JD, Schoenwaelder SM, Eckly A, Gachet C, Ellis S, Voss AK, Dickins RA, Hamilton JR, Jackson SP. | 08/15/2015 |
| a model of S. flexneri dissemination is proposed in which the formation of vacuole-like protrusions is mediated by the PIK3C2A-dependent production of the signaling lipid phosphatidylinositol 3-phosphate in the protrusion membrane | The class II phosphatidylinositol 3-phosphate kinase PIK3C2A promotes Shigella flexneri dissemination through formation of vacuole-like protrusions.
Dragoi AM, Agaisse H., Free PMC Article | 07/25/2015 |
| Data (including data from knockout mice) suggest that PI3KC2a participates in tumor angiogenesis. [REVIEW] | New insight into the intracellular roles of class II phosphoinositide 3-kinases.
Maffucci T, Falasca M. | 06/6/2015 |
| These observations indicate that PI3K-C2alpha plays the pivotal role in TGFbeta receptor endocytosis and thereby Smad2/3 signaling, participating in angiogenic actions of TGFbeta. | Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells.
Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y., Free PMC Article | 05/23/2015 |
| Class II enzyme PI3K-C2beta and the class IB isozyme p110gamma mainly regulate the S1P- and high density lipoprotein (HDL)-dependent endothelial cell (EC) migration and PI3K-C2alpha primarily controls EC survival | Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis.
Tibolla G, Piñeiro R, Chiozzotto D, Mavrommati I, Wheeler AP, Norata GD, Catapano AL, Maffucci T, Falasca M., Free PMC Article | 08/31/2013 |
| PI3K-C2alpha plays the crucial role in S1P(1) internalization into the intracellular vesicular compartment, Rac1 activation on endosomes, and thereby migration through regulating vesicular trafficking in ECs | Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells.
Biswas K, Yoshioka K, Asanuma K, Okamoto Y, Takuwa N, Sasaki T, Takuwa Y., Free PMC Article | 04/6/2013 |