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    EMCN endomucin [ Homo sapiens (human) ]

    Gene ID: 51705, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Non-endothelial expression of endomucin in the mouse and human choroid.

    Non-endothelial expression of endomucin in the mouse and human choroid.
    Brookins E, Serrano SE, Hyder Z, Yacu GS, Finer G, Thomson BR.,

    09/19/2024
    Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2.

    Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2.
    Cano I, Wild M, Gupta U, Chaudhary S, Ng YSE, Saint-Geniez M, D'Amore PA, Hu Z., Free PMC Article

    04/29/2024
    MUC14-Related ncRNA-mRNA Network in Breast Cancer.

    MUC14-Related ncRNA-mRNA Network in Breast Cancer.
    Wang S, Jin J, Chen J, Lou W., Free PMC Article

    02/19/2022
    Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity.

    Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity.
    Hu Z, Cano I, Saez-Torres KL, LeBlanc ME, Saint-Geniez M, Ng YS, Argüeso P, D'Amore PA., Free PMC Article

    03/6/2021
    ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface.

    ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface.
    Yang J, LeBlanc ME, Cano I, Saez-Torres KL, Saint-Geniez M, Ng YS, D'Amore PA., Free PMC Article

    12/26/2020
    Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin.

    Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin.
    Reckzeh K, Kizilkaya H, Helbo AS, Alrich ME, Deslauriers AG, Grover A, Rapin N, Asmar F, Grønbæk K, Porse B, Borregaard N, Vestweber D, Nerlov C, Theilgaard-Mönch K., Free PMC Article

    04/6/2019
    In contrast, endomucin (EMCN) is present on the lymphatic sinus endothelium and not on lymphatic endothelium of the subcapsular sinus. Moreover, both murine and human MSR1 on lymphatic endothelium of the SS bind lymphocytes and in in vivo studies MSR1 regulates entrance of lymphocytes from the SS to the lymph node parenchyma

    Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic.
    Iftakhar-E-Khuda I, Fair-Mäkelä R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S., Free PMC Article

    01/27/2018
    These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.

    Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions.
    Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P., Free PMC Article

    06/28/2016
    Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation.

    Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression.
    Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T., Free PMC Article

    09/17/2011
    A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis.

    Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population.
    Nishimoto K, Ikari K, Kaneko H, Tsukahara S, Kochi Y, Yamamoto K, Nakamura Y, Toyama Y, Taniguchi A, Yamanaka H, Momohara S.

    07/2/2011
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
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