| PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation. | PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation.
An S, Yao Y, Hu H, Wu J, Li J, Li L, Wu J, Sun M, Deng Z, Zhang Y, Gong S, Huang Q, Chen Z, Zeng Z., Free PMC Article | 07/25/2023 |
| T Cells Mediate Kidney Tubular Injury via Impaired PDHA1 and Autophagy in Type 1 Diabetes. | T Cells Mediate Kidney Tubular Injury via Impaired PDHA1 and Autophagy in Type 1 Diabetes.
Wang CH, Lu WL, Chiang SL, Tsai TH, Liu SC, Hsieh CH, Su PH, Huang CY, Tsai FJ, Lin YJ, Huang YN. | 08/27/2022 |
| MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1alpha promotes tumour immune evasion. | MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion.
Zhang Y, Zhao M, Gao H, Yu G, Zhao Y, Yao F, Yang W. | 05/7/2022 |
| Pyruvate Dehydrogenase Complex Deficiency Due to PDHA1 Mutation-A Rare Treatable Cause for Episodic Ataxia in Children. | Pyruvate Dehydrogenase Complex Deficiency Due to PDHA1 Mutation-A Rare Treatable Cause for Episodic Ataxia in Children.
Pavuluri H, F A, Menon RN, Nair SS, Sundaram S. | 04/23/2022 |
| Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes. | Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes.
Zaher DM, Talaat IM, Hussein A, Hachim MY, Omar HA. | 10/9/2021 |
| Novel presentations associated with a PDHA1 variant - Alternating hemiplegia in Hemizygote proband and Guillain Barre Syndrome in Heterozygote mother. | Novel presentations associated with a PDHA1 variant - Alternating hemiplegia in Hemizygote proband and Guillain Barre Syndrome in Heterozygote mother.
Sen K, Grahame G, Bedoyan JK, Gropman AL., Free PMC Article | 06/19/2021 |
| Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. | Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis.
Cai Z, Li CF, Han F, Liu C, Zhang A, Hsu CC, Peng D, Zhang X, Jin G, Rezaeian AH, Wang G, Zhang W, Pan BS, Wang CY, Wang YH, Wu SY, Yang SC, Hsu FC, D'Agostino RB Jr, Furdui CM, Kucera GL, Parks JS, Chilton FH, Huang CY, Tsai FJ, Pasche B, Watabe K, Lin HK., Free PMC Article | 10/31/2020 |
| LDHA/PDHA1 changes in Head and Neck Squamous Cell Carcinoma (HNSCC) resulted in a broad metabolic reprogramming while intracellular molecules including polyunsaturated fatty acids and nitrogen metabolism related metabolites underlie the malignant changes. | Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis.
Chen TY, Hsieh YT, Huang JM, Liu CJ, Chuang LT, Huang PC, Kuo TY, Chia HY, Chou CY, Chang CW, Chen YF, Chen HM, Lo JF, Li WC., Free PMC Article | 12/21/2019 |
| PGC1alpha reversed the Warburg effect by upregulating the expression of pyruvate dehydrogenase E1 alpha 1 subunit and mitochondrial pyruvate carrier 1 to increase pyruvate flux into the mitochondria for oxidation, whereas simultaneously promoting mitochondrial biogenesis and fusion to mediate the metabolic switch to oxidative phosphorylation. | PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect.
Dan Li, Wang C, Ma P, Yu Q, Gu M, Dong L, Jiang W, Pan S, Xie C, Han J, Lan Y, Sun J, Sheng P, Liu K, Wu Y, Liu L, Ma Y, Jiang H., Free PMC Article | 11/9/2019 |
| We demonstrate here that silencing of PDHA1 expression prevents proliferation of HUVECs and inhibits angiogenesis in vitro as well as in vivo | The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis.
Yetkin-Arik B, Vogels IMC, Nowak-Sliwinska P, Weiss A, Houtkooper RH, Van Noorden CJF, Klaassen I, Schlingemann RO., Free PMC Article | 10/7/2019 |
| insulin-mediated p-PDHA1 is involved in the regulation of HepG2 cell proliferation through RhoA signaling pathway. | Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells.
Islam R, Kim JG, Park Y, Cho JY, Cap KC, Kho AR, Chung WS, Suh SW, Park JB. | 08/10/2019 |
| Both mitochondrial and nuclear Pyruvate dehydrogenase complex sustain prostate tumorigenesis by controlling lipid biosynthesis, thus suggesting this complex as a potential target for cancer therapy. | Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.
Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, Pasquini E, Alajati A, Pinton S, Losa M, Civenni G, Catapano CV, Sgrignani J, Cavalli A, D'Antuono R, Asara JM, Morandi A, Chiarugi P, Crotti S, Agostini M, Montopoli M, Masgras I, Rasola A, Garcia-Escudero R, Delaleu N, Rinaldi A, Bertoni F, Bono J, Carracedo A, Alimonti A., Free PMC Article | 05/18/2019 |
| our data indicate that reduced PDHA1 protein expression is associated with the poor clinical outcome of HCC. Upregulated PDHA1 gene expression can inhibit the Warburg effect and enhance the mitochondria-mediated apoptosis pathway. | Overexpression of Pyruvate Dehydrogenase E1α Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma.
Sun J, Li J, Guo Z, Sun L, Juan C, Zhou Y, Gu H, Yu Y, Hu Q, Kan Q, Yu Z., Free PMC Article | 04/27/2019 |
| PDHA1 (P = 0.025) was an independent predictor of overall survival in gastric cancer | Low expression of PDHA1 predicts poor prognosis in gastric cancer.
Song L, Liu D, Zhang X, Zhu X, Lu X, Huang J, Yang L, Wu Y. | 04/13/2019 |
| PDHc E1 mutation i9s associated with Pyruvate dehydrogenase complex deficiency. | Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the αV138M variant of human pyruvate dehydrogenase.
Whitley MJ, Arjunan P, Nemeria NS, Korotchkina LG, Park YH, Patel MS, Jordan F, Furey W., Free PMC Article | 03/2/2019 |
| Case demonstrates fetal akinesia deformation sequence due to a de novo hemizygous c.498C > T splice-site mutation in the pyruvate dehydrogenase-alpha 1 (PDHA1) gene. | Massive parallel sequencing identifies RAPSN and PDHA1 mutations causing fetal akinesia deformation sequence.
Winters L, Van Hoof E, De Catte L, Van Den Bogaert K, de Ravel T, De Waele L, Corveleyn A, Breckpot J. | 03/31/2018 |
| Data show that metformin reduces hypoxia-inducible factor 1alpha (HIF-1alpha) gene expression and increases pyruvate dehydrogenase (PDH) expression. | Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma.
Guimarães TA, Farias LC, Santos ES, de Carvalho Fraga CA, Orsini LA, de Freitas Teles L, Feltenberger JD, de Jesus SF, de Souza MG, Santos SH, de Paula AM, Gomez RS, Guimarães AL., Free PMC Article | 01/20/2018 |
| The report PDHA1 as a new component of brainstem-type Lewy bodies in idiopathic PD, DLB and PARK14, the level of PDHA1 protein being significantly decreased in the putamen and substantia nigra of patients with idiopathic Parkinson's disease . | Alteration of mitochondrial protein PDHA1 in Lewy body disease and PARK14.
Miki Y, Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K. | 09/23/2017 |
| Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation. | NOK mediates glycolysis and nuclear PDC associated histone acetylation.
Shi WY, Yang X, Huang B, Shen WH, Liu L. | 09/2/2017 |
| The association of mitochondrial microphthalmia-associated transcription factor (MITF) with pyruvate dehydrogenase (PDH) emerges as an important regulator of mast cell function. Our findings indicate that PDH could arise as a new target for the manipulation of allergic diseases. | Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor.
Sharkia I, Hadad Erlich T, Landolina N, Assayag M, Motzik A, Rachmin I, Kay G, Porat Z, Tshori S, Berkman N, Levi-Schaffer F, Razin E. | 09/2/2017 |
| our results show that negative PDHA1 gene expressionis associated with significantly higher cell stemness in prostate cancer cells and reduced protein expression of this gene is associated with shorter clinical outcome in prostate cancers. | Pyruvate dehydrogenase expression is negatively associated with cell stemness and worse clinical outcome in prostate cancers.
Zhong Y, Li X, Ji Y, Li X, Li Y, Yu D, Yuan Y, Liu J, Li H, Zhang M, Ji Z, Fan D, Wen J, Goscinski MA, Yuan L, Hao B, Nesland JM, Suo Z., Free PMC Article | 08/26/2017 |
| oncoprotein HBXIP enhances glucose metabolism reprogramming through suppressing SCO2 and PDHA1 in breast cancer | The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L., Free PMC Article | 08/20/2016 |
| Lack of PDHE1alpha protein expression is associated with Esophageal Squamous Cell Carcinoma. | Decreased Expression of PDHE1α Predicts Worse Clinical Outcome in Esophageal Squamous Cell Carcinoma.
Zhong Y, Huang R, Li X, Xu R, Zhou F, Wang J, Fan H, Goscinski M, Zhang M, Wen JG, Nesland JM, Suo Z. | 01/16/2016 |
| MPO and BPI in CD4(+)T-lymphocytes, and PDHA1 and MRPL42 in CD8(+) T-lymphocytes might be used as specific biomarkers of severe asthma progression. | [Comparative analysis of the role of CD4(+) and CD8(+) T cells in severe asthma development].
Wang X, Wang J, Xing CY, Zang R, Pu YY, Yin ZX. | 08/15/2015 |
| Phosphorylation at distinct serine and tyrosine residues inhibits PDHA1 through distinct mechanisms to impact active site accessibility. | Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.
Fan J, Kang HB, Shan C, Elf S, Lin R, Xie J, Gu TL, Aguiar M, Lonning S, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Kang S, Chen J., Free PMC Article | 02/7/2015 |