| Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis. | Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis.
Lacedonia D, Scioscia G, Soccio P, Conese M, Catucci L, Palladino GP, Simone F, Quarato CMI, Di Gioia S, Rana R, Sollitto F, Foschino-Barbaro MP., Free PMC Article | 11/6/2021 |
| Solanine inhibits proliferation and promotes apoptosis of the human leukemia cells by targeting the miR-16/Bcl-2 axis. | Solanine inhibits proliferation and promotes apoptosis of the human leukemia cells by targeting the miR-16/Bcl-2 axis.
Zheng Y, Li L, Gao Q, Niu B, Wang H. | 02/13/2021 |
| Long Noncoding RNA DLX6-AS1 Promotes the Progression in Cervical Cancer by Targeting miR-16-5p/ARPP19 Axis. | Long Noncoding RNA DLX6-AS1 Promotes the Progression in Cervical Cancer by Targeting miR-16-5p/ARPP19 Axis.
Xie F, Xie G, Sun Q. | 11/28/2020 |
| this study shows that HTR$ gene expression regulation is affected by mir-16 and mir-103 single nucleotide polymorphisms | miR-16 and miR-103 impact 5-HT(4) receptor signalling and correlate with symptom profile in irritable bowel syndrome.
Wohlfarth C, Schmitteckert S, Härtle JD, Houghton LA, Dweep H, Fortea M, Assadi G, Braun A, Mederer T, Pöhner S, Becker PP, Fischer C, Granzow M, Mönnikes H, Mayer EA, Sayuk G, Boeckxstaens G, Wouters MM, Simrén M, Lindberg G, Ohlsson B, Schmidt PT, Dlugosz A, Agreus L, Andreasson A, D'Amato M, Burwinkel B, Bermejo JL, Röth R, Lasitschka F, Vicario M, Metzger M, Santos J, Rappold GA, Martinez C, Niesler B., Free PMC Article | 08/17/2019 |
| Sera samples from inflammatory bowel disease (IBD) patients showed higher level of miR-16, miR-21, and miR-223, but not miR-155, compared to controls and was higher in Crohn's disease (CD) than in ulcerative colitis (UC) patients. | Circulating and Fecal microRNAs as Biomarkers for Inflammatory Bowel Diseases.
Schönauen K, Le N, von Arnim U, Schulz C, Malfertheiner P, Link A. | 07/20/2019 |
| Study demonstrated that puerarin could inhibit cell proliferation, promote cell apoptosis, and deactivate NF-kappaB signaling pathway via upregulation of miR-16 in T24 cells | Puerarin Inhibits Proliferation and Induces Apoptosis by Upregulation of miR-16 in Bladder Cancer Cell Line T24.
Liu X, Li S, Li Y, Cheng B, Tan B, Wang G., Free PMC Article | 12/22/2018 |
| MiR15a/16 inhibited the components of TGF-beta signaling pathways. | miR-15a/miR-16 cluster inhibits invasion of prostate cancer cells by suppressing TGF-β signaling pathway.
Jin W, Chen F, Wang K, Song Y, Fei X, Wu B. | 10/6/2018 |
| Our outcomes suggest that miR-15a/16 maintain the retinal endothelial cell barrier by reducing TGFbeta3/VEGF signaling and increasing levels of key tight junction proteins. | miR-15a/16 inhibits TGF-beta3/VEGF signaling and increases retinal endothelial cell barrier proteins.
Ye EA, Liu L, Steinle JJ., Free PMC Article | 04/21/2018 |
| The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. | TYRP1 mRNA goes fishing for miRNAs in melanoma.
Soengas MS, Hernando E. | 11/11/2017 |
| we identified cyclin J and far upstream element-binding protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16 antiproliferative effects. | MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1.
Venturutti L, Cordo Russo RI, Rivas MA, Mercogliano MF, Izzo F, Oakley RH, Pereyra MG, De Martino M, Proietti CJ, Yankilevich P, Roa JC, Guzmán P, Cortese E, Allemand DH, Huang TH, Charreau EH, Cidlowski JA, Schillaci R, Elizalde PV., Free PMC Article | 09/9/2017 |
| miR-15a/16 may function as a tumor suppressor in MM through multiple regulatory mechanisms | MiR-15a/16 regulates the growth of myeloma cells, angiogenesis and antitumor immunity by inhibiting Bcl-2, VEGF-A and IL-17 expression in multiple myeloma.
Li Y, Zhang B, Li W, Wang L, Yan Z, Li H, Yao Y, Yao R, Xu K, Li Z. | 07/22/2017 |
| The expression levels of two target genes, Myb and VEGFR2, were affected significantly by miR-16, while glucose administration inhibited miR-16 expression and enhanced tumor cell proliferation and migration. | High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2.
Yang IP, Tsai HL, Huang CW, Lu CY, Miao ZF, Chang SF, Juo SH, Wang JY., Free PMC Article | 02/4/2017 |
| Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 expression and instability of claudin-2 mRNA in lung adenocarcinoma cells. | Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells.
Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A., Free PMC Article | 05/7/2016 |
| Our data indicate differential concentrations of plasma miR-16, miR-107, miR-130a and miR-146a in different breast cancer subtypes, suggesting a potential role of these miRs in breast cancer biology and tumor progression. | Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients.
Stückrath I, Rack B, Janni W, Jäger B, Pantel K, Schwarzenbach H., Free PMC Article | 04/9/2016 |
| YAP1 was confirmed to be a functional target of miR-15a and miR-16-1 in GAC. | Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma.
Kang W, Tong JH, Lung RW, Dong Y, Zhao J, Liang Q, Zhang L, Pan Y, Yang W, Pang JC, Cheng AS, Yu J, To KF., Free PMC Article | 01/16/2016 |
| miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress. | miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress.
Lezina L, Purmessur N, Antonov AV, Ivanova T, Karpova E, Krishan K, Ivan M, Aksenova V, Tentler D, Garabadgiu AV, Melino G, Barlev NA., Free PMC Article | 06/14/2014 |
| Up-regulation of miR-16 is associated with triple negative breast cancer. | Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer.
Cascione L, Gasparini P, Lovat F, Carasi S, Pulvirenti A, Ferro A, Alder H, He G, Vecchione A, Croce CM, Shapiro CL, Huebner K., Free PMC Article | 08/31/2013 |
| This study demonistrated that miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients. | miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients.
Lorenzi JC, Brum DG, Zanette DL, de Paula Alves Souza A, Barbuzano FG, Dos Santos AC, Barreira AA, da Silva WA. | 12/8/2012 |
| miR-16 and miR-21 are directly regulated by the transcription factor NF-kappaB and yet nicotine-promoted cell proliferation is mediated via EP2/4 receptors. | NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors.
Shin VY, Jin H, Ng EK, Cheng AS, Chong WW, Wong CY, Leung WK, Sung JJ, Chu KM. | 03/12/2011 |
| Results suggest an important role of miR-16 in the regulation of Wip1 phosphatase in the DNA damage response and mammary tumorigenesis. | Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway.
Zhang X, Wan G, Mlotshwa S, Vance V, Berger FG, Chen H, Lu X., Free PMC Article | 10/23/2010 |
| These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions in patients with multiple myeloma | Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma.
Corthals SL, Jongen-Lavrencic M, de Knegt Y, Peeters JK, Beverloo HB, Lokhorst HM, Sonneveld P. | 05/3/2010 |
| Glycerophosphodiesterase has robust activity on glycerophospho-N-acyl ethanolamines (GP-NAEs) which are precursors for the N-acyl ethanolamines including the endocannabinoid anandamide. Thus, GDE1 may participate in anandamide biosynthesis. | Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.
Simon GM, Cravatt BF., Free PMC Article | 04/9/2008 |
| regulation by by stimulation of G protein-coupled receptors | GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors.
Zheng B, Berrie CP, Corda D, Farquhar MG., Free PMC Article | 01/21/2010 |