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    UFC1 ubiquitin-fold modifier conjugating enzyme 1 [ Homo sapiens (human) ]

    Gene ID: 51506, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Dynamical Analysis of a Boolean Network Model of the Oncogene Role of lncRNA ANRIL and lncRNA UFC1 in Non-Small Cell Lung Cancer.

    Dynamical Analysis of a Boolean Network Model of the Oncogene Role of lncRNA ANRIL and lncRNA UFC1 in Non-Small Cell Lung Cancer.
    Gupta S, Hashimoto RF., Free PMC Article

    05/7/2022
    Structural basis for UFM1 transfer from UBA5 to UFC1.

    Structural basis for UFM1 transfer from UBA5 to UFC1.
    Kumar M, Padala P, Fahoum J, Hassouna F, Tsaban T, Zoltsman G, Banerjee S, Cohen-Kfir E, Dessau M, Rosenzweig R, Isupov MN, Schueler-Furman O, Wiener R., Free PMC Article

    10/23/2021
    A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1.

    A Concerted Action of UBA5 C-Terminal Unstructured Regions Is Important for Transfer of Activated UFM1 to UFC1.
    Wesch N, Löhr F, Rogova N, Dötsch V, Rogov VV., Free PMC Article

    08/14/2021
    Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression.

    Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression.
    Zang X, Gu J, Zhang J, Shi H, Hou S, Xu X, Chen Y, Zhang Y, Mao F, Qian H, Zhu T, Xu W, Zhang X., Free PMC Article

    04/13/2021
    UFC1 has a promoting role in GC progression, at least in part, by acting as a miR-498 sponge and derepressing Lin28b expression, which would provide a novel biomarker for GC diagnosis and prognosis and offer a potential target for GC therapy.

    Long non-coding RNA UFC1 promotes gastric cancer progression by regulating miR-498/Lin28b.
    Zhang X, Liang W, Liu J, Zang X, Gu J, Pan L, Shi H, Fu M, Huang Z, Zhang Y, Qian H, Jiang P, Xu W., Free PMC Article

    05/11/2019
    that UFC1 regulates survival of Osteoarthritis chondrocytes through physically association with miR-34a

    Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a.
    Zhang G, Wu Y, Xu D, Yan X.

    02/18/2017
    Autoantibodies binding to Ufc1 were found in 19 of 29 patients (66%) with active mycobacterial infections.

    Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections.
    Tellermann A, Witte T, Lansche C, Stoll M, Schmidt RE, Baerlecken NT.

    08/29/2015
    Uba5 residues 364-404 were demonstrated to be necessary for the transthiolation of Ufm1 to Ufc1, and Uba5 381-404 was identified to be the minimal region for Ufc1 recognition

    Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex.
    Xie S., Free PMC Article

    04/4/2015
    UFC1 interact with the mRNA stabilizing protein HuR to increase levels of beta-catenin in hepatocellular carcinoma.

    The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells.
    Cao C, Sun J, Zhang D, Guo X, Xie L, Li X, Wu D, Liu L.

    03/28/2015
    NCAM140 interacts with ufc1 and its trafficking and endocytosis is upregulated in the presense of Ufm1.

    Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1).
    Homrich M, Wobst H, Laurini C, Sabrowski J, Schmitz B, Diestel S.

    07/12/2014
    The structure of human Ufc1 was solved by using both NMR spectroscopy and X-ray crystallography

    NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.
    Liu G, Forouhar F, Eletsky A, Atreya HS, Aramini JM, Xiao R, Huang YJ, Abashidze M, Seetharaman J, Liu J, Rost B, Acton T, Montelione GT, Hunt JF, Szyperski T., Free PMC Article

    01/21/2010
    Identification of a novel enzyme called UFC1 for Ufm1-conjugating enzyme 1.

    A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier.
    Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K., Free PMC Article

    03/24/2005
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