| Circ-IP6K2 suppresses tumor progression by modulating the miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma. | Circ-IP6K2 suppresses tumor progression by modulating the miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma.
Tang JY, Yang L, Wu QJ, Yang Y, Su YY, Chen YR, Mu J. | 07/31/2024 |
| Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with amyotrophic lateral sclerosis. | Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with amyotrophic lateral sclerosis.
Nagata E, Fujii N, Kohara S, Okada C, Satoh T, Takekoshi S, Takao M, Mihara B, Takizawa S. | 05/29/2021 |
| LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR-339-3p/IP6K2 axis. | LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR-339-3p/IP6K2 axis.
Liang R, Tang Y. | 01/23/2021 |
| conclude that IP6K1 and -2 together control inositol pyrophosphate metabolism and thereby physiologically regulate phosphate export and other aspects of mammalian cellular phosphate homeostasis | The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.
Wilson MS, Jessen HJ, Saiardi A., Free PMC Article | 04/4/2020 |
| An alpha-helical pair and a rare, two-turn 310 helix, that together form a substrate-binding pocket of IP6K2. | IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family.
Wang H, DeRose EF, London RE, Shears SB., Free PMC Article | 11/21/2015 |
| FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. | The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade.
Niger C, Luciotti MA, Buo AM, Hebert C, Ma V, Stains JP., Free PMC Article | 12/14/2013 |
| Genetic polymorphisms in IP6K2 gene is associated with autoimmune disease. | Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.
Fairfax BP, Makino S, Radhakrishnan J, Plant K, Leslie S, Dilthey A, Ellis P, Langford C, Vannberg FO, Knight JC., Free PMC Article | 07/7/2012 |
| Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. | Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.
Chakraborty A, Werner JK Jr, Koldobskiy MA, Mustafa AK, Juluri KR, Pietropaoli J, Snowman AM, Snyder SH., Free PMC Article | 04/2/2011 |
| Gene disruption of IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets | p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.
Koldobskiy MA, Chakraborty A, Werner JK Jr, Snowman AM, Juluri KR, Vandiver MS, Kim S, Heletz S, Snyder SH., Free PMC Article | 02/5/2011 |
| InsP6K2 is a physiologic mediator of cell death | Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.
Nagata E, Luo HR, Saiardi A, Bae BI, Suzuki N, Snyder SH. | 01/21/2010 |
| IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappaB-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. | Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation.
Morrison BH, Bauer JA, Lupica JA, Tang Z, Szugye H, DiDonato JA, Lindner DJ., Free PMC Article | 01/21/2010 |
| IHPK2 over expression enhances sensitivity of ovarian carcinoma cells to radiation, IFN-beta, caspase 8 and DR4 | Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics.
Morrison BH, Bauer JA, Hu J, Grane RW, Ozdemir AM, Chawla-Sarkar M, Gong B, Almasan A, Kalvakolanu DV, Lindner DJ., Free PMC Article | 01/21/2010 |