| LncRNA-ENST00000421645 promotes T cells to secrete IFN-gamma by sponging PCM1 in neurosyphilis. | LncRNA-ENST00000421645 promotes T cells to secrete IFN-γ by sponging PCM1 in neurosyphilis.
Liu WN, Wu KX, Wang XT, Lin LR, Tong ML, Liu LL. | 03/26/2022 |
| PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. | PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
Monroe TO, Garrett ME, Kousi M, Rodriguiz RM, Moon S, Bai Y, Brodar SC, Soldano KL, Savage J, Hansen TF, Muzny DM, Gibbs RA, Barak L, Sullivan PF, Ashley-Koch AE, Sawa A, Wetsel WC, Werge T, Katsanis N., Free PMC Article | 12/12/2020 |
| SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis. | SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.
Wang P, Xia J, Zhang L, Zhao S, Li S, Wang H, Cheng S, Li H, Yin W, Pei D, Shu X., Free PMC Article | 08/22/2020 |
| study reveals that USP9X is a constituent of centriolar satellites and functions to maintain centriolar satellite integrity by stabilizing PCM1. | Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.
Han KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CW., Free PMC Article | 02/15/2020 |
| detecting PDGFRA, PDGFRB, FGFR1 and PCM1-JAK2 rearrangements is a prerequisite for up-to-date WHO classification, and an essential step in the differential diagnosis of neoplasms with eosinophilia. | Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2.
Baer C, Muehlbacher V, Kern W, Haferlach C, Haferlach T., Free PMC Article | 10/5/2019 |
| In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly. | Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis.
Wang L, Lee K, Malonis R, Sanchez I, Dynlacht BD., Free PMC Article | 11/4/2017 |
| Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein) | The X-linked deubiquitinase USP9X is an integral component of centrosome.
Wang Q, Tang Y, Xu Y, Xu S, Jiang Y, Dong Q, Zhou Y, Ge W., Free PMC Article | 08/26/2017 |
| a novel variant in the PCM1 3'UTR is significantly associated with ovarian cancer | Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer.
Chen X, Paranjape T, Stahlhut C, McVeigh T, Keane F, Nallur S, Miller N, Kerin M, Deng Y, Yao X, Zhao H, Weidhaas JB, Slack FJ., Free PMC Article | 08/1/2015 |
| no association between the PCM1 gene and schizophrenia in a Japanese population | Four polymorphisms of the pericentriolar material 1 (PCM1) gene are not associated with schizophrenia in a Japanese population.
Sakamoto S, Takaki M, Okahisa Y, Mizuki Y, Kodama M, Ujike H, Uchitomi Y. | 11/8/2014 |
| Haematological neoplasms associated with t(8;9)(p22;p24); PCM1-JAK2 have features in common and we suggest that they should be recognized as a specific entity in the WHO classification | Should myeloid and lymphoid neoplasms with PCM1-JAK2 and other rearrangements of JAK2 be recognized as specific entities?
Bain BJ, Ahmad S. | 10/25/2014 |
| these data suggest a mechanism whereby the recruitment of Plk1 to pericentriolar matrix by PCM1 plays a pivotal role in the regulation of primary cilia disassembly before mitotic entry. | PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry.
Wang G, Chen Q, Zhang X, Zhang B, Zhuo X, Liu J, Jiang Q, Zhang C. | 12/21/2013 |
| Chromosomal translocation [t(8;9)(p22;p24)]/PCM1-JAK2 fusion protein activates SOCS2 and SOCS3 via STAT5 in a cutaneous T-cell lymphoma cell line. | t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5.
Ehrentraut S, Nagel S, Scherr ME, Schneider B, Quentmeier H, Geffers R, Kaufmann M, Meyer C, Prochorec-Sobieszek M, Ketterling RP, Knudson RA, Feldman AL, Kadin ME, Drexler HG, MacLeod RA., Free PMC Article | 07/27/2013 |
| CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation. | CEP90 is required for the assembly and centrosomal accumulation of centriolar satellites, which is essential for primary cilia formation.
Kim K, Lee K, Rhee K., Free PMC Article | 04/27/2013 |
| PCM1 interacts with Hook2 in a complex that regulates a limiting step required for further initiation of ciliogenesis after centriole maturation. | Hook2 is involved in the morphogenesis of the primary cilium.
Baron Gaillard CL, Pallesi-Pocachard E, Massey-Harroche D, Richard F, Arsanto JP, Chauvin JP, Lecine P, Krämer H, Borg JP, Le Bivic A., Free PMC Article | 04/14/2012 |
| NEK7 is essential for PCM accumulation in a cell cycle stage-specific manner. | NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells.
Kim S, Kim S, Rhee K. | 04/7/2012 |
| WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1). | Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
Keryer G, Pineda JR, Liot G, Kim J, Dietrich P, Benstaali C, Smith K, Cordelières FP, Spassky N, Ferrante RJ, Dragatsis I, Saudou F., Free PMC Article | 01/7/2012 |
| The data failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>0.28). | No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis.
Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M. | 12/10/2011 |
| These data provide further evidence that PCM1-though certainly not a major risk factor in the Northern Swedish population-cannot be ruled out as a contributor to schizophrenia risk and/or protection. | PCM1 and schizophrenia: a replication study in the Northern Swedish population.
Moens LN, Ceulemans S, Alaerts M, Van Den Bossche MJ, Lenaerts AS, De Zutter S, Norrback KF, Adolfsson R, Del-Favero J, Moens LN, Ceulemans S, Alaerts M, Van Den Bossche MJ, Lenaerts AS, De Zutter S, Norrback KF, Adolfsson R, Del-Favero J. | 12/11/2010 |
| DISC1 coding variants modulate centrosomal PCM1 localization, highlight a role for DISC1 in glial function and provide a possible cellular mechanism contributing to the association of these DISC1 variants with psychiatric phenotypes. | The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain.
Eastwood SL, Walker M, Hyde TM, Kleinman JE, Harrison PJ., Free PMC Article | 08/30/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | PCM1 and schizophrenia: a replication study in the Northern Swedish population.
Moens LN, Ceulemans S, Alaerts M, Van Den Bossche MJ, Lenaerts AS, De Zutter S, Norrback KF, Adolfsson R, Del-Favero J, Moens LN, Ceulemans S, Alaerts M, Van Den Bossche MJ, Lenaerts AS, De Zutter S, Norrback KF, Adolfsson R, Del-Favero J. | 06/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Hook3- and PCM1-mediated dynamic assembly of pericentriolar material is essential for interkinetic nuclear migration. | Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis.
Ge X, Frank CL, Calderon de Anda F, Tsai LH., Free PMC Article | 03/15/2010 |
| decreased colocalization of DISC1 and its binding partner PCM1 after Phe607 DISC1 transfection | DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release.
Eastwood SL, Hodgkinson CA, Harrison PJ. | 01/21/2010 |
| cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch and a coordination of the two evolutional changes may play a role in leukemic cell progression | Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia.
Huang KP, Chase AJ, Cross NCP, Reiter A, Li TY, Wang TF, Chu SC, Lu XY, Li CC, Kao RH. | 01/21/2010 |
| CEP290 binds to PCM-1 and localizes to centriolar satellites in a PCM-1- and microtubule-dependent manner. | CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium.
Kim J, Krishnaswami SR, Gleeson JG., Free PMC Article | 01/21/2010 |