| Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV). | Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA Vasculitis (IgAV).
Held M, Kozmar A, Sestan M, Turudic D, Kifer N, Srsen S, Gagro A, Frkovic M, Jelusic M., Free PMC Article | 05/7/2024 |
| PCDH1 promotes progression of pancreatic ductal adenocarcinoma via activation of NF-kappaB signalling by interacting with KPNB1. | PCDH1 promotes progression of pancreatic ductal adenocarcinoma via activation of NF-κB signalling by interacting with KPNB1.
Ye Z, Yang Y, Wei Y, Li L, Wang X, Zhang J., Free PMC Article | 07/30/2022 |
| identification of the human asthma-associated gene protocadherin-1 as an essential determinant of entry and infection in pulmonary endothelial cells by two hantaviruses that cause hantavirus pulmonary syndrome, Andes virus and Sin Nombre virus; the surface glycoproteins of ANDV and SNV directly recognize the outermost extracellular repeat domain of PCDH1-a member of the cadherin superfamily--to exploit PCDH1 for entry | Protocadherin-1 is essential for cell entry by New World hantaviruses.
Jangra RK, Herbert AS, Li R, Jae LT, Kleinfelter LM, Slough MM, Barker SL, Guardado-Calvo P, Román-Sosa G, Dieterle ME, Kuehne AI, Muena NA, Wirchnianski AS, Nyakatura EK, Fels JM, Ng M, Mittler E, Pan J, Bharrhan S, Wec AZ, Lai JR, Sidhu SS, Tischler ND, Rey FA, Moffat J, Brummelkamp TR, Wang Z, Dye JM, Chandran K., Free PMC Article | 05/25/2019 |
| Results show that PCDH1 is localized to the cell membrane of bronchial epithelial cells basolateral to the adherens junction. Its expression is not reduced nor delocalized in asthma even though PCDH1 contributes to homotypic adhesion, epithelial barrier formation and repair. | Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma.
Faura Tellez G, Willemse BW, Brouwer U, Nijboer-Brinksma S, Vandepoele K, Noordhoek JA, Heijink I, de Vries M, Smithers NP, Postma DS, Timens W, Wiffen L, van Roy F, Holloway JW, Lackie PM, Nawijn MC, Koppelman GH., Free PMC Article | 06/24/2017 |
| PCDH1 is important for airway function as a physical barrier, and its dysfunction is involved in the pathogenesis of allergic airway inflammation. | Protocadherin-1 is a glucocorticoid-responsive critical regulator of airway epithelial barrier function.
Kozu Y, Gon Y, Maruoka S, Kazumichi K, Sekiyama A, Kishi H, Nomura Y, Ikeda M, Hashimoto S., Free PMC Article | 03/19/2016 |
| PCDH1 and SMAD3 act in a single pathway in asthma susceptibility that affects sensitivity of the airway epithelium to TGF-beta. | Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription.
Faura Tellez G, Vandepoele K, Brouwer U, Koning H, Elderman RM, Hackett TL, Willemse BW, Holloway J, Van Roy F, Koppelman GH, Nawijn MC., Free PMC Article | 01/16/2016 |
| Common variations in PCDH1 increase the risk of developing both transient early asthma and atopic dermatitis in early childhood | The PCDH1 gene and asthma in early childhood.
Mortensen LJ, Kreiner-Møller E, Hakonarson H, Bønnelykke K, Bisgaard H. | 11/8/2014 |
| genetic polymorphism is associated with subphenotypes of asthma in German children | Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children.
Toncheva AA, Suttner K, Michel S, Klopp N, Illig T, Balschun T, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, von Mutius E, Kabesch M. | 04/20/2013 |
| PCDH1 gene variant IVS3-116 associates with eczema in two independent birth cohorts in Netherlands. | Protocadherin-1 polymorphisms are associated with eczema in two Dutch birth cohorts.
Koning H, Postma DS, Brunekreef B, Duiverman EJ, Smit HA, Thijs C, Penders J, Kerkhof M, Koppelman GH. | 08/18/2012 |
| PCDH1 transcripts display remarkable variability in expression of conserved intracellular signaling domains; enhanced PCDH1 expression levels strongly correlate with differentiation of bronchial epithelial cells. | Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation.
Koning H, Sayers I, Stewart CE, de Jong D, Ten Hacken NH, Postma DS, van Oosterhout AJ, Nawijn MC, Koppelman GH. | 03/3/2012 |
| PCDH1 is a novel gene for BHR in adults and children. Its identification as a BHR susceptibility gene may suggest that a structural defect in the integrity of the airway epithelium and contributes to the development of BHR. | Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.
Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Nolte IM, van Diemen CC, Boezen HM, Timens W, Whittaker PA, Stine OC, Barton SJ, Holloway JW, Holgate ST, Graves PE, Martinez FD, van Oosterhout AJ, Bleecker ER, Postma DS., Free PMC Article | 01/21/2010 |