| SCP3 is associated with lymphangiogenesis and provides insight into the SCP3-VEGF-C/VEGF-D axis based cancer therapy strategy. | Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis.
Kitano H, Chung JY, Noh KH, Lee YH, Kim TW, Lee SH, Eo SH, Cho HJ, Choi CH, Inoue S, Hanaoka J, Fukuoka J, Hewitt SM., Free PMC Article | 03/31/2018 |
| In the model, the reported compaction of chromosomal DNA caused by SYCP3 would result from its ability to bridge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-like structure. | Single-molecule observation of DNA compaction by meiotic protein SYCP3.
Syrjänen JL, Heller I, Candelli A, Davies OR, Peterman EJ, Wuite GJ, Pellegrini L., Free PMC Article | 02/10/2018 |
| SYCP3 binds to RAD51 and attenuates RAD51 activity during meiosis. | SYCP3 regulates strand invasion activities of RAD51 and DMC1.
Kobayashi W, Hosoya N, Machida S, Miyagawa K, Kurumizaka H. | 01/13/2018 |
| SYCP3 binding and assembly on meiotic chromosomes leads to their organisation into compact structures compatible with recombination and crossover formation | A molecular model for the role of SYCP3 in meiotic chromosome organisation.
Syrjänen JL, Pellegrini L, Davies OR., Free PMC Article | 08/1/2015 |
| The T657C polymorphism of the SYCP3 gene is possibly associated with recurrent pregnancy loss of unknown cause in human. | The T657C polymorphism on the SYCP3 gene is associated with recurrent pregnancy loss.
Sazegari A, Kalantar SM, Pashaiefar H, Mohtaram S, Honarvar N, Feizollahi Z, Ghasemi N., Free PMC Article | 06/20/2015 |
| SCP3 plays an important role in the progression of cervical cancer | Synaptonemal complex protein 3 is a prognostic marker in cervical cancer.
Cho H, Noh KH, Chung JY, Takikita M, Chung EJ, Kim BW, Hewitt SM, Kim TW, Kim JH., Free PMC Article | 01/31/2015 |
| SYCP3 mutations are not associated with the genetic susceptibility for meiotic arrest in infertile male patients with nonobstructive azoospermia in the Turkish population | Investigation of mutations in the synaptonemal complex protein 3 (SYCP3) gene among azoospermic infertile male patients in the Turkish population.
Gurkan H, Aydin F, Kadıoglu A, Palanduz S. | 09/7/2013 |
| screening for genetic variants in AURKB and SYCP3 among these patients with reproductive problems using Sanger sequencing. Only one apparently non-pathogenic deletion was found in SYCP3. | Mutation screening of AURKB and SYCP3 in patients with reproductive problems.
López-Carrasco A, Oltra S, Monfort S, Mayo S, Roselló M, Martínez F, Orellana C. | 06/29/2013 |
| Positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival. | Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer.
Chung JY, Kitano H, Takikita M, Cho H, Noh KH, Kim TW, Ylaya K, Hanaoka J, Fukuoka J, Hewitt SM., Free PMC Article | 05/11/2013 |
| mutations in SYCP3 do not contribute significantly to risk for recurrent miscarriage through maternal meiotic nondisjunction. | Absence of SYCP3 mutations in women with recurrent miscarriage with at least one trisomic miscarriage.
Hanna CW, Blair JD, Stephenson MD, Robinson WP. | 06/2/2012 |
| Expression of SYCP3 inhibits the homologous recombination (HR) pathway mediated by RAD51. | Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.
Hosoya N, Okajima M, Kinomura A, Fujii Y, Hiyama T, Sun J, Tashiro S, Miyagawa K., Free PMC Article | 04/28/2012 |
| The 657T>C mutation of SYCP3 may not be associated with recurrent miscarriage caused by aneuploidy. | SYCP3 mutation may not be associated with recurrent miscarriage caused by aneuploidy.
Mizutani E, Suzumori N, Ozaki Y, Oseto K, Yamada-Namikawa C, Nakanishi M, Sugiura-Ogasawara M. | 08/13/2011 |
| mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages; heterozygous change, detected in a conserved functional domain of the SYCP3 gene, was absent in >200 controls | Mutation analysis of three genes in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.
Stouffs K, Vandermaelen D, Tournaye H, Liebaers I, Lissens W. | 05/7/2011 |
| X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity | Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity.
Kang TH, Noh KH, Kim JH, Bae HC, Lin KY, Monie A, Pai SI, Hung CF, Wu TC, Kim TW., Free PMC Article | 05/3/2010 |
| mutations in SYPR3 are likely to generate an aberrant synaptonemal complex in a dominant-negative manner and contribute to abnormal chromosomal behavior that might lead to recurrent miscarriage. | Mutations of the SYCP3 gene in women with recurrent pregnancy loss.
Bolor H, Mori T, Nishiyama S, Ito Y, Hosoba E, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Kato T, Tong M, Nishizawa H, Pryor-Koishi K, Kitaoka E, Sawada T, Nishiyama Y, Udagawa Y, Kurahashi H, Bolor H, Mori T, Nishiyama S, Ito Y, Hosoba E, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Kato T, Tong M, Nishizawa H, Pryor-Koishi K, Kitaoka E, Sawada T, Nishiyama Y, Udagawa Y, Kurahashi H., Free PMC Articles: PMC2668043, PMC2668043 | 01/21/2010 |
| These observations suggest that SCP3 is expressed in adult human and monkey ovaries. | Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries.
Bukovsky A, Caudle MR, Gupta SK, Svetlikova M, Selleck-White R, Ayala AM, Dominguez R. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesMutations of the SYCP3 gene in women with recurrent pregnancy loss.
Bolor H, Mori T, Nishiyama S, Ito Y, Hosoba E, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Kato T, Tong M, Nishizawa H, Pryor-Koishi K, Kitaoka E, Sawada T, Nishiyama Y, Udagawa Y, Kurahashi H, Bolor H, Mori T, Nishiyama S, Ito Y, Hosoba E, Inagaki H, Kogo H, Ohye T, Tsutsumi M, Kato T, Tong M, Nishizawa H, Pryor-Koishi K, Kitaoka E, Sawada T, Nishiyama Y, Udagawa Y, Kurahashi H. Azoospermia in patients heterozygous for a mutation in SYCP3.
Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ, Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ. | 03/13/2008 |
| No functional SYCP3 exonic SNP was found in infertile Spanish patients with meiosis arrest, suggesting that SYCP3 mutations very likely are not relevant in Spain in genetic susceptibility to meiosis arrest. | Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest.
Martínez J, Bonache S, Carvajal A, Bassas L, Larriba S. | 01/21/2010 |
| SYCP3 is expressed in human testis and is restricted to germ cells. Lack of SYCP3 expression in human testis may have a negative effect on spermatogenesis and male fertility. | Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia.
Aarabi M, Modarressi MH, Soltanghoraee H, Behjati R, Amirjannati N, Akhondi MM. | 01/21/2010 |
| We suggest that SYCP3 has an essential meiotic function in human spermatogenesis that is compromised by the mutant protein via dominant negative interference. | Azoospermia in patients heterozygous for a mutation in SYCP3.
Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ, Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ. | 01/21/2010 |
| In contrast to previously reported high frequency of SYCP3 mutations in patients with azoospermia, only polymorphisms are found in the present study | SYCP3 mutations are uncommon in patients with azoospermia.
Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I. | 01/21/2010 |