| TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway. | TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway.
Man J, Zhou W, Zuo S, Zhao X, Wang Q, Ma H, Li HY. | 06/25/2023 |
| Refolding and purification of cGMP-grade recombinant human neurturin from Escherichia coli inclusion bodies. | Refolding and purification of cGMP-grade recombinant human neurturin from Escherichia coli inclusion bodies.
Xi G, Esfandiary R, Sacramento CB, Jouihan H, Sharma A, Roth R, Linke T. | 01/9/2021 |
| We have reconstituted the complete extracellular region of the RET signaling complex together with Neurturin (NRTN) and GFRalpha2 and determined its structure at 5.7-A resolution by cryo-EM. The proteins form an assembly through RET-GFRalpha2 and RET-NRTN interfaces. | Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.
Bigalke JM, Aibara S, Roth R, Dahl G, Gordon E, Dorbéus S, Amunts A, Sandmark J., Free PMC Article | 05/2/2020 |
| biophysical results show that the relative concentration of GFRa2 on cell surfaces can affect the functional affinity of NRTN through avidity effects. | Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.
Sandmark J, Dahl G, Öster L, Xu B, Johansson P, Akerud T, Aagaard A, Davidsson P, Bigalke JM, Winzell MS, Rainey GJ, Roth RG., Free PMC Article | 12/22/2018 |
| In the cochlea, NTN immunostaining was found in the supporting cells of organ of Corti, including Deiters' cells, Hensen cells as well as Claudius' cells. In the spiral ganglia, NTN was seen in both the cell bodies and the nerve fibers of neurons. | Immunohistological analysis of neurturin and its receptors in human cochlea.
Liu W, Rask-Andersen H. | 10/25/2014 |
| Neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer. | The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer.
Wang K, Demir IE, D'Haese JG, Tieftrunk E, Kujundzic K, Schorn S, Xing B, Kehl T, Friess H, Ceyhan GO. | 04/5/2014 |
| Human neurturin protected crayfish neurons and glia from photodynamic injury. | Protection effect of GDNF and neurturin on photosensitized crayfish neurons and glial cells.
Uzdensky A, Komandirov M, Fedorenko G, Lobanov A. | 07/27/2013 |
| Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms. | Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms.
Wan G, Zhou L, Lim Q', Wong YH, Too HP. | 12/31/2011 |
| No differences were found in the allelic frequencies of the variants or in the haplotype distribution between Hirschsprung's disease patients & controls, nor to any demographic/clinical parameters within the group of patients. | Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease.
Fernandez RM, Ruiz-Ferrer M, Lopez-Alonso M, Antiñolo G, Borrego S, Fernandez RM, Ruiz-Ferrer M, Lopez-Alonso M, Antiñolo G, Borrego S. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease.
Fernandez RM, Ruiz-Ferrer M, Lopez-Alonso M, Antiñolo G, Borrego S, Fernandez RM, Ruiz-Ferrer M, Lopez-Alonso M, Antiñolo G, Borrego S. | 11/16/2008 |
| GDNF, NTN, GFRalpha-1, GFRalpha-2, and c-Ret proteins are differentially expressed in the different stages of hair follicle cycle. GFRalpha-mediated signaling involves c-Ret and may play a role in human HF biology. | Expression patterns of the glial cell line-derived neurotrophic factor, neurturin, their cognate receptors GFRalpha-1, GFRalpha-2, and a common signal transduction element c-Ret in the human skin hair follicles.
Adly MA, Assaf HA, Pertile P, Hussein MR, Paus R. | 01/21/2010 |
| GDNF and NRTN are new neuromodulators that regulate the development of the neuromuscular synapse | Regulation of neuromuscular synapse development by glial cell line-derived neurotrophic factor and neurturin.
Wang CY, Yang F, He XP, Je HS, Zhou JZ, Eckermann K, Kawamura D, Feng L, Shen L, Lu B. | 01/21/2010 |
| The results obtained suggest the involvement of NTN, PSP, and ART in processes subserving both the organization of this cortical region during development and the functional activity and maintenance of the mature human hippocampal neurons. | Neurturin, persephin, and artemin in the human pre- and full-term newborn and adult hippocampus and fascia dentata.
Quartu M, Serra MP, Manca A, Mascia F, Follesa P, Del Fiacco M. | 01/21/2010 |
| Addition of neurturin to activated peripheral blood mononuclear leukocytes reduces the amount of detectable tumor necrosis factor protein without altering its transcription. | Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells.
Vargas-Leal V, Bruno R, Derfuss T, Krumbholz M, Hohlfeld R, Meinl E. | 01/21/2010 |
| GDNF and NTN differentially regulate the expression of distinct miRNA precursors through the activation of mitogen-activated protein kinase | Glial cell-line derived neurotrophic factor and neurturin regulate the expressions of distinct miRNA precursors through the activation of GFRalpha2.
Yoong LF, Wan G, Too HP. | 01/21/2010 |
| Depending on the brain's expressions of specific GDNF family GFRalpha2 receptor spliced isoforms, neurturin may promote or inhibit neurite outgrowth through the multicomponent receptor complex. | Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2.
Yoong LF, Too HP., Free PMC Article | 01/21/2010 |
| The gene expression of protein was studied in the developing human tooth. | Expression patterns of neurotrophic factor mRNAs in developing human teeth.
Nosrat I, Seiger A, Olson L, Nosrat CA. | 01/21/2010 |