| Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection. | Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection.
Sheng Y, Wu L, Chang Y, Liu W, Tao M, Chen X, Zhang X, Li B, Zhang N, Ye D, Zhang C, Zhu D, Zhao H, Chen A, Chen H, Song J., Free PMC Article | 10/30/2023 |
| Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis. | Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis.
Lee C, Xin G, Li F, Wan C, Yu X, Feng L, Wen A, Cao Y, Huang W., Free PMC Article | 08/19/2023 |
| Structural basis of NINJ1-mediated plasma membrane rupture in cell death. | Structural basis of NINJ1-mediated plasma membrane rupture in cell death.
Degen M, Santos JC, Pluhackova K, Cebrero G, Ramos S, Jankevicius G, Hartenian E, Guillerm U, Mari SA, Kohl B, Müller DJ, Schanda P, Maier T, Perez C, Sieben C, Broz P, Hiller S., Free PMC Article | 07/6/2023 |
| NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation. | NINJ1 Regulates Platelet Activation and PANoptosis in Septic Disseminated Intravascular Coagulation.
Zhou X, Yu X, Wan C, Li F, Wang Y, Zhang K, Feng L, Wen A, Deng J, Li S, Xin G, Huang W., Free PMC Article | 02/28/2023 |
| Lower expression of NINJ1 (Ninjurin 1), a mediator of plasma membrane rupture, is associated with advanced disease and worse prognosis in serous ovarian cancer. | Lower expression of NINJ1 (Ninjurin 1), a mediator of plasma membrane rupture, is associated with advanced disease and worse prognosis in serous ovarian cancer.
Berkel C, Cacan E. | 01/28/2023 |
| Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death. | Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Borges JP, Sætra RSR, Volchuk A, Bugge M, Devant P, Sporsheim B, Kilburn BR, Evavold CL, Kagan JC, Goldenberg NM, Flo TH, Steinberg BE., Free PMC Article | 01/14/2023 |
| NINJ1 triggers extravillous trophoblast cell dysfunction through blocking the STAT3 signaling pathway. | NINJ1 triggers extravillous trophoblast cell dysfunction through blocking the STAT3 signaling pathway.
Zhang X, Chen Y, Wang X, Zhang Z, Wang J, Shen Y, Hu Y, Wu X. | 10/22/2022 |
| Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/beta-Catenin signaling through Frizzled2-LRP6 assembly. | Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/β-Catenin signaling through Frizzled2-LRP6 assembly.
Hyun SY, Min HY, Lee HJ, Cho J, Boo HJ, Noh M, Jang HJ, Lee HJ, Park CS, Park JS, Shin YK, Lee HY., Free PMC Article | 04/23/2022 |
| Elevated plasma Ninjurin-1 levels in atrial fibrillation is associated with atrial remodeling and thromboembolic risk. | Elevated plasma Ninjurin-1 levels in atrial fibrillation is associated with atrial remodeling and thromboembolic risk.
Fang C, Jiao K, Zuo K, Yang X., Free PMC Article | 04/23/2022 |
| NINJ1 mediates plasma membrane rupture during lytic cell death. | NINJ1 mediates plasma membrane rupture during lytic cell death.
Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, Li Q, Sandoval W, Yan D, Kang J, Xu M, Zhang J, Lee WP, McKenzie BS, Ulas G, Payandeh J, Roose-Girma M, Modrusan Z, Reja R, Sagolla M, Webster JD, Cho V, Andrews TD, Morris LX, Miosge LA, Goodnow CC, Bertram EM, Dixit VM. | 07/24/2021 |
| Radiation Potentiates Monocyte Infiltration into Tumors by Ninjurin1 Expression in Endothelial Cells. | Radiation Potentiates Monocyte Infiltration into Tumors by Ninjurin1 Expression in Endothelial Cells.
Kang JH, Woo JK, Jang YS, Oh SH., Free PMC Article | 03/6/2021 |
| Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance. | Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance.
Choi H, Bae SJ, Choi G, Lee H, Son T, Kim JG, An S, Lee HS, Seo JH, Kwon HB, Jeon S, Oh GT, Surh YJ, Kim KW. | 01/16/2021 |
| Our study demonstrates that Ninj1 is expressed in endometriosis and adenomyosis and is induced by the inflammatory stimuli | Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis.
Miyashita M, Koga K, Takeuchi A, Makabe T, Taguchi A, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Yoshino O, Fujii T, Osuga Y. | 04/4/2020 |
| We analyzed cardiac biopsies from aortic-stenosis patients and control patients undergoing elective heart surgery..We conclude that Ninjurin1 contributes to myocyte growth and differentiation, and that these effects are mainly mediated by N-glycosylated Ninjurin1-24. | Ninjurin1 regulates striated muscle growth and differentiation.
Kny M, Csályi KD, Klaeske K, Busch K, Meyer AM, Merks AM, Darm K, Dworatzek E, Fliegner D, Baczko I, Regitz-Zagrosek V, Butter C, Luft FC, Panáková D, Fielitz J., Free PMC Article | 01/25/2020 |
| Data show that Ninj1 assembles into a homomeric protein complex and that N-glycosylation is a prerequisite for Ninj1 homomer assembly. | Ninjurin1 Assembles Into a Homomeric Protein Complex Maintained by N-linked Glycosylation.
Bae SJ, Shin MW, Kim RH, Shin D, Son T, Wee HJ, Kim KW. | 12/30/2017 |
| Ninj1 suppresses migration, invasion and metastasis of lung cancer via inhibition of the IL-6 signaling pathway in vitro and in vivo. | Ninjurin1 suppresses metastatic property of lung cancer cells through inhibition of interleukin 6 signaling pathway.
Jang YS, Kang JH, Woo JK, Kim HM, Hwang JI, Lee SJ, Lee HY, Oh SH. | 04/29/2017 |
| High ninjurin 1 expression is associated with Prostate Cancer. | Ninjurin1 Is Up-regulated in Circulating Prostate Tumor Cells and Plays a Critical Role in Prostate Cancer Cell Motility.
Park J, Joung JY, Hwang JE, Hong D, Park WS, Lee SJ, Lee KH. | 04/15/2017 |
| Ninj1 expression was detected in both HSMCs and HUVECs, and was higher in the former. Ninj1 expression was enhanced by hypoxia in HUVECs. | Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes.
Matsuki M, Kabara M, Saito Y, Shimamura K, Minoshima A, Nishimura M, Aonuma T, Takehara N, Hasebe N, Kawabe J. | 03/5/2016 |
| Ninj1 modulates TLR4 signaling, which itself plays a major role in systemic inflammatory response syndrome and sepsis. | Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation.
Jennewein C, Sowa R, Faber AC, Dildey M, von Knethen A, Meybohm P, Scheller B, Dröse S, Zacharowski K. | 02/6/2016 |
| The NINJ1 gene polymorphism plays an important role in nerve degeneration in leprosy patients. | NINJURIN1 single nucleotide polymorphism and nerve damage in leprosy.
Graça CR, Paschoal VD, Cordeiro-Soubhia RM, Tonelli-Nardi SM, Machado RL, Kouyoumdjian JA, Baptista Rossit AR. | 07/21/2012 |
| Data show an important cell-specific role for Ninjurin-1 in the transmigration of inflammatory APCs across the BBB. | Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions.
Ifergan I, Kebir H, Terouz S, Alvarez JI, Lécuyer MA, Gendron S, Bourbonnière L, Dunay IR, Bouthillier A, Moumdjian R, Fontana A, Haqqani A, Klopstein A, Prinz M, López-Vales R, Birchler T, Prat A. | 02/11/2012 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q., Free PMC Article | 04/7/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGenetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. DNA polymorphisms as tools for spinal cord injury research.
Guimarães PE, Fridman C, Gregório SP, Kalil EM, Cristante AF, Teixeira WG, Rodrigues CJ, Costa MC, Gattaz WF, Barros TE, Oliveira PS, Dias-Neto E. | 06/4/2008 |
| Our data suggests that Ninjurin 1 asp110ala SNP could be a valuable genetic marker of nerve damage in leprosy. | Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage.
Cardoso CC, Martinez AN, Guimarães PE, Mendes CT, Pacheco AG, de Oliveira RB, Teles RM, Illarramendi X, Sampaio EP, Sarno EN, Dias-Neto E, Moraes MO. | 01/21/2010 |
| Ninjurin1 is able to induce the senescence program. Ninjurin1 may be involved in the regulation of cellular senescence in the liver during carcinogenesis. | Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells.
Toyama T, Sasaki Y, Horimoto M, Iyoda K, Yakushijin T, Ohkawa K, Takehara T, Kasahara A, Araki T, Hori M, Hayashi N. | 01/21/2010 |