| HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells. | HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells.
Wang H, Shi Y, Zhou X, Zhang L, Yang A, Zhou D, Ma T., Free PMC Article | 06/25/2024 |
| CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability. | CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability.
Yang F, Ma Q, Huang B, Wang X, Pan X, Yu T, Ran L, Jiang S, Li H, Chen Y, Liu Y, Liang C, Ren J, Zhang Y, Wang S, Li W, Xiao B., Free PMC Article | 06/28/2023 |
| lncRNA NEAT1 promotes hypoxia-induced inflammation and fibrosis of alveolar epithelial cells via targeting miR-29a/NFATc3 axis. | lncRNA NEAT1 promotes hypoxia-induced inflammation and fibrosis of alveolar epithelial cells via targeting miR-29a/NFATc3 axis.
Zhang X, Duan XJ, Li LR, Chen YP. | 08/27/2022 |
| Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression. | Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression.
Tong Y, Zhang Z, Cheng Y, Yang J, Fan C, Zhang X, Yang J, Wang L, Guo D, Yan D., Free PMC Article | 05/7/2022 |
| Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms. | Macrophage NFATc3 prevents foam cell formation and atherosclerosis: evidence and mechanisms.
Liu X, Guo JW, Lin XC, Tuo YH, Peng WL, He SY, Li ZQ, Ye YC, Yu J, Zhang FR, Ma MM, Shang JY, Lv XF, Zhou AD, Ouyang Y, Wang C, Pang RP, Sun JX, Ou JS, Zhou JG, Liang SJ. | 12/25/2021 |
| Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression. | Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression.
Da J, Wang X, Li L, Xu Y. | 11/13/2021 |
| Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition. | Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition.
Lin Y, Koumba MH, Qu S, Wang D, Lin L. | 10/23/2021 |
| circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression. | circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression.
Jia C, Yao Z, Lin Z, Zhao L, Cai X, Chen S, Deng M, Zhang Q. | 09/11/2021 |
| NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription. | NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription.
Zao X, Cheng J, Shen C, Guan G, Feng X, Zou J, Zhang J, Liu T, Zheng H, Zhang T, Wang J, Liu J, Li D, Lu F, You F, Chen X., Free PMC Article | 08/7/2021 |
| data indicated that NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation. | LncRNA NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation.
Wang Y, Xu P, Zhang C, Feng J, Gong W, Ge S, Guo Z. | 07/20/2019 |
| Expression of the NFATC3-PLA2G15 chimera correlated with aggressive disease biology in murine patient-derived T-ALL xenografts, and poor prognosis in human T-ALL patients. | Novel Intergenically Spliced Chimera, NFATC3-PLA2G15, Is Associated with Aggressive T-ALL Biology and Outcome.
Bond J, Tran Quang C, Hypolite G, Belhocine M, Bergon A, Cordonnier G, Ghysdael J, Macintyre E, Boissel N, Spicuglia S, Asnafi V. | 02/9/2019 |
| MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRA | MicroRNA-214 regulates immunity-related genes in bovine mammary epithelial cells by targeting NFATc3 and TRAF3.
Song N, Wang X, Gui L, Raza SHA, Luoreng Z, Zan L. | 05/26/2018 |
| The NFATc3 first induced the expression of its interaction partner FosB before forming the heterodimeric NFATc3-FosB transcription factor complex, which bound the proximal AP-1 site in the TF gene promoter and activated TF expression. | Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking.
Kotla S, Singh NK, Kirchhofer D, Rao GN., Free PMC Article | 09/30/2017 |
| NFAT1 is stimulated by subplasmalemmal Ca2+ microdomains, whereas NFAT4 additionally requires Ca2+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors. | Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca(2+) Signals.
Kar P, Mirams GR, Christian HC, Parekh AB., Free PMC Article | 09/2/2017 |
| we found that VIP inhibits NFAT nuclear translocation in primary human pulmonary artery smooth muscle cells (PASMC). Early activation of NFATc3 in IPF patients may contribute to disease progression and the increase in VIP expression could be a protective compensatory mechanism | NFATc3 and VIP in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease.
Szema AM, Forsyth E, Ying B, Hamidi SA, Chen JJ, Hwang S, Li JC, Sabatini Dwyer D, Ramiro-Diaz JM, Giermakowska W, Gonzalez Bosc LV., Free PMC Article | 08/19/2017 |
| the transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells. | NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells.
Bao M, Wang Y, Liu Y, Shi P, Lu H, Sha W, Weng L, Hanabuchi S, Qin J, Plumas J, Chaperot L, Zhang Z, Liu YJ., Free PMC Article | 08/5/2017 |
| Calcineurin together with its upstream molecule, calpain 2, and its downstream effector, NFAT-c3, might contribute to the development of atrial fibrillation in patients with heart valve disease and diabetes. | Calpain-Calcineurin-Nuclear Factor Signaling and the Development of Atrial Fibrillation in Patients with Valvular Heart Disease and Diabetes.
Zhao Y, Cui GM, Zhou NN, Li C, Zhang Q, Sun H, Han B, Zou CW, Wang LJ, Li XD, Wang JC., Free PMC Article | 12/17/2016 |
| two NFAT isoforms (NFAT4 and NFAT1) have shifted band-pass windows for the same receptor in the GPCR signaling pathway | Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation.
Sumit M, Neubig RR, Takayama S, Linderman JJ., Free PMC Article | 09/17/2016 |
| Data indicate that RNA interference of NFAT isoforms NFATc1, NFATc2, NFATc3 and NFATc4 regulate gene expression differentially in human retinal microvascular endothelial cells (HRMEC). | NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.
Bretz CA, Savage SR, Capozzi ME, Suarez S, Penn JS., Free PMC Article | 09/10/2016 |
| NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis | Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.
Mojsa B, Mora S, Bossowski JP, Lassot I, Desagher S., Free PMC Article | 08/8/2015 |
| Results show that two protein isoforms NFAT1 and NFAT4 are both cytosolic and stimulated by the same Ca2+ messenger but require distinct subcellular Ca2+ signals for activity. | Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms.
Kar P, Parekh AB., Free PMC Article | 07/4/2015 |
| Suggest nuclear NF-AT3 and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-beta1 levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation. | Increased expression of NF-AT3 and NF-AT4 in the atria correlates with procollagen I carboxyl terminal peptide and TGF-β1 levels in serum of patients with atrial fibrillation.
Zhao F, Zhang S, Chen Y, Gu W, Ni B, Shao Y, Wu Y, Qin J., Free PMC Article | 05/23/2015 |
| Microvesicles from tumor cells transferred TrpC5 to endothelial cells, inducing the expression of P-glycoprotein by activation of the transcription factor NFATc3 (nuclear factor of activated T cells isoform c3). | Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells.
Dong Y, Pan Q, Jiang L, Chen Z, Zhang F, Liu Y, Xing H, Shi M, Li J, Li X, Zhu Y, Chen Y, Bruce IC, Jin J, Ma X. | 06/14/2014 |
| AP-1 and NFAT4 complex promotes miR-23a expression. | miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer.
Zheng H, Li W, Wang Y, Xie T, Cai Y, Wang Z, Jiang B. | 04/5/2014 |
| The closely related transcription factors NFAT1 and NFAT4 possess distinct nuclear localization dynamics in response to cell stimulation. | Dynamic response diversity of NFAT isoforms in individual living cells.
Yissachar N, Sharar Fischler T, Cohen AA, Reich-Zeliger S, Russ D, Shifrut E, Porat Z, Friedman N. | 03/30/2013 |