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    MSX1 msh homeobox 1 [ Homo sapiens (human) ]

    Gene ID: 4487, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Orodental malformations associated with human MSX1 sequence variants.

    Orodental malformations associated with human MSX1 sequence variants.
    Wang YL, Chu KY, Hsieh TF, Yao CJ, Lin CH, Lee ZH, Wang SK.

    06/13/2024
    Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus.

    Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus.
    Shen Z, Zhang S, Gao Z, Yu X, Wang J, Pan S, Kang N, Liu N, Xu H, Liu M, Yang Y, Deng Q, Liu J, Xie Y, Zhang J., Free PMC Article

    02/22/2024
    Characterization of novel MSX1 variants causally associated with non-syndromic oligodontia in Chinese families.

    Characterization of novel MSX1 variants causally associated with non-syndromic oligodontia in Chinese families.
    Zhao Y, Ren J, Meng L, Hou Y, Liu C, Zhang G, Shen W., Free PMC Article

    02/5/2024
    MSX1 involved selective tooth agenesis and abnormal labial frenum, pedigree, and retrospective study.

    MSX1 involved selective tooth agenesis and abnormal labial frenum, pedigree, and retrospective study.
    Zhu Y, Zhang Y, Dong J, Ruan W, Yang S, Huang P, Duan X.

    12/15/2023
    MSX1-expression during the different phases in healthy human endometrium.

    MSX1-expression during the different phases in healthy human endometrium.
    Eppich S, Kuhn C, Schmoeckel E, Mayr D, Mahner S, Jeschke U, Gallwas J, Heidegger HH., Free PMC Article

    05/26/2023
    LINC01021 maintains tumorigenicity by enhancing N6-methyladenosine reader IMP2 dependent stabilization of MSX1 and JARID2: implication in colorectal cancer.

    LINC01021 maintains tumorigenicity by enhancing N6-methyladenosine reader IMP2 dependent stabilization of MSX1 and JARID2: implication in colorectal cancer.
    Wu H, Ding X, Hu X, Zhao Q, Chen Q, Sun T, Li Y, Guo H, Li M, Gao Z, Yao W, Zhao L, Li K, Wei M.

    04/23/2022
    Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer.

    Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer.
    Lee Y, Dho SH, Lee J, Hwang JH, Kim M, Choi WY, Lee JY, Lee J, Chang W, Lee MY, Choi J, Kim TY, Kim LK., Free PMC Article

    04/23/2022
    Family and case-control genetic study of MSX1 polymorphisms in peg-shaped teeth Jordanian population.

    Family and case-control genetic study of MSX1 polymorphisms in peg-shaped teeth Jordanian population.
    Alkhatib R, Hawamdeh R, Al-Eitan L, Abdo N, Obeidat F, Al-Bataineh M, Aman H., Free PMC Article

    03/26/2022
    IRF6, MSX1, TGFA, dental anomalies, and skeletal malocclusion.

    IRF6, MSX1, TGFA, dental anomalies, and skeletal malocclusion.
    Fernandez CCA, Pereira CVCA, Ferreira FFCF, Maciel JVB, Modesto A, Costa MC, Vieira AR.

    10/9/2021
    Association of Polymorphic and Haplotype Variants of the MSX1 Gene and the Impacted Teeth Phenomenon.

    Association of Polymorphic and Haplotype Variants of the MSX1 Gene and the Impacted Teeth Phenomenon.
    Trybek G, Jaroń A, Grzywacz A., Free PMC Article

    08/14/2021
    Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis.

    Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis.
    Son MJ, Rho SB, Kim K, Oh M, Son C, Song SY, Park K., Free PMC Article

    03/28/2021
    MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.

    MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.
    Eppich S, Kuhn C, Schmoeckel E, Mayr D, Mahner S, Jeschke U, Gallwas J, Heidegger HH., Free PMC Article

    03/13/2021
    Novel MSX1 variants identified in families with nonsyndromic oligodontia.

    Novel MSX1 variants identified in families with nonsyndromic oligodontia.
    Zheng J, Yu M, Liu H, Cai T, Feng H, Liu Y, Han D., Free PMC Article

    02/20/2021
    A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma.

    A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma.
    Szemes M, Melegh Z, Bellamy J, Greenhough A, Kollareddy M, Catchpoole D, Malik K., Free PMC Article

    02/13/2021
    MSX1 is differentially expressed in the deepest impacted maxillary third molars.

    MSX1 is differentially expressed in the deepest impacted maxillary third molars.
    Olsson B, Calixto RD, da Silva Machado NC, Meger MN, Paula-Silva FWG, Rebellato NLB, da Costa DJ, Küchler EC, Scariot R.

    12/12/2020
    Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium.

    Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium.
    Horazna M, Janeckova L, Svec J, Babosova O, Hrckulak D, Vojtechova M, Galuskova K, Sloncova E, Kolar M, Strnad H, Korinek V., Free PMC Article

    09/19/2020
    Study of two unrelated Chinese individuals with non-syndromic tooth agenesis and their families identified two novel mutations: a missense mutation c.572 T>C and a frameshift mutation c.590_594 dup TGTCC, which were both detected in the homeodomain of MSX1.

    Two novel mutations in MSX1 causing oligodontia.
    Yang L, Liang J, Yue H, Bian Z., Free PMC Article

    05/9/2020
    the variant genotype of the MSX1 rs8670 SNP was the most frequent in frontal agenesis; meanwhile in the lateral agenesis nonsyndromic hypodontia (NSH)As far as PAX9 rs61754301 and rs4904155 SNPs are considered, our findings were not significant as it seems that these polymorphisms have no influen group, the AXIN2 rs2240308 SNP showed a higher frequency of the variant genotype, with a trend towards statistical significance

    Study of rs12532, rs8670 Polymorphism of Msh Homeobox 1 (MSX1), rs61754301, rs4904155 Polymorphism of Paired Box Gene 9 (PAX9), and rs2240308 Polymorphism of Axis Inhibitor Protein 2 (AXIN2) Genes in Nonsyndromic Hypodontia.
    Mártha K, Kerekes Máthé B, Moldovan VG, Bănescu C., Free PMC Article

    04/11/2020
    synonymous change in MSX1 (rs34165410) showed association with NSCL+/-P, which may create an alternative splice site or lead to low codon usage

    TGFβ3, MSX1, and MMP3 as Candidates for NSCL±P in an Indian Population.
    Kumari P, Singh SK, Raman R.

    01/18/2020
    lack of association of MSX1 rs12532 and the risk of nonsyndromic unilateral complete cleft lip and palate and tooth agenesis

    Association between MSX1 rs12532 polymorphism with nonsyndromic unilateral complete cleft lip and palate and tooth agenesis.
    Lancia M, Machado RA, Dionísio TJ, Garib DG, Santos CFD, Coletta RD, Neves LTD.

    01/11/2020
    results suggest that the rs12532 and rs2073247 polymorphisms of genes MSX1 and PAX9 are positively associated with palatal impaction of maxillary canines

    Role of polymorphisms of MSX1 and PAX9 genes in palatal impaction of maxillary canines.
    Devi MSA, Padmanabhan S.

    12/28/2019
    The Msx1 gene was widely expressed in mouse craniofacial structures from embryonic day (E)8.5-E10.5. Taken together, the study indicates that MSX1 rs12532 is associated with the risk of non-syndromic orofacial clefts (NSOCs). [review]

    MSH homeobox 1 polymorphisms and the risk of non-syndromic orofacial clefts: a meta-analysis.
    Gu M, Zhang Y, Liu H, Liu J, Zhu D, Yang X.

    05/11/2019
    Study results suggest that the neural crest-like reprogramming process conferred by MSX1 contributes to the metastatic spread of melanoma.

    MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression.
    Heppt MV, Wang JX, Hristova DM, Wei Z, Li L, Evans B, Beqiri M, Zaman S, Zhang J, Irmler M, Berking C, Besch R, Beckers J, Rauscher FJ 3rd, Sturm RA, Fisher DE, Herlyn M, Fukunaga-Kalabis M., Free PMC Article

    03/30/2019
    A novel mutation of MSX1 in oligodontia found in a Chinese pedigree inhibits odontogenesis of dental pulp stem cells via the ERK pathway.

    A novel mutation of MSX1 in oligodontia inhibits odontogenesis of dental pulp stem cells via the ERK pathway.
    Xin T, Zhang T, Li Q, Yu T, Zhu Y, Yang R, Zhou Y., Free PMC Article

    03/16/2019
    germline variant in MSX1 was identified in a Dutch family with clustering of Barrett's esophagus and esophageal adenocarcinoma

    Germline variant in MSX1 identified in a Dutch family with clustering of Barrett's esophagus and esophageal adenocarcinoma.
    van Nistelrooij AMJ, van Marion R, van Ijcken WFJ, de Klein A, Wagner A, Biermann K, Spaander MCW, van Lanschot JJB, Dinjens WNM, Wijnhoven BPL., Free PMC Article

    03/9/2019
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