| GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression. | GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression.
Xi X, Yang Y, Chen Q, Ma J, Wang X, Deng Y, Wang X, Li Y., Free PMC Article | 03/20/2024 |
| Aberrant N-glycosylation in cancer: MGAT5 and beta1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression. | Aberrant N-glycosylation in cancer: MGAT5 and β1,6-GlcNAc branched N-glycans as critical regulators of tumor development and progression.
de-Souza-Ferreira M, Ferreira ÉE, de-Freitas-Junior JCM. | 05/25/2023 |
| N-acetylglucosaminyltransferase-V requires a specific noncatalytic luminal domain for its activity toward glycoprotein substrates. | N-acetylglucosaminyltransferase-V requires a specific noncatalytic luminal domain for its activity toward glycoprotein substrates.
Osuka RF, Hirata T, Nagae M, Nakano M, Shibata H, Okamoto R, Kizuka Y., Free PMC Article | 04/30/2022 |
| Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing. | Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing.
Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D, Bakalara N., Free PMC Article | 11/27/2021 |
| The polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people. | The polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people.
Li X, Zhou G, Tian X, Chen F, Li G, Ding Y., Free PMC Article | 11/6/2021 |
| Nglycosylation and receptor tyrosine kinase signaling affect claudin3 levels in colorectal cancer cells. | N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.
Pérez AG, Andrade-Da-Costa J, De Souza WF, De Souza Ferreira M, Boroni M, De Oliveira IM, Freire-Neto CA, Fernandes PV, De Lanna CA, Souza-Santos PT, Morgado-Díaz JA, De-Freitas-Junior JCM., Free PMC Article | 07/10/2021 |
| Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis. | Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulation of T Cells Glycosylation and Plasma IgG Glycome Composition in Ulcerative Colitis.
Pereira MS, Durães C, Catarino TA, Costa JL, Cleynen I, Novokmet M, Krištić J, Štambuk J, Conceição-Neto N, Machado JC, Marcos-Pinto R, Magro F, Vermeire S, Lauc G, Lago P, Pinho SS., Free PMC Article | 05/15/2021 |
| Recognition of glycan and protein substrates by N-acetylglucosaminyltransferase-V. | Recognition of glycan and protein substrates by N-acetylglucosaminyltransferase-V.
Hirata T, Nagae M, Osuka RF, Mishra SK, Yamada M, Kizuka Y. | 01/9/2021 |
| Results suggest increased post-translational modification of RPTPmu N-glycans by GnT-V attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCgamma-PKC pathways. | β1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCγ-PKC pathways.
Gao Y, Yang F, Su Z, He Z, Xiao J, Xu Y, Zha X, Xu F, Wang L. | 05/11/2019 |
| GnT-V enhances gemcitabine chemosensitivity via modulation of human ENT1 N-glycosylation and transport activity in T24cells, providing new insights into how N-glycosylation drives antitumor drug sensitivity during chemotherapy for patients with cancer. | GnT-V promotes chemosensitivity to gemcitabine in bladder cancer cells through β1,6 GlcNAc branch modification of human equilibrative nucleoside transporter 1.
Tang Y, Cong X, Wang S, Fang S, Dong X, Yuan Y, Fan J. | 01/19/2019 |
| The acceptor-GnT-V complex structure suggests a catalytic mechanism, explains the previously observed inhibition of GnT-V by branching enzyme GnT-III, and provides a basis for the rational design of drugs targeting N-glycan branching. | Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V.
Nagae M, Kizuka Y, Mihara E, Kitago Y, Hanashima S, Ito Y, Takagi J, Taniguchi N, Yamaguchi Y., Free PMC Article | 01/19/2019 |
| The best homology model is consistent with available experimental data. The three-dimensional model, the structure of the enzyme catalytic site and binding information obtained for the donor and acceptor can be useful in studies of the catalytic mechanism and design of inhibitors of GnT-V. | Three-dimensional homology model of GlcNAc-TV glycosyltransferase.
Janoš P, Kozmon S, Tvaroška I, Koca J. | 01/20/2018 |
| Our data suggest that oxidative stress induces the overexpression of MGAT5 via the regulation of the focal adhesion kinase-extracellular signal-regulated kinase signaling pathway, which, in turn, affects the function of endothelial cells, which then participates in the pathogenesis of preeclampsia. | The Role of MGAT5 in Human Umbilical Vein Endothelial Cells.
Deng Q, Chen Y, Yin N, Shan N, Luo X, Yuan Y, Luo X, Liu Y, Liu X, Qi H. | 11/4/2017 |
| PTPalpha is identified as a novel substrate of N-Acetylglucosaminyltransferase V (GnT-V) and could be a factor regulating promotion of migration in breast cancer cells | β1,6 GlcNAc branches-modified protein tyrosine phosphatase alpha enhances its stability and promotes focal adhesion formation in MCF-7 cells.
Xiao J, Gao Y, Yang F, Wang C, Xu Y, Chang R, Zha X, Wang L. | 06/10/2017 |
| Tunicamycin, an inhibitor of N-glycan biosynthesis, was also able to enhance the radiosensitivity of U251 cells. Thus, our results suggest that development of therapeutic approaches targeting N-linked beta1,6-GlcNAc branches which are encoded by N-acetylglucosaminyltransferase V may be a promising strategy in glioblastoma treatment | Radiosensitisation of human glioma cells by inhibition of β1,6-GlcNAc branched N-glycans.
Shen L, Dong XX, Wu JB, Qiu L, Duan QW, Luo ZG. | 02/18/2017 |
| the knockdown of GnTV significantly suppressed the proliferation, migration and invasion (P<0.05) of the SMMC7721/R cells. | Effect of GnT-V knockdown on the proliferation, migration and invasion of the SMMC7721/R human hepatocellular carcinoma drug-resistant cell line.
Li B, Su S, Zhang MY, He L, Wang QD, He K. | 10/1/2016 |
| role in the inhibition of trophoblast cell invasion and migration during early pregnancy by direct or indirect regulation of MMP2/9 activity | N-acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy.
Deng Q, Chen Y, Yin N, Shan N, Luo X, Tong C, Zhang H, Baker PN, Liu X, Qi H. | 09/17/2016 |
| the level of TGFBR1 and early osteogenic differentiation were abolished in the DPSCs transfected with siRNA for GnT-V knockdown...GnT-V plays a critical role in the hexosamine-induced activation of TGF-b signaling and osteogenic differentiation | Hexosamine-Induced TGF-β Signaling and Osteogenic Differentiation of Dental Pulp Stem Cells Are Dependent on N-Acetylglucosaminyltransferase V.
Chen YJ, Yao CC, Huang CH, Chang HH, Young TH., Free PMC Article | 09/3/2016 |
| binding of recombinant Gal-3 to the RPE cell surface and inhibitory effects on RPE attachment and spreading largely dependent on interaction with Mgat5 modified N-glycans | Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased β1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding.
Priglinger CS, Obermann J, Szober CM, Merl-Pham J, Ohmayer U, Behler J, Gruhn F, Kreutzer TC, Wertheimer C, Geerlof A, Priglinger SG, Hauck SM., Free PMC Article | 07/16/2016 |
| Mgat5 plays an important role in early spontaneous miscarriage in humans. | Altered β1,6-GlcNAc and bisecting GlcNAc-branched N-glycan on integrin β1 are associated with early spontaneous miscarriage in humans.
Zhang M, Wang M, Gao R, Liu X, Chen X, Geng Y, Ding Y, Wang Y, He J. | 06/28/2016 |
| Gnt-V caused tumour growth more quickly | N-acetylglucosaminyltransferase V modulates radiosensitivity and migration of small cell lung cancer through epithelial-mesenchymal transition.
Huang C, Huang M, Chen W, Zhu W, Meng H, Guo L, Wei T, Zhang J. | 06/28/2016 |
| High expression of GnT-V was observed in infiltrating cells in skin section samples from systemic and localized patients with scleroderma. | Oligosaccharide modification by N-acetylglucosaminyltransferase-V in macrophages are involved in pathogenesis of bleomycin-induced scleroderma.
Kato A, Yutani M, Terao M, Kimura A, Itoi S, Murota H, Miyoshi E, Katayama I. | 05/21/2016 |
| MGAT5 protein and gene expression in in uveal and cutaneous melanoma cells | Diverse expression of N-acetylglucosaminyltransferase V and complex-type β1,6-branched N-glycans in uveal and cutaneous melanoma cells.
Pocheć E, Rydlewska M, Przybyło M, Lityńska A. | 04/30/2016 |
| UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats). | UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).
Maszczak-Seneczko D, Sosicka P, Kaczmarek B, Majkowski M, Luzarowski M, Olczak T, Olczak M., Free PMC Article | 02/27/2016 |
| Human Mgat5 increases amino acid uptake, intracellular levels of glycolytic and TCA intermediates, as well as HEK293 cell growth. | Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism.
Abdel Rahman AM, Ryczko M, Nakano M, Pawling J, Rodrigues T, Johswich A, Taniguchi N, Dennis JW., Free PMC Article | 09/26/2015 |