| Citrullination of myelin basic protein induces a Th17-cell response in healthy individuals and enhances the presentation of MBP85-99 in patients with multiple sclerosis. | Citrullination of myelin basic protein induces a Th17-cell response in healthy individuals and enhances the presentation of MBP85-99 in patients with multiple sclerosis.
Martín Monreal MT, Hansen BE, Iversen PF, Enevold C, Ødum N, Sellebjerg F, Højrup P, Rode von Essen M, Nielsen CH. | 08/25/2023 |
| Investigation of the relationship between MBP gene polymorphisms and delayed encephalopathy after acute carbon monoxide poisoning. | Investigation of the relationship between MBP gene polymorphisms and delayed encephalopathy after acute carbon monoxide poisoning.
Zhang F, Zeng J, Zhang X, Gu J, Han Y, Zhang P, Li W, Gu R. | 01/21/2023 |
| Multiple sclerosis and myelin basic protein: insights into protein disorder and disease. | Multiple sclerosis and myelin basic protein: insights into protein disorder and disease.
Martinsen V, Kursula P., Free PMC Article | 04/16/2022 |
| Multiple Sclerosis: Enzymatic Cross Site-Specific Hydrolysis of H1 Histone by IgGs against H1, H2A, H2B, H3, H4 Histones, and Myelin Basic Protein. | Multiple Sclerosis: Enzymatic Cross Site-Specific Hydrolysis of H1 Histone by IgGs against H1, H2A, H2B, H3, H4 Histones, and Myelin Basic Protein.
Nevinsky GA, Baranova SV, Buneva VN, Dmitrenok PS., Free PMC Article | 10/2/2021 |
| Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury. | Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury.
Bohnert S, Wirth C, Schmitz W, Trella S, Monoranu CM, Ondruschka B, Bohnert M., Free PMC Article | 09/25/2021 |
| HIV-Infected Patients: Cross Site-Specific Hydrolysis of H3 and H4 Histones and Myelin Basic Protein with Antibodies against These Three Proteins. | HIV-Infected Patients: Cross Site-Specific Hydrolysis of H3 and H4 Histones and Myelin Basic Protein with Antibodies against These Three Proteins.
Baranova SV, Dmitrenok PS, Buneva VN, Sedykh SE, Nevinsky GA., Free PMC Article | 09/11/2021 |
| HIV-Infected Patients: Cross Site-Specific Hydrolysis of H2a and H2b Histones and Myelin Basic Protein with Antibodies against These Three Proteins. | HIV-Infected Patients: Cross Site-Specific Hydrolysis of H2a and H2b Histones and Myelin Basic Protein with Antibodies against These Three Proteins.
Baranova SV, Dmitrienok PS, Buneva VN, Nevinsky GA., Free PMC Article | 06/26/2021 |
| A Polymorphism Within the MBP Gene Is Associated With a Higher Relapse Number in Male Patients of Multiple Sclerosis. | A Polymorphism Within the MBP Gene Is Associated With a Higher Relapse Number in Male Patients of Multiple Sclerosis.
Espino-Paisán L, Agudo-Jiménez T, Rosales-Martínez I, López-Cotarelo P, García-Martínez MÁ, Domínguez-Mozo MI, Pérez-Pérez S, Dieli-Crimi R, Comabella M, Urcelay E, Álvarez-Lafuente R., Free PMC Article | 04/3/2021 |
| The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide. | The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide.
Salutari I, Martin R, Caflisch A. | 11/21/2020 |
| results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals; there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power | Associations between Polymorphisms in the Solute Carrier Family 6 Member 3 and the Myelin Basic Protein Gene and Posttraumatic Stress Disorder.
Muminovic Umihanic M, Babic R, Kravic N, Avdibegovic E, Dzubur Kulenovic A, Agani F, Jakovljevic M, Babic D, Kucukalic A, Kucukalic S, Sabic Dzananovic E, Bravo Mehmedbasic A, Goci Uka A, Haxhibeqiri S, Hoxha B, Haxhibeqiri V, Aukst Margetic B, Jaksic N, Cima Franc A, Rudan D, Pavlović M, Feric Bojic E, Marjanovic D, Bozina N, Ziegler C, Wolf C, Warrings B, Domschke K, Deckert J, Sinanovic O. | 09/21/2019 |
| down-regulated in cord blood by prenatal smoking | Evidence of altered brain regulatory gene expression in tobacco-exposed fetuses.
Salihu HM, Paothong A, Das R, King LM, Pradhan A, Riggs B, Naik E, Siegel EM, Whiteman VE. | 07/21/2018 |
| the interaction between the HLA-DRB1*1501 allele and MBP gene may be considered as a predisposing factor in the development and pathogenesis of multiple sclerosis in the case of gene-gene interaction | Combination of Myelin Basic Protein Gene Polymorphisms with HLA-DRB1*1501 in Iranian Patients with Multiple Sclerosis.
Nejati P, Attar M, Rahimian M, Fathi D, Shahbazi M. | 05/12/2018 |
| PAPP-A and ProMBP are associated with increased risk of death in heart failure patients. | Pregnancy-associated plasma protein-A (PAPP-A) and the proform of the eosinophil major basic protein (ProMBP) are associated with increased risk of death in heart failure patients.
Dembic M, Hedley PL, Torp-Pedersen C, Køber L, Christiansen M. | 04/21/2018 |
| Studied potential use of myelin basic protein (MBP) as a biomarker in CSF of brain cancer patients. Results suggest that the presence of MBP in CSF may be considered as an indicator of the brain tumor development. | Is myelin basic protein a potential biomarker of brain cancer?
Zavialova MG, Shevchenko VE, Nikolaev EN, Zgoda VG. | 03/24/2018 |
| t-PA binds to Lys91 in the MBP NH2-terminal region and PLG binds to Lys122 in the MBP COOH-terminal region. This proximity promotes the activation of PLG by t-PA. | Myelin basic protein stimulates plasminogen activation via tissue plasminogen activator following binding to independent l-lysine-containing domains.
Gonzalez-Gronow M, Fiedler JL, Farias Gomez C, Wang F, Ray R, Ferrell PD, Pizzo SV. | 08/19/2017 |
| Specific sites of post-translational modifications in multiple sclerosis patients are localized in two zones of MBP suggests that these regions may be involved in antigen recognition by the body's immune surveillance machinery | Isoaspartic acid is present at specific sites in myelin basic protein from multiple sclerosis patients: could this represent a trigger for disease onset?
Friedrich MG, Hancock SE, Raftery MJ, Truscott RJ., Free PMC Article | 06/24/2017 |
| Results provide novel insights into the role of genetic variation within the MBP gene predicting multiple sclerosis clinical course, both directly and by interaction with known environmental MS risk factors | Variation within MBP gene predicts disease course in multiple sclerosis.
Zhou Y, Simpson S Jr, Charlesworth JC, van der Mei I, Lucas RM, Ponsonby AL, AUSLONG Investigators Group, Taylor BV., Free PMC Article | 04/29/2017 |
| Pathway analysis demonstrated that the majority of the differentially expressed genes (23.3%) were involved in cytokinecytokine receptor interaction. Subsequent to GolliMBP knockdown, the mechanisms that changed the biological characteristics of Jurkat cells were complex, involving numerous types of functional proteins, and metabolic and signaling pathway | Changes of gene expression in T lymphocytes following Golli‑MBP gene RNA interference.
Xu J, Zhu D, Shan J, Fan Y., Free PMC Article | 04/22/2017 |
| Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro. | Deimination of the myelin basic protein decelerates its proteasome-mediated metabolism.
Kuzina ES, Kudriaeva AA, Glagoleva IS, Knorre VD, Gabibov AG, Belogurov AA. | 02/4/2017 |
| This study observed a significantly increased myelin basic protein (MBP) and nuclear distribution protein nudE-like 1 (NDEL1) mRNA levels in FEP patients compared with controls. | Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis.
Ota VK, Noto C, Santoro ML, Spindola LM, Gouvea ES, Carvalho CM, Santos CM, Xavier G, Higuchi CH, Yonamine C, Moretti PN, Abílio VC, Hayashi MA, Brietzke E, Gadelha A, Cordeiro Q, Bressan RA, Belangero SI. | 10/8/2016 |
| myelin basic protein has a role in activating CD4+ and CD8+ T lymphocytes in multiple sclerosis | Early activation of CD4+ and CD8+ T lymphocytes by myelin basic protein in subjects with MS.
Arneth B., Free PMC Article | 07/30/2016 |
| B cells from relapsing-remitting multiple sclerosis patients produce TNFa and IL6, and present MBP85-99 peptide | Myelin Basic Protein-Induced Production of Tumor Necrosis Factor-α and Interleukin-6, and Presentation of the Immunodominant Peptide MBP85-99 by B Cells from Patients with Relapsing-Remitting Multiple Sclerosis.
Nielsen CH, Börnsen L, Sellebjerg F, Brimnes MK., Free PMC Article | 07/16/2016 |
| IL-17- and IL-22-secreting myelin specific CD4(+) T cells resistant to corticoids are associated with radiological activity of multiple sclerosis in early stages of the disease, mainly among Afrodescendant patients who, normally, have worse prognosis. | Interleukin-17- and interleukin-22-secreting myelin-specific CD4(+) T cells resistant to corticoids are related with active brain lesions in multiple sclerosis patients.
Wing AC, Hygino J, Ferreira TB, Kasahara TM, Barros PO, Sacramento PM, Andrade RM, Camargo S, Rueda F, Alves-Leon SV, Vasconcelos CC, Alvarenga R, Bento CA., Free PMC Article | 06/4/2016 |
| Studies indicate that all myelin basic protein (MBP) isoforms are intrinsically disordered proteins (IDPs) that interact via molecular recognition fragments (MoRFs), which thereby undergo local disorder-to-order transitions. | MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.
Vassall KA, Bamm VV, Harauz G. | 04/2/2016 |
| Reduced myelin basic protein-induced CD4+ T-cell autoreactivity in interferon-beta-treated multiple sclerosis patients may be mediated by monocyte-derived interleukin-10 | Endogenous interferon-β-inducible gene expression and interferon-β-treatment are associated with reduced T cell responses to myelin basic protein in multiple sclerosis.
Börnsen L, Romme Christensen J, Ratzer R, Hedegaard C, Søndergaard HB, Krakauer M, Hesse D, Nielsen CH, Sorensen PS, Sellebjerg F., Free PMC Article | 12/5/2015 |