| MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation. | MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation.
Zeng J, Zhang L, Huang L, Yu X, Han L, Zheng Y, Wang T, Zhang N, Yang M. | 09/23/2024 |
| G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis. | G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis.
Wang W, Li D, Xu Q, Cheng J, Yu Z, Li G, Qiao S, Pan J, Wang H, Shi J, Zheng T, Sui G., Free PMC Article | 03/8/2024 |
| Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma. | Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma.
Han L, Huo Y, Huang L, Zheng Y, Yu X, Zhang N, Yang M. | 02/20/2024 |
| Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary Thyroid Cancer. | Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary Thyroid Cancer.
Zheng C, Wu H, Zhang S, Tian R, Long H, Zhang H, Guo X, Li D, Tan S, Zhu X. | 09/13/2023 |
| The transcription factor Maz is essential for normal eye development. | The transcription factor Maz is essential for normal eye development.
Medina-Martinez O, Haller M, Rosenfeld JA, O'Neill MA, Lamb DJ, Jamrich M., Free PMC Article | 08/28/2021 |
| Identification of the transcription factor MAZ as a regulator of erythropoiesis. | Identification of the transcription factor MAZ as a regulator of erythropoiesis.
Deen D, Butter F, Daniels DE, Ferrer-Vicens I, Ferguson DCJ, Holland ML, Samara V, Sloane-Stanley JA, Ayyub H, Mann M, Frayne J, Garrick D, Vernimmen D., Free PMC Article | 08/14/2021 |
| The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization. | The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization.
Xiao T, Li X, Felsenfeld G., Free PMC Article | 07/24/2021 |
| We have constructed the bichromatic fluorescent reporter driven by SAF/MAZ 5'-proximal promoter plasmids from which transactivation status of SAF-1 and SAF-3 alternative promoter could be monitored by EGFP and DsRed expression respectively | Revealing the alternative promoter usage of SAF/MAZ gene by bichromatic fluorescent reporter construct.
Ren J, Guo D, Wang X, Zhang C, Wang B, Gao Z., Free PMC Article | 07/27/2019 |
| genotypes TT (SHMT1 rs4925166), CC (ERG rs2836425), GG (MAZ rs34286592), and GG (SHMT1 rs1979277) had the highest negative association (protective effect) with multiple sclerosis | Association of SHMT1, MAZ, ERG, and L3MBTL3 Gene Polymorphisms with Susceptibility to Multiple Sclerosis.
Nazari Mehrabani SZ, Shushizadeh MH, Abazari MF, Nouri Aleagha M, Ardalan A, Abdollahzadeh R, Azarnezhad A. | 06/29/2019 |
| MAZ is a potential therapeutic target to dampen STAT3 signaling in colon cancer. | Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling.
Triner D, Castillo C, Hakim JB, Xue X, Greenson JK, Nuñez G, Chen GY, Colacino JA, Shah YM., Free PMC Article | 06/22/2019 |
| High MAZ expression is associated with pancreatic cancer cell invasion. | The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling.
Maity G, Haque I, Ghosh A, Dhar G, Gupta V, Sarkar S, Azeem I, McGregor D, Choudhary A, Campbell DR, Kambhampati S, Banerjee SK, Banerjee S., Free PMC Article | 01/19/2019 |
| MAZ can promote the invasion and metastasis of hepatocellular carcinoma by inducing epithelial-mesenchymal transition (EMT). | MYC associated zinc finger protein promotes the invasion and metastasis of hepatocellular carcinoma by inducing epithelial mesenchymal transition.
Luo W, Zhu X, Liu W, Ren Y, Bei C, Qin L, Miao X, Tang F, Tang G, Tan S., Free PMC Article | 02/24/2018 |
| A quantitative association between MAZ-autoantibody optical density on ELISA and the cumulative inflammatory burden of atherosclerosis on (18)F-FDG PET/CT could be shown, suggesting MAZ-Ab as potential biomarker for atherosclerotic disease. | Anti-MYC-associated zinc finger protein antibodies are associated with inflammatory atherosclerotic lesions on (18)F-fluorodeoxyglucose positron emission tomography.
Ernst D, Weiberg D, Baerlecken NT, Schlumberger W, Daehnrich C, Schmidt RE, Bengel FM, Derlin T, Witte T. | 11/25/2017 |
| The data indicate that MAZ is essential to bypass MYB promoter repression by RB family members and to induce MYB expression. | MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter.
Álvaro-Blanco J, Urso K, Chiodo Y, Martín-Cortázar C, Kourani O, Arco PG, Rodríguez-Martínez M, Calonge E, Alcamí J, Redondo JM, Iglesias T, Campanero MR., Free PMC Article | 10/21/2017 |
| MAZ/FOXF2 axis can promote the proliferation of basal like breast cancer cells and suppress disease progression. | Dual function of MAZ mediated by FOXF2 in basal-like breast cancer: Promotion of proliferation and suppression of progression.
Yu ZH, Lun SM, He R, Tian HP, Huang HJ, Wang QS, Li XQ, Feng YM. | 09/30/2017 |
| Data suggest that long noncoding RNA PlncRNA1 and microRNA miR-34c bound together to regulate the expressions of MAZ, ZO-1 and occludin. | MiR-34c and PlncRNA1 mediated the function of intestinal epithelial barrier by regulating tight junction proteins in inflammatory bowel disease.
Chen T, Xue H, Lin R, Huang Z. | 06/24/2017 |
| a transcriptional factor, Myc-associated zinc finger protein (MAZ), plays an important role in ADAM10 transcription in response to CT-1 in neural stem/progenitor cells. | MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis.
Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y., Free PMC Article | 12/31/2016 |
| Akt phosphorylates MAZ at Thr385, and the phosphorylated MAZ is released from the p53 promoter, leading to transcriptional activation of p53. | Akt phosphorylates myc-associated zinc finger protein (MAZ), releases P-MAZ from the p53 promoter, and activates p53 transcription.
Lee WP, Lan KH, Li CP, Chao Y, Lin HC, Lee SD. | 08/13/2016 |
| Myc-associated zinc-finger protein (MAZ) was identified as a direct target of miR-449a, mediating the tumor-suppressive effects. | MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein.
Yao Y, Ma J, Xue Y, Wang P, Li Z, Li Z, Hu Y, Shang X, Liu Y., Free PMC Article | 11/28/2015 |
| Studies show a feed-forward regulatory pathway in breast cancer cells where SAF-1 acts as a transcriptional inducer of Ras which in turn increases DNA-binding and transcriptional activities of SAF-1 which in turn, increases transcription of Ras. | Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer.
Ray A, Ray BK., Free PMC Article | 09/26/2015 |
| In conclusion, our present study indicated that miR-34c regulated the permeability of BTB via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5. | miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5.
Zhao L, Wang P, Liu Y, Ma J, Xue Y. | 02/14/2015 |
| Role of MAZ in prostate cancer and its interaction with androgen receptor were investigated. siRNA knockdown of AR significantly decreased MAZ expression, and knockdown of MAZ significantly increased the expression of AR. | The prostate cancer-up-regulated Myc-associated zinc-finger protein (MAZ) modulates proliferation and metastasis through reciprocal regulation of androgen receptor.
Jiao L, Li Y, Shen D, Xu C, Wang L, Huang G, Chen L, Yang Y, Yang C, Yu Y, Sun Y. | 10/26/2013 |
| these findings reveal that SAF-1 is a hitherto unrecognized participant in inducing VEGF expression in triple-negative breast cancer cells, an aggressive form of breast cancer that currently lacks effective treatment options. | Control of VEGF expression in triple-negative breast carcinoma cells by suppression of SAF-1 transcription factor activity.
Ray A, Dhar S, Ray BK. | 12/17/2011 |
| Existence of multiple promoters regulation MAZ, which is expressed during inflammation. | SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation.
Ray A, Dhar S, Shakya A, Ray P, Okada Y, Ray BK. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Association and mutation analyses of 16p11.2 autism candidate genes.
Kumar RA, Marshall CR, Badner JA, Babatz TD, Mukamel Z, Aldinger KA, Sudi J, Brune CW, Goh G, Karamohamed S, Sutcliffe JS, Cook EH, Geschwind DH, Dobyns WB, Scherer SW, Christian SL., Free PMC Article | 03/25/2009 |