| Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family. | Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
Sun X, Jing L, Li F, Zhang M, Diao X, Zhuang J, Rastinejad F, Wu D., Free PMC Article | 11/19/2022 |
| Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies. | Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
Cooper AM, Nutter CA, Kuyumcu-Martinez MN, Wright CW., Free PMC Article | 05/28/2022 |
| Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1beta. | Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β.
Zhang M, Hu Y, Yang F, Zhang J, Zhang J, Yu W, Wang M, Lv X, Li J, Bai T, Chang F., Free PMC Article | 05/14/2022 |
| AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity. | AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity.
Bourner LA, Muro I, Cooper AM, Choudhury BK, Bailey AO, Russell WK, Khanipov K, Golovko G, Wright CW., Free PMC Article | 05/14/2022 |
| The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis. | The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.
Zhang TP, Li R, Li HM, Xiang N, Tan Z, Wang GS, Li XM., Free PMC Article | 05/7/2022 |
| Hypoxia-inducible factor-1beta is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts. | Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts.
Sasagawa T, Nagamatsu T, Yanagisawa M, Fujii T, Shibuya M., Free PMC Article | 03/5/2022 |
| GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion. | GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
Yang X, Chen Y, Zhou Y, Wu C, Li Q, Wu J, Hu WW, Zhao WQ, Wei W, Wu CP, Jiang JT, Ji M. | 12/25/2021 |
| The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor. | The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
Haidar R, Henkler F, Kugler J, Rosin A, Genkinger D, Laux P, Luch A., Free PMC Article | 12/11/2021 |
| Detrimental effects of hypoxia on glomerular podocytes. | Detrimental effects of hypoxia on glomerular podocytes.
Singh AK, Kolligundla LP, Francis J, Pasupulati AK. | 08/7/2021 |
| Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene. | Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.
Schurman SH, O'Hanlon TP, McGrath JA, Gruzdev A, Bektas A, Xu H, Garantziotis S, Zeldin DC, Miller FW., Free PMC Article | 07/10/2021 |
| Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain. | Structural Models for the Dynamic Effects of Loss-of-Function Variants in the Human SIM1 Protein Transcriptional Activation Domain.
Coban MA, Blackburn PR, Whitelaw ML, Haelst MMV, Atwal PS, Caulfield TR., Free PMC Article | 06/26/2021 |
| Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO. | Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO.
Sasahira T, Kurihara-Shimomura M, Shimomura H, Bosserhoff AK, Kirita T. | 05/29/2021 |
| [Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.] | [Arylhydrocarbon receptor nuclear translocator (ARNT) in human skin during aging.].
Gunin AG, Golubtzova NN, Kornilova NK. | 09/26/2020 |
| Overexpression of the aryl hydrocarbon receptor nuclear translocator partially rescues fetoplacental angiogenesis in severe fetal growth restriction. | Overexpression of the aryl hydrocarbon receptor nuclear translocator partially rescues fetoplacental angiogenesis in severe fetal growth restriction.
Ji S, Xin H, Su EJ., Free PMC Article | 03/14/2020 |
| ARNT/HIF-1beta might represent a novel biomarker for risk stratification and prognosis of HRMM patients, as well as a potential therapeutic target for overcoming 1q21 gain- or microenvironment-mediated and acquired drug resistance in MM. | ARNT/HIF-1β links high-risk 1q21 gain and microenvironmental hypoxia to drug resistance and poor prognosis in multiple myeloma.
Wu C, Yang T, Liu Y, Lu Y, Yang Y, Liu X, Liu X, Ye L, Sun Y, Wang X, Li Q, Yang P, Yu X, Gao S, Kumar S, Jin F, Dai Y, Li W., Free PMC Article | 11/16/2019 |
| we showed that VRCZ metabolites plus UVA generated reactive oxygen species and resultant DNA damage of the epidermis, but did not induce substantial apoptosis in human keratinocytes (KCs). Furthermore, VRCZ per se stimulates aryl hydrocarbon receptor (AhR) and upregulates COX-2, which is a pivotal enzyme for the promotion of UV-associated tumors, in an AhR-ARNT dependent manner of the classical (genomic) pathway. | Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation.
Ikeya S, Sakabe JI, Yamada T, Naito T, Tokura Y., Free PMC Article | 10/5/2019 |
| We identified a protective mechanism controlled by the transcription factor ARNT that effectively inhibits progression of chronic kidney injury by transcriptional induction of ALK3, the principal mediator of antifibrotic and proregenerative bone morphogenetic protein-signaling (BMP-signaling) responses. | Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure.
Tampe B, Tampe D, Nyamsuren G, Klöpper F, Rapp G, Kauffels A, Lorf T, Zeisberg EM, Müller GA, Kalluri R, Hakroush S, Zeisberg M., Free PMC Article | 09/21/2019 |
| When multipke myeloma patients were compared to controls, a protective role of CG genotype compared to CC in HIF-1beta (rs2228099) for MM development was observed (OR = 0.65; CI 0.45-0.95; p = 0.026). | Selected Genetic Polymorphisms Associated with Hypoxia and Multidrug Resistance in Monoclonal Gammopathies Patients.
Almasi M, Besse L, Brozova L, Jarkovsky J, Bezdekova R, Pour L, Minarik J, Kessler P, Pavlíček P, Roziakova L, Penka M, Hájek R, Vasku A, Sevcikova S. | 09/7/2019 |
| Hypoxia-inducible factor (HIF)-1 is a transcription factor comprised of HIF-1a and HIF-1b subunits that play a critical role in alcohol-mediated organ dysfunction. This review provides a comprehensive analysis of recent studies examining the relationship between HIF-1alpha and alcohol consumption as it relates to multiple organ injury and potential therapies to mitigate alcohol's effects. | Role of HIF-1α in Alcohol-Mediated Multiple Organ Dysfunction.
Morris NL, Yeligar SM., Free PMC Article | 06/1/2019 |
| Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF1A and HIF1B binding to a MYC enhancer. | Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer.
Grampp S, Platt JL, Lauer V, Salama R, Kranz F, Neumann VK, Wach S, Stöhr C, Hartmann A, Eckardt KU, Ratcliffe PJ, Mole DR, Schödel J., Free PMC Article | 08/25/2018 |
| in transcriptionally active heterodimer with AHR, which recognizes the dioxin response element (DRE) in the promoter of downstream genes, right next to the DRE-docking sites is the extensive dimerization surface that is more hydrophobic than other surface areas, indicating that the dimerization interface of the AHR transcription complex is largely dictated by hydrophobic contacts | Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.
Seok SH, Lee W, Jiang L, Molugu K, Zheng A, Li Y, Park S, Bradfield CA, Xing Y., Free PMC Article | 05/19/2018 |
| Here the authors examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. | NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Wu D, Su X, Potluri N, Kim Y, Rastinejad F., Free PMC Article | 12/16/2017 |
| Findings reveal that certain blood cancers rely on ARNT isoform 1 to potentiate proliferation by antagonizing RelB and p53-dependent cell cycle arrest and apoptosis. | Aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms control lymphoid cancer cell proliferation through differentially regulating tumor suppressor p53 activity.
Gardella KA, Muro I, Fang G, Sarkar K, Mendez O, Wright CW., Free PMC Article | 12/2/2017 |
| The structure clearly disclosed that AhRR competitively represses AhR binding to ARNT and target DNA and further suggested the existence of an AhRR-ARNT-specific repression mechanism. This study provides a structural basis for understanding the mechanism by which AhRR represses AhR-mediated gene transcription. | The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription.
Sakurai S, Shimizu T, Ohto U., Free PMC Article | 11/4/2017 |
| Study showed that polymorphism rs2228099 of the ARNT gene could be a novel susceptibility gene to essential hypertension. | A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility.
Polonikov AV, Bushueva OY, Bulgakova IV, Freidin MB, Churnosov MI, Solodilova MA, Shvetsov YD, Ivanov VP. | 10/14/2017 |