| Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. | Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus.
Rashid I, Hammel M, Sverzhinsky A, Tsai MS, Pascal JM, Tainer JA, Tomkinson AE., Free PMC Article | 08/8/2024 |
| Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer. | Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer.
Deng F, Laasik M, Salminen L, Lapatto L, Huhtinen K, Li Y, Hautaniemi S, Hynninen J, Niemi M, Lehtonen R. | 05/28/2023 |
| Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity. | Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity.
McNally JR, Ames AM, Admiraal SJ, O'Brien PJ., Free PMC Article | 02/4/2023 |
| Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis. | Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis.
Bian R, Dang W, Song X, Liu L, Jiang C, Yang Y, Li Y, Li L, Li X, Hu Y, Bao R, Liu Y., Free PMC Article | 03/26/2022 |
| Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy. | Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.
Bonora E, Chakrabarty S, Kellaris G, Tsutsumi M, Bianco F, Bergamini C, Ullah F, Isidori F, Liparulo I, Diquigiovanni C, Masin L, Rizzardi N, Cratere MG, Boschetti E, Papa V, Maresca A, Cenacchi G, Casadio R, Martelli P, Matera I, Ceccherini I, Fato R, Raiola G, Arrigo S, Signa S, Sementa AR, Severino M, Striano P, Fiorillo C, Goto T, Uchino S, Oyazato Y, Nakamura H, Mishra SK, Yeh YS, Kato T, Nozu K, Tanboon J, Morioka I, Nishino I, Toda T, Goto YI, Ohtake A, Kosaki K, Yamaguchi Y, Nonaka I, Iijima K, Mimaki M, Kurahashi H, Raams A, MacInnes A, Alders M, Engelen M, Linthorst G, de Koning T, den Dunnen W, Dijkstra G, van Spaendonck K, van Gent DC, Aronica EM, Picco P, Carelli V, Seri M, Katsanis N, Duijkers FAM, Taniguchi-Ikeda M, De Giorgio R. | 09/25/2021 |
| Human DNA ligases in replication and repair. | Human DNA ligases in replication and repair.
Sallmyr A, Rashid I, Bhandari SK, Naila T, Tomkinson AE., Free PMC Article | 03/28/2021 |
| Altered DNA ligase activity in human disease. | Altered DNA ligase activity in human disease.
Tomkinson AE, Naila T, Khattri Bhandari S., Free PMC Article | 02/6/2021 |
| An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIalpha within a flexible DNA repair complex. | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.
Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai MS, Ellenberger T, Pascal JM, Kim IK, Tainer JA, Tomkinson AE., Free PMC Article | 01/23/2021 |
| MM express elevated MALAT1 and involve in alternative non-homozygous end joining (A-NHEJ) pathway by binding to PARP1 and LIG3, two key components of the A-NHEJ protein complex. | Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma.
Hu Y, Lin J, Fang H, Fang J, Li C, Chen W, Liu S, Ondrejka S, Gong Z, Reu F, Maciejewski J, Yi Q, Zhao JJ., Free PMC Article | 06/15/2019 |
| Data report that polymorphisms in LIG3 gene are not associated with the susceptibility to gastric cancer. The study helps to provide novel insight into the role of LIG3 polymorphisms in gastric cancer risk. | LIG3 gene polymorphisms and risk of gastric cancer in a Southern Chinese population.
Hua RX, Zhuo Z, Zhu J, Zhang SD, Xue WQ, Li XZ, He J, Jia WH. | 06/15/2019 |
| High lig3 expression is associated with multiple myeloma. | miR-22 suppresses DNA ligase III addiction in multiple myeloma.
Caracciolo D, Di Martino MT, Amodio N, Morelli E, Montesano M, Botta C, Scionti F, Talarico D, Altomare E, Gallo Cantafio ME, Zuccalà V, Maltese L, Todoerti K, Rossi M, Arbitrio M, Neri A, Tagliaferri P, Tassone P., Free PMC Article | 05/25/2019 |
| The homozygotes of rs1052536 TT were associated with an increased risk for NTDs than CC, and variants of rs1052536 T were associated with an increased risk of Neural Tube Defects. The stratified analysis showed that TT genotype of rs1052536 increased the risk of anencephaly and the T allele significantly increased the risk of cranial Neural Tube Defects. | Polymorphism rs1052536 in Base Excision Repair Gene Is a Risk Factor in a High-Risk Area of Neural Tube Defects in China.
Li G, Wang X, Wang X, Guan Z, Guo J, Wang F, Zhang J, Niu B, Zhang T, Wang J, Yang J., Free PMC Article | 11/3/2018 |
| single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I | Kinetic analyses of single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I.
McNally JR, O'Brien PJ., Free PMC Article | 10/14/2017 |
| The g.29661G>A and g.29059C>T polymorphisms of LIG3 may play a role in the keratoconus and Fuchs endothelial corneal dystrophy pathogenesis and can be considered as markers in these diseases. | Polymorphism of the LIG3 gene in keratoconus and Fuchs endothelial corneal dystrophy.
Synowiec E, Wojcik KA, Izdebska J, Binczyk E, Szaflik J, Blasiak J, Szaflik JP. | 05/7/2016 |
| A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III. | A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III.
Singh PK, Mistry KN. | 03/19/2016 |
| In the context of tyrosine kinase-activated leukemias, c-MYC contributes to aberrant DNA repair through downstream targets LIG3 and PARP1 up-regulation. | c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias.
Muvarak N, Kelley S, Robert C, Baer MR, Perrotti D, Gambacorti-Passerini C, Civin C, Scheibner K, Rassool FV., Free PMC Article | 02/6/2016 |
| Domains constituting the LigIII catalytic core collaborate and are essential for formation of a DNA-bridging intermediate by adenylated LigIII that positions a pair of blunt-ended duplex DNAs for efficient and specific intermolecular ligation. | Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.
Kukshal V, Kim IK, Hura GL, Tomkinson AE, Tainer JA, Ellenberger T., Free PMC Article | 11/28/2015 |
| there is an absolute requirement for fully functional DNA ligase III (LIG3), but not ligase IV (LIG4), to facilitate the escape from a telomere-driven crisis. | Escape from telomere-driven crisis is DNA ligase III dependent.
Jones RE, Oh S, Grimstead JW, Zimbric J, Roger L, Heppel NH, Ashelford KE, Liddiard K, Hendrickson EA, Baird DM. | 05/30/2015 |
| LIGIII plays a role in additional EJing repair pathway only in the absence of Ku. | DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells.
Oh S, Harvey A, Zimbric J, Wang Y, Nguyen T, Jackson PJ, Hendrickson EA., Free PMC Article | 04/25/2015 |
| Results show that overexpression of DNA ligase III in mitochondria improves mitochondrial base excision repair and enhances cell survival after oxidative stress. | Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.
Akbari M, Keijzers G, Maynard S, Scheibye-Knudsen M, Desler C, Hickson ID, Bohr VA., Free PMC Article | 11/22/2014 |
| data confirm previous work showing that Lig3 is required to maintain mtDNA integrity and function, and highlight a new function of ATM in regulating DNA Lig3 stability and consequently mtDNA repair | Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.
Sharma NK, Lebedeva M, Thomas T, Kovalenko OA, Stumpf JD, Shadel GS, Santos JH., Free PMC Article | 07/26/2014 |
| Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. | Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway.
Della-Maria J, Zhou Y, Tsai MS, Kuhnlein J, Carney JP, Paull TT, Tomkinson AE., Free PMC Article | 11/26/2011 |
| Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy. | Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy.
Murray RJ, Tanteles GA, Mills J, Perry A, Peat I, Osman A, Chan S, Cheung KL, Chakraborti PR, Woodings PL, Barwell JG, Symonds RP, Talbot CJ. | 10/29/2011 |
| results establish a role for Lig3 in mitochondria, but distinguish it from its interacting protein Xrcc1 | Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair.
Simsek D, Furda A, Gao Y, Artus J, Brunet E, Hadjantonakis AK, Van Houten B, Shuman S, McKinnon PJ, Jasin M., Free PMC Article | 03/26/2011 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.
Shen M, Menashe I, Morton LM, Zhang Y, Armstrong B, Wang SS, Lan Q, Hartge P, Purdue MP, Cerhan JR, Grulich A, Cozen W, Yeager M, Holford TR, Vajdic CM, Davis S, Leaderer B, Kricker A, Severson RK, Zahm SH, Chatterjee N, Rothman N, Chanock SJ, Zheng T., Free PMC Article | 12/5/2010 |