| The potential pro-metastatic role of Lim1 in advanced clear cell renal cell carcinoma in vitro, ex vivo, and in vivo in a nude mouse model. Lim1 was found constitutively expressed in all metastatic tissues. Lim1 silencing decreased pulmonary metastasis in the in vivo model. Lim1 is involved in the expression of various proteins regulating cell movements and EMT, and induced clonogenicity in CCC cells. | The Lim1 oncogene as a new therapeutic target for metastatic human renal cell carcinoma.
Hamaidi I, Coquard C, Danilin S, Dormoy V, Béraud C, Rothhut S, Barthelmebs M, Benkirane-Jessel N, Lindner V, Lang H, Massfelder T. | 03/16/2019 |
| Report novel missense mutation in LHX1 in congenital absence of the uterus and vagina which could change the transcriptional activity of LHX1 and its effect on the regulation of the downstream target gene GSC. | Identification and functional analysis of a novel LHX1 mutation associated with congenital absence of the uterus and vagina.
Zhang W, Zhou X, Liu L, Zhu Y, Liu C, Pan H, Xing Q, Wang J, Wang X, Zhang X, Cao Y, Wang B., Free PMC Article | 02/24/2018 |
| Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4, HNF1B, and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%. | Genetic analysis of Mayer-Rokitansky-Kuster-Hauser syndrome in a large cohort of families.
Williams LS, Demir Eksi D, Shen Y, Lossie AC, Chorich LP, Sullivan ME, Phillips JA 3rd, Erman M, Kim HG, Alper OM, Layman LC., Free PMC Article | 08/19/2017 |
| Data have identified TBX6 as a new gene associated with Mullerian aplasia. The results also support the relevance of LHX1 and CNVs in the development of this congenital malformation. | TBX6, LHX1 and copy number variations in the complex genetics of Müllerian aplasia.
Sandbacka M, Laivuori H, Freitas É, Halttunen M, Jokimaa V, Morin-Papunen L, Rosenberg C, Aittomäki K., Free PMC Article | 07/19/2014 |
| study concludes that heterozygous mutations of LHX1 might be one cause of the Mayer-Rokitansky-Kuster-Hauser syndrome in a subgroup of patients | Frame shift mutation of LHX1 is associated with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome.
Ledig S, Brucker S, Barresi G, Schomburg J, Rall K, Wieacker P. | 01/12/2013 |
| Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas. | Functional genomics identifies drivers of medulloblastoma dissemination.
Mumert M, Dubuc A, Wu X, Northcott PA, Chin SS, Pedone CA, Taylor MD, Fults DW., Free PMC Article | 12/22/2012 |
| Lim1/LIM1 expression in neonatal, adult mouse and human endometrium suggesting Lim1/LIM1 may have a role in endometrial development and remodelling | Lim1/LIM1 is expressed in developing and adult mouse and human endometrium.
Ye L, Evans J, Gargett CE. | 10/6/2012 |
| Mutations in the coding regions of LHX1 may not be a common genetic etiologic factor involved in Han Chinese patients with mullerian duct abnormalities. | LHX1 mutation screening in 96 patients with müllerian duct abnormalities.
Xia M, Zhao H, Qin Y, Mu Y, Wang J, Bian Y, Ma J, Chen ZJ. | 04/28/2012 |
| Eleven dysplastic kidneys showed no expression of LIM1. In contrast, 12 of 32 nephroblastomas showed nuclear positivity. | Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas.
Guertl B, Senanayake U, Nusshold E, Leuschner I, Mannweiler S, Ebner B, Hoefler G. | 12/3/2011 |
| findings establish that the developmental marker Lim1 acts as an oncogene in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma | LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.
Dormoy V, Béraud C, Lindner V, Thomas L, Coquard C, Barthelmebs M, Jacqmin D, Lang H, Massfelder T. | 06/18/2011 |
| Lim1 (also known as Lhx1) gene consists of a DNA-binding homeodomain and 2 cysteine-rich LIM domains, which may participate in protein to protein interactions, and encodes a transcription factor. | The role of genes in the development of Mullerian anomalies: where are we today?
Christopoulos P, Gazouli M, Fotopoulou G, Creatsas G. | 02/1/2010 |