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    LDHC lactate dehydrogenase C [ Homo sapiens (human) ]

    Gene ID: 3948, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy.

    Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy.
    Naik A, Decock J., Free PMC Article

    04/16/2022
    Association between serum lactate dehydrogenase and 60-day mortality in Chinese Hakka patients with acute myeloid leukemia: A cohort study.

    Association between serum lactate dehydrogenase and 60-day mortality in Chinese Hakka patients with acute myeloid leukemia: A cohort study.
    Xiao Z, Gong R, Chen X, Xiao D, Luo S, Ji Y., Free PMC Article

    03/12/2022
    Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer.

    Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer.
    Cui Z, Chen Y, Hu M, Lin Y, Zhang S, Kong L, Chen Y.

    09/26/2020
    a novel association between the methylation status of CpG sites within LDHC and the development of insulin autoantibodies in the first years of life

    Allele-specific methylation of type 1 diabetes susceptibility genes.
    Kindt ASD, Fuerst RW, Knoop J, Laimighofer M, Telieps T, Hippich M, Woerheide MA, Wahl S, Wilson R, Sedlmeier EM, Hommel A, Todd JA, Krumsiek J, Ziegler AG, Bonifacio E.

    03/2/2019
    Lactate dehydrogenase C may act as a novel biomarker for renal cell carcinoma progression and a potential therapeutic target for the treatment of renal cell carcinoma.

    Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma.
    Hua Y, Liang C, Zhu J, Miao C, Yu Y, Xu A, Zhang J, Li P, Li S, Bao M, Yang J, Qin C, Wang Z.

    04/8/2017
    three uniquely identified proteins (CDK6 , galectin-3-binding protein and LDH C) were found, which show tight connection with prostate cancer and presence of all of them was previously linked to certain aspects of prostate cancer

    Differences in urinary proteins related to surgical margin status after radical prostatectomy.
    Heger Z, Michalek P, Guran R, Cernei N, Duskova K, Vesely S, Anyz J, Stepankova O, Zitka O, Adam V, Kizek R.

    08/13/2016
    Down-regulated LDH-C4 expression is significantly correlated with lowered enzyme activity in human spermatozoa.

    Quick histochemical staining method for measuring lactate dehydrogenase C4 activity in human spermatozoa.
    Cui Z, Chen L, Liu Y, Zeng Z, Lan F.

    01/30/2016
    This is the first report to show a positive correlation between LDH-3 and hemolytic parameters in sickle cell anemia.

    Lactate dehydrogenase isoenzyme 3 and hemolysis in sickle cell anemia: a possible correlation?
    Mecabo G, Yamamoto M, Biassi TP, Figueiredo MS.

    08/29/2015
    Results show that S-100B, MIA and LDH levels were significantly higher in patients with advanced melanoma than in disease-free patients or healthy controls.

    Evaluation of multiple serum markers in advanced melanoma.
    Díaz-Lagares A, Alegre E, Arroyo A, González-Cao M, Zudaire ME, Viteri S, Martín-Algarra S, González A.

    02/4/2012
    Elevated serum LDH isoenzymes and AST indicate a disturbance (of uncertain clinical significance) within multiple extraosseous tissues when there is CLCN7 deficiency.

    Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders.
    Whyte MP, Kempa LG, McAlister WH, Zhang F, Mumm S, Wenkert D.

    02/26/2011
    hLdhc expression in cancer cells was regulated by transcription factor Sp1 and CREB and promoter CGI methylation

    Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation.
    Tang H, Goldberg E.

    01/21/2010
    LDH3 is a supporting diagnostic marker in cases of chronic tuberculosis.

    Elevated level of serum LDH2 and LDH3 in sputum three positive TB patients of Sahariya tribe: a preliminary study.
    Sharma PR, Jain S, Tiwari PK.

    01/21/2010
    LDH3 was increased in essential thrombocythemia. This isoenzymatic pattern could be expression of a metabolic adaptation.

    Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?
    Mazzotta S, Guerranti R, Gozzetti A, Bucalossi A, Bocchia M, Sammassimo S, Petralia S, Ogueli GI, Lauria F.

    01/21/2010
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