| Silencing of RhoC induces macrophage M1 polarization to inhibit migration and invasion in colon cancer via regulating the PTEN/FOXO1 pathway. | Silencing of RhoC induces macrophage M1 polarization to inhibit migration and invasion in colon cancer via regulating the PTEN/FOXO1 pathway.
Yang B, Wang L, Tian Z., Free PMC Article | 01/21/2023 |
| LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling. | LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling.
Liu X, Wang M, Zhang L, Huang L., Free PMC Article | 12/31/2022 |
| RhoC in association with TET2/WDR5 regulates cancer stem cells by epigenetically modifying the expression of pluripotency genes. | RhoC in association with TET2/WDR5 regulates cancer stem cells by epigenetically modifying the expression of pluripotency genes.
Thomas P, Srivastava S, Udayashankara AH, Damodaran S, Yadav L, Mathew B, Suresh SB, Mandal AK, Srikantia N., Free PMC Article | 12/17/2022 |
| RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination. | RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination.
Rong G, Pan Z, Ding M, Wang L. | 02/5/2022 |
| A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC. | A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC.
Xu M, Huang S, Dong X, Chen Y, Li M, Shi W, Wang G, Huang C, Wang Q, Liu Y, Sun P, Yang S, Xiang R, Chang A., Free PMC Article | 01/29/2022 |
| RNF168 promotes RHOC degradation by ubiquitination to restrain gastric cancer progression via decreasing HDAC1 expression. | RNF168 promotes RHOC degradation by ubiquitination to restrain gastric cancer progression via decreasing HDAC1 expression.
Xu Y, Feng Y, Sun Z, Li Q. | 08/14/2021 |
| Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis. | Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis.
Schimmel L, de Ligt A, Tol S, de Waard V, van Buul JD., Free PMC Article | 07/17/2021 |
| Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer. | Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.
Keller L, Tardy C, Ligat L, Gilhodes J, Filleron T, Bery N, Rochaix P, Aquilina A, Bdioui S, Roux T, Trinquet E, Favre G, Olichon A. | 07/10/2021 |
| RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells. | RNF180 mediates STAT3 activity by regulating the expression of RhoC via the proteasomal pathway in gastric cancer cells.
Wu Z, Liu H, Sun W, Du Y, He W, Guo S, Chen L, Zhao Z, Wang P, Liang H, Deng J., Free PMC Article | 05/15/2021 |
| Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC. | Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC.
Guo Y, Wang J, Zhou K, Lv J, Wang L, Gao S, Keller ET, Zhang ZS, Wang Q, Yao Z. | 01/23/2021 |
| RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A. | RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.
Richter L, Oberländer V, Schmidt G., Free PMC Article | 12/12/2020 |
| Leukemia-Associated Rho Guanine Nucleotide Exchange Factor and Ras Homolog Family Member C Play a Role in Glioblastoma Cell Invasion and Resistance. | Leukemia-Associated Rho Guanine Nucleotide Exchange Factor and Ras Homolog Family Member C Play a Role in Glioblastoma Cell Invasion and Resistance.
Ding Z, Dong Z, Yang Y, Fortin Ensign SP, Sabit H, Nakada M, Ruggieri R, Kloss JM, Symons M, Tran NL, Loftus JC., Free PMC Article | 11/21/2020 |
| RhoC plays a pivotal role in MVECs angiogenesis, and the downregulation of RhoC expression could inhibit angiogenesis via the RhoC/MAPK and RhoC/ROCK signaling pathways. | Effects of RhoC downregulation on the angiogenesis characteristics of myeloma vascular endothelial cells.
Zhao Z, Liu K, Tian X, Sun M, Wei N, Zhu X, Yang H, Wang T, Jiang G, Chen K., Free PMC Article | 08/1/2020 |
| RhoC contributes to the Rac1-dependent restoration of endothelial barrier function. | RhoA, RhoB and RhoC differentially regulate endothelial barrier function.
Pronk MCA, van Bezu JSM, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL., Free PMC Article | 04/25/2020 |
| study indicates that miR-455 plays a suppressive role in hepatocellular carcinoma development by targeting RhoC-encoding mRNA | [miR-455 Inhibits HepG2 Cell Proliferation and Promotes Apoptosis by Targeting RhoC].
Xie SL, Wang M, Du XH, Zhao ZW, Lv GY. | 04/11/2020 |
| Results show that rhoC GTP-binding protein (RhoC)/Rho-associated, coiled-coil containing protein kinase 2 (ROCK2) may have a major effect on VM in hepatocellular carcinoma (HCC) via ERK/MMPs signaling and might be a potential therapeutic target for the treatment of HCC. | RhoC/ROCK2 promotes vasculogenic mimicry formation primarily through ERK/MMPs in hepatocellular carcinoma.
Zhang JG, Zhang DD, Liu Y, Hu JN, Zhang X, Li L, Mu W, Zhu GH, Li Q, Liu GL. | 02/8/2020 |
| the inhibition of RhoC and ROCK2 sensitizes tumor cells to irradiation. Based on transcriptomic analysis, we find that the gene network supporting DNA repair is enriched in RhoC overexpressing cells and this is also true for ROCK2hi cells, which have an enrichment of genes supporting DNA repair, cell survival and cell division. | RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer.
Pranatharthi A, Thomas P, Udayashankar AH, Bhavani C, Suresh SB, Krishna S, Thatte J, Srikantia N, Ross CR, Srivastava S., Free PMC Article | 02/1/2020 |
| Our review throws light on how RhoC, which is capable of modulating various phenotypes may be the apt core signaling candidate regulating disease progression. | RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target.
Thomas P, Pranatharthi A, Ross C, Srivastava S., Free PMC Article | 01/18/2020 |
| Pin1, RhoA and RhoC co-overexpressions are prognostic factor for metastatic hepatocellular carcinoma and predict poor recurrence-free survival. | Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients.
Ng L, Kwan V, Chow A, Yau TC, Poon RT, Pang R, Law WL., Free PMC Article | 01/4/2020 |
| ITGB1 and RHOC are potential predictors of recurrence and therapeutic targets for CRC, possibly predicting a high-risk group of stage II patients. | Biological Characteristics and Clinical Significance of ITGB1 and RHOC in Patients With Recurrent Colorectal Cancer.
Ha YJ, Tak KH, Kim SK, Kim CW, Lee JL, Roh SA, Cho DH, Kim SY, Kim YS, Kim JC. | 09/28/2019 |
| LncRNA TDRG1 overexpression induced tumor development and RhoC expression. | The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Chen S, Wang LL, Sun KX, Xiu YL, Zong ZH, Chen X, Zhao Y. | 11/24/2018 |
| This article summarizes recent progress on the mechanisms that control the expression of the three members of the Rho-like subfamily (RhoA, RhoB, and RhoC) at the level of gene transcription as well as their post-transcriptional regulation by microRNAs. [review] | Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases.
Nomikou E, Livitsanou M, Stournaras C, Kardassis D., Free PMC Article | 11/3/2018 |
| a SDF-1/CXCR4-RhoA and RhoC-ROS-cytoskeleton pathway that regulates Jurkat cell migration in response to SDF-1. | RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.
Luo J, Li D, Wei D, Wang X, Wang L, Zeng X. | 06/2/2018 |
| Studied the involvement in epithelial ovarian cancer (EOC) of lncRNA ABHD11-AS1 in and the regulation of EOC by RhoC. | Role of the lncRNA ABHD11-AS(1) in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC.
Wu DD, Chen X, Sun KX, Wang LL, Chen S, Zhao Y., Free PMC Article | 05/19/2018 |
| Out of multiple members of this family, RhoA and RhoC are important factors. RhoA is supposed to increase tumor proliferation when overexpressed while RhoC is responsible for tumor initiation. | ABCs of RhoGTPases indicating potential role as oncotargets.
Bora I, Shrivastava N. | 02/24/2018 |