| IPO5 promotes malignant progression of esophageal cancer through activating MMP7. | IPO5 promotes malignant progression of esophageal cancer through activating MMP7.
Li XF, Aierken AL, Shen L. | 04/3/2021 |
| X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking. | X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
Swale C, Da Costa B, Sedano L, Garzoni F, McCarthy AA, Berger I, Bieniossek C, Ruigrok RWH, Delmas B, Crépin T. | 10/31/2020 |
| DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import. | DDX56 inhibits type I interferon by disrupting assembly of IRF3-IPO5 to inhibit IRF3 nucleus import.
Li D, Fu S, Wu Z, Yang W, Ru Y, Shu H, Liu X, Zheng H., Free PMC Article | 09/26/2020 |
| IPO5 is an oncogene involved in CRC cell proliferation and migration. This highlights the significance of IPO5 in 5-fluorouracil-resistant CRC cells. The oncogenic function of IPO5 was mediated by promoting RAS signalling by increasing the nuclear translocation of RASAL2 | IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.
Zhang W, Lu Y, Li X, Zhang J, Lin W, Zhang W, Zheng L, Li X., Free PMC Article | 12/21/2019 |
| Results indicate that the interaction between FLIL33 and IPO5 is localized to a specific segment of the FLIL33 protein, is not required for nuclear localization of FLIL33, and protects FLIL33 from proteasome-dependent degradation. | The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation.
Clerman A, Noor Z, Fishelevich R, Lockatell V, Hampton BS, Shah NG, Salcedo MV, Todd NW, Atamas SP, Luzina IG., Free PMC Article | 12/1/2018 |
| importin-alpha5, which is a key regulator of interferon signaling following Ebola virus infection, as one putative target of miRNA. | Ebola virus encodes a miR-155 analog to regulate importin-α5 expression.
Liu Y, Sun J, Zhang H, Wang M, Gao GF, Li X., Free PMC Article | 08/5/2017 |
| The nuclear importin IPO5 was identified as a novel interacting protein of SMAD1. Overexpression of IPO5 in various cell lines specifically increases nuclear localization of BMP receptor-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 and BMP but not TGF-beta R-SMADs. | Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin.
Baas R, Sijm A, van Teeffelen HA, van Es R, Vos HR, Marc Timmers HT., Free PMC Article | 05/27/2017 |
| Importins, Impbeta, Kapbeta2, Imp4, Imp5, Imp7, Imp9, and Impalpha, show the H3 tail binding more tightly than the H4 tail. The H3 tail binds Kapbeta2 and Imp5 with KD values of 77 and 57 nm, respectively, and binds the other five Importins more weakly. | Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins.
Soniat M, Cağatay T, Chook YM., Free PMC Article | 05/20/2017 |
| Single nucleotide polymorphism in IPO5 gene is associated with Peripheral Arterial Disease. | Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population.
Matsukura M, Ozaki K, Takahashi A, Onouchi Y, Morizono T, Komai H, Shigematsu H, Kudo T, Inoue Y, Kimura H, Hosaka A, Shigematsu K, Miyata T, Watanabe T, Tsunoda T, Kubo M, Tanaka T., Free PMC Article | 06/11/2016 |
| IQGAP1 interacts with human importin-beta5 in HEK 293T cells. | IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling.
Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H., Free PMC Article | 03/8/2014 |
| In case of L7, importin beta2 or importin beta3 are preferentially used by clusters with a high import efficiency. | The quantitative assessment of the role played by basic amino acid clusters in the nuclear uptake of human ribosomal protein L7.
Tai LR, Chou CW, Lee IF, Kirby R, Lin A. | 03/30/2013 |
| The N-terminal of influenza A virus PB1 mediates its binding to host RanBP5. | Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5.
Hutchinson EC, Orr OE, Man Liu S, Engelhardt OG, Fodor E. | 09/24/2011 |
| The results of this study suggested that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia. | Genetic and functional study of the IPO5 gene in schizophrenia.
Wang ZQ, Liu Y, Wu N, Xu Q, Jin SZ, Ju GZ, Ye L, Liu LB, Zhang X, Wu J, Wang ZQ, Liu Y, Wu N, Xu Q, Jin SZ, Ju GZ, Ye L, Liu LB, Zhang X, Wu J. | 06/18/2011 |
| importin beta3 is essential for the nuclear import of RPL7. The import is mediated via the multifaceted basic amino acid clusters present in the NH(2)-region of RPL7, and is RanGTP-dependent | Importin β3 mediates the nuclear import of human ribosomal protein L7 through its interaction with the multifaceted basic clusters of L7.
Chou CW, Tai LR, Kirby R, Lee IF, Lin A. | 10/30/2010 |
| Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells. | Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells.
Komlodi-Pasztor E, Trostel S, Sackett D, Poruchynsky M, Fojo T., Free PMC Article | 01/21/2010 |
| These results suggest that karyopherin beta3 plays a crucial role in apo A-I secretion. | A novel function of karyopherin beta3 associated with apolipoprotein A-I secretion.
Chung KM, Cha SS, Jang SK. | 01/21/2010 |
| Lack of association of the KPNB3 locus in schizophrenia. | Lack of association of the KPNB3 locus in case-control samples.
Wu N, Zhang X, Sang H, Liu L, Ye L, Ju G, Liu S, Wang Z, Jin S, Wei J. | 01/21/2010 |
| HPV-16 E5 protein binds to karyopherin beta3. | Karyopherin beta3: a new cellular target for the HPV-16 E5 oncoprotein.
Krawczyk E, Hanover JA, Schlegel R, Suprynowicz FA., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic and functional study of the IPO5 gene in schizophrenia.
Wang ZQ, Liu Y, Wu N, Xu Q, Jin SZ, Ju GZ, Ye L, Liu LB, Zhang X, Wu J, Wang ZQ, Liu Y, Wu N, Xu Q, Jin SZ, Ju GZ, Ye L, Liu LB, Zhang X, Wu J. Is KPNB3 locus associated with schizophrenia?
Liu LB, Hu Y, Ju GZ, Zhang X, Xie L, Liu SZ, Shi JP, Yu YQ, Xu Q, Fan Y, Shen Y, Wei J. | 03/13/2008 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.
Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y, Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y. | 03/13/2008 |
| The present work suggests that the combination of the KPNA3 gene and the KPNB3 gene may increase a genetic risk for schizophrenia. | A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.
Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y, Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y. | 01/21/2010 |
| The KPNB3 locus may contain a disease-causing variant for schizophrenia. | The KPNB3 locus is associated with schizophrenia.
Wei J, Hemmings GP. | 01/21/2010 |
| HPV16 L2 interacts via its NLSs with a network of karyopherins and can enter the nucleus via several import pathways mediated by Kapalpha(2)beta(1) heterodimers, Kapbeta(2), and Kapbeta(3). | The l2 minor capsid protein of human papillomavirus type 16 interacts with a network of nuclear import receptors.
Darshan MS, Lucchi J, Harding E, Moroianu J., Free PMC Article | 01/21/2010 |
| L1 major capsid protein of human papillomavirus type 11 interacts with Kap beta3 nuclear import receptors | The L1 major capsid protein of human papillomavirus type 11 interacts with Kap beta2 and Kap beta3 nuclear import receptors.
Nelson LM, Rose RC, Moroianu J. | 01/21/2010 |
| RanBP5 acts as an import factor for the newly synthesized influenza A virus RNA-dependent-RNA polymerase by targeting the PB1-PA dimer to the nucleus. | Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex.
Deng T, Engelhardt OG, Thomas B, Akoulitchev AV, Brownlee GG, Fodor E., Free PMC Article | 01/21/2010 |