| Circular RNA hsa_circ_0008003 promotes the progression of non-small-cell lung cancer by sponging miR-548I and regulating KPNA4 expression. | Circular RNA hsa_circ_0008003 promotes the progression of non-small-cell lung cancer by sponging miR-548I and regulating KPNA4 expression.
Yang W, Yao Y, Yang S, Ke Y., Free PMC Article | 03/1/2023 |
| Human importin alpha3 and its N-terminal truncated form, without the importin-beta-binding domain, are oligomeric species with a low conformational stability in solution. | Human importin α3 and its N-terminal truncated form, without the importin-β-binding domain, are oligomeric species with a low conformational stability in solution.
Díaz-García C, Hornos F, Giudici AM, Cámara-Artigas A, Luque-Ortega JR, Arbe A, Rizzuti B, Alfonso C, Forwood JK, Iovanna JL, Gómez J, Prieto M, Coutinho A, Neira JL. | 06/18/2022 |
| Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner. | Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner.
Wang T, Zhang C, Wang S., Free PMC Article | 03/26/2022 |
| The nuclear localization sequence of the epigenetic factor RYBP binds to human importin alpha3. | The nuclear localization sequence of the epigenetic factor RYBP binds to human importin α3.
Neira JL, Jiménez-Alesanco A, Rizzuti B, Velazquez-Campoy A. | 09/25/2021 |
| Value of KPNA4 as a diagnostic and prognostic biomarker for hepatocellular carcinoma. | Value of KPNA4 as a diagnostic and prognostic biomarker for hepatocellular carcinoma.
Xu M, Liang H, Li K, Zhu S, Yao Z, Xu R, Lin N., Free PMC Article | 08/14/2021 |
| LINC00467 facilitates osteosarcoma progression by sponging miR217 to regulate KPNA4 expression. | LINC00467 facilitates osteosarcoma progression by sponging miR‑217 to regulate KPNA4 expression.
Yan J, Fang T, Zhang M, Zhou Q., Free PMC Article | 07/17/2021 |
| A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin. | A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin.
Neira JL, Rizzuti B, Jiménez-Alesanco A, Palomino-Schätzlein M, Abián O, Velázquez-Campoy A, Iovanna JL., Free PMC Article | 06/26/2021 |
| KPNA4 is involved in cataract formation via the nuclear import of p53. | KPNA4 is involved in cataract formation via the nuclear import of p53.
Ping X, Cheng Y, Bao J, Shi K, Zou J, Shentu X. | 05/1/2021 |
| KPNA4 regulated by miR-548b-3p promotes the malignant phenotypes of papillary thyroid cancer. | KPNA4 regulated by miR-548b-3p promotes the malignant phenotypes of papillary thyroid cancer.
Feng L, Wang R, Yang Y, Shen X, Shi Q, Lian M, Ma H, Fang J. | 02/6/2021 |
| STAT3-induced upregulation of circCCDC66 facilitates the progression of non-small cell lung cancer by targeting miR-33a-5p/KPNA4 axis. | STAT3-induced upregulation of circCCDC66 facilitates the progression of non-small cell lung cancer by targeting miR-33a-5p/KPNA4 axis.
Wang Y, Zhao W, Zhang S. | 02/2/2021 |
| Disease-specific alteration of karyopherin-alpha subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma. | Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma.
Hazawa M, Sakai K, Kobayashi A, Yoshino H, Iga Y, Iwashima Y, Lim KS, Chih-Cheng Voon D, Jiang YY, Horike SI, Lin DC, Wong RW., Free PMC Article | 11/28/2020 |
| miR-3619-5p inhibited cell proliferation and cisplatin resistance of cutaneous squamous cell carcinoma (CSCC) by regulating KPNA4 expression, suggesting that miR-3619-5p/KPNA4 pathway may represent a potential promising strategy for the treatment of patients with CSCC. | MiR-3619-5p hampers proliferation and cisplatin resistance in cutaneous squamous-cell carcinoma via KPNA4.
Zhang M, Luo H, Hui L. | 05/2/2020 |
| Development of a pipeline for automated, high-throughput analysis of PSPC1 paraspeckle protein isoforms reveals specific roles for KPNA2, KPNA4 and KPNA6 proteins. | Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins.
Major AT, Miyamoto Y, Lo CY, Jans DA, Loveland KL., Free PMC Article | 11/3/2018 |
| Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. | Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1.
Sankhala RS, Lokareddy RK, Begum S, Pumroy RA, Gillilan RE, Cingolani G., Free PMC Article | 04/21/2018 |
| Our results suggest a potential role of Hsa-miR-567 as a novel prognostic biomarker for BC and as regulator of KPNA4. | MicroRNA-567 dysregulation contributes to carcinogenesis of breast cancer, targeting tumor cell proliferation, and migration.
Bertoli G, Cava C, Diceglie C, Martelli C, Rizzo G, Piccotti F, Ottobrini L, Castiglioni I., Free PMC Article | 12/9/2017 |
| These results suggest that the Japanese encephalitis virus NS5 inhibits the induction of type I interferon by targeting KPNA3 and KPNA4. | Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB.
Ye J, Chen Z, Li Y, Zhao Z, He W, Zohaib A, Song Y, Deng C, Zhang B, Chen H, Cao S., Free PMC Article | 05/20/2017 |
| Our results showed that miR-181 family expression was closely correlated with TCGA subtypes and patients' overall survival, indicating that miR-181b. | Upregulation of miR-181s reverses mesenchymal transition by targeting KPNA4 in glioblastoma.
Wang H, Tao T, Yan W, Feng Y, Wang Y, Cai J, You Y, Jiang T, Jiang C., Free PMC Article | 08/6/2016 |
| Karyopherin alpha 3 and karyopherin alpha 4 proteins mediate the nuclear import of methyl-CpG binding protein 2. | Karyopherin α 3 and karyopherin α 4 proteins mediate the nuclear import of methyl-CpG binding protein 2.
Baker SA, Lombardi LM, Zoghbi HY., Free PMC Article | 12/5/2015 |
| miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy | MiR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin α4 and α5 in IgA nephropathy.
Bao H, Chen H, Zhu X, Zhang M, Yao G, Yu Y, Qin W, Zeng C, Zen K, Liu Z. | 12/20/2014 |
| upon DNA damage transport adaptor importin-alpha4 imports XPA into the nucleus in an ATR-dependent manner. | UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner.
Li Z, Musich PR, Cartwright BM, Wang H, Zou Y., Free PMC Article | 02/15/2014 |
| Importin alpha3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function. | Importin α3/Qip1 is involved in multiplication of mutant influenza virus with alanine mutation at amino acid 9 independently of nuclear transport function.
Sasaki Y, Hagiwara K, Kakisaka M, Yamada K, Murakami T, Aida Y., Free PMC Article | 07/20/2013 |
| Impalpha3 is an HIV integrase-interacting cofactor and is required for efficient HIV-1 nuclear import and replication. | Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication.
Ao Z, Danappa Jayappa K, Wang B, Zheng Y, Kung S, Rassart E, Depping R, Kohler M, Cohen EA, Yao X., Free PMC Article | 09/20/2010 |
| The papillomavirus E2 proteins preferentially interacted with alpha importins 3 and 5, and showed very weak or no interaction with the other three widely expressed alpha importins (alpha1, alpha 4, and alpha 7). | Common importin alpha specificity for papillomavirus E2 proteins.
Bian XL, Wilson VG., Free PMC Article | 07/26/2010 |
| stress-induced accumulation of non-ubiquitinated p53 in the cytoplasm promotes interaction with importin-alpha3 and rapid import | Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding.
Marchenko ND, Hanel W, Li D, Becker K, Reich N, Moll UM., Free PMC Article | 07/19/2010 |
| Expression of importin alpha3, a protein involved in p50/p65 nuclear import, was decreased in cells overexpressing PHB. | Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression.
Theiss AL, Jenkins AK, Okoro NI, Klapproth JM, Merlin D, Sitaraman SV., Free PMC Article | 04/12/2010 |