| Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD. | Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S., Free PMC Article | 09/6/2023 |
| GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer. | GLUT5-KHK axis-mediated fructose metabolism drives proliferation and chemotherapy resistance of colorectal cancer.
Shen Z, Li Z, Liu Y, Li Y, Feng X, Zhan Y, Lin M, Fang C, Fang Y, Deng H. | 05/7/2022 |
| USP36 promotes tumor growth of non-small cell lung cancer via increasing KHK-A expression by regulating c-MYC-hnRNPH1/H2 axis. | USP36 promotes tumor growth of non-small cell lung cancer via increasing KHK-A expression by regulating c-MYC-hnRNPH1/H2 axis.
Deng Q, Wu M, Deng J. | 03/5/2022 |
| KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1. | KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1.
Yang J, Yang S, Wang Q, Pang J, Wang Y, Wang H, Fu X. | 09/25/2021 |
| Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants. | Prevalence and cardiometabolic correlates of ketohexokinase gene variants among UK Biobank participants.
Johnston JA, Nelson DR, Bhatnagar P, Curtis SE, Chen Y, MacKrell JG., Free PMC Article | 08/28/2021 |
| Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. | Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer.
Kim J, Kang J, Kang YL, Woo J, Kim Y, Huh J, Park JW., Free PMC Article | 11/21/2020 |
| KHK-A has a role in antioxidative stress and hepatocellular carcinoma development that involves phosphorylating p62 | The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62.
Xu D, Li X, Shao F, Lv G, Lv H, Lee JH, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H, Lyu J, Lu Z., Free PMC Article | 05/30/2020 |
| Data indicate metabolic enzymes NAD kinase and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C as a tumor suppressor in KRAS(MUT) colorectal tumor xenograft. | Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.
Yau EH, Kummetha IR, Lichinchi G, Tang R, Zhang Y, Rana TM., Free PMC Article | 12/16/2017 |
| Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C. | Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase.
Le MT, Lanaspa MA, Cicerchi CM, Rana J, Scholten JD, Hunter BL, Rivard CJ, Randolph RK, Johnson RJ., Free PMC Article | 07/22/2017 |
| compared with normal hepatocytes, hepatocellular carcinoma (HCC) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc-dependent and heterogeneous nuclear ribonucleoprotein (hnRNP) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform. | A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.
Li X, Qian X, Peng LX, Jiang Y, Hawke DH, Zheng Y, Xia Y, Lee JH, Cote G, Wang H, Wang L, Qian CN, Lu Z., Free PMC Article | 06/3/2017 |
| myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha) activation of SF3B1 and SF3B1-mediated splice switching of KHK-A to KHK-C | HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Mirtschink P, Krishnan J, Grimm F, Sarre A, Hörl M, Kayikci M, Fankhauser N, Christinat Y, Cortijo C, Feehan O, Vukolic A, Sossalla S, Stehr SN, Ule J, Zamboni N, Pedrazzini T, Krek W., Free PMC Article | 08/1/2015 |
| These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease. | Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.
Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ., Free PMC Article | 01/10/2015 |
| This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 and SLC2A5 and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes. | Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals.
Le MT, Lobmeyer MT, Campbell M, Cheng J, Wang Z, Turner ST, Chapman AB, Boerwinkle E, Gums JG, Gong Y, Johnson RJ, Johnson JA., Free PMC Article | 07/13/2013 |
| In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose. | Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver.
Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, Li N, Roncal-Jimenez CA, Ishimoto T, Le M, Garcia GE, Thomas JB, Rivard CJ, Andres-Hernando A, Hunter B, Schreiner G, Rodriguez-Iturbe B, Sautin YY, Johnson RJ., Free PMC Article | 04/27/2013 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| The structure of the KHK-A ternary complex revealed an active site with fructose & the ATP analogue in positions ready for phosphorylation. The effects of the pathogenic mutations Gly40Arg & Ala43Thr have been modelled in the context of the KHK structure. | Structures of alternatively spliced isoforms of human ketohexokinase.
Trinh CH, Asipu A, Bonthron DT, Phillips SE., Free PMC Article | 01/21/2010 |
| Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. | Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.
Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, Henderson GN, Johnson RJ, Sautin YY., Free PMC Article | 01/21/2010 |
| ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria. | Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria.
Asipu A, Hayward BE, O'Reilly J, Bonthron DT. | 01/21/2010 |
| The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma | The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma.
Hwa JS, Kim HJ, Goo BM, Park HJ, Kim CW, Chung KH, Park HC, Chang SH, Kim YW, Kim DR, Cho GJ, Choi WS, Kang KR. | 01/21/2010 |