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    ARF1 ARF GTPase 1 [ Homo sapiens (human) ]

    Gene ID: 375, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Variations associated with neurodevelopmental disorders affect ARF1 function and cortical development.

    Variations associated with neurodevelopmental disorders affect ARF1 function and cortical development.
    Ishiguro T, Noda M, Nishikawa M, Nagata KI, Ito H.

    11/7/2024
    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.

    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
    Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y, Li T, Jiang Y.

    09/12/2024
    THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axis.

    THUMPD3-AS1 inhibits ovarian cancer cell apoptosis through the miR-320d/ARF1 axis.
    Mu Q, Wang X, Huang K, Xia B, Bi S, Kong Y.

    07/29/2024
    ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.

    ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
    Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ., Free PMC Article

    11/7/2023
    ARF1-related disorder: phenotypic and molecular spectrum.

    ARF1-related disorder: phenotypic and molecular spectrum.
    de Sainte Agathe JM, Pode-Shakked B, Naudion S, Michaud V, Arveiler B, Fergelot P, Delmas J, Keren B, Poirsier C, Alkuraya FS, Tabarki B, Bend E, Davis K, Bebin M, Thompson ML, Bryant EM, Wagner M, Hannibal I, Lenberg J, Krenn M, Wigby KM, Friedman JR, Iascone M, Cereda A, Miao T, LeGuern E, Argilli E, Sherr E, Caluseriu O, Tidwell T, Bayrak-Toydemir P, Hagedorn C, Brugger M, Vill K, Morneau-Jacob FD, Chung W, Weaver KN, Owens JW, Husami A, Chaudhari BP, Stone BS, Burns K, Li R, de Lange IM, Biehler M, Ginglinger E, Gérard B, Stottmann RW, Trimouille A., Free PMC Article

    09/26/2023
    Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

    Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.
    Luciano AK, Korobkina ED, Lyons SP, Haley JA, Fluharty SM, Jung SM, Kettenbach AN, Guertin DA., Free PMC Article

    11/19/2022
    ARF1 haploinsufficiency causes periventricular nodular heterotopia with variable clinical expressivity.

    ARF1 haploinsufficiency causes periventricular nodular heterotopia with variable clinical expressivity.
    Gana S, Casella A, Cociglio S, Tartara E, Rognone E, Giorgio E, Pichiecchio A, Orcesi S, Valente EM.

    08/6/2022
    Cross Talk between ARF1 and RhoA Coordinates the Formation of Cytoskeletal Scaffolds during Chlamydia Infection.

    Cross Talk between ARF1 and RhoA Coordinates the Formation of Cytoskeletal Scaffolds during Chlamydia Infection.
    Haines A, Wesolowski J, Ryan NM, Monteiro-Brás T, Paumet F., Free PMC Article

    02/26/2022
    Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8(+) T cells.

    Plumbagin suppresses non-small cell lung cancer progression through downregulating ARF1 and by elevating CD8(+) T cells.
    Jiang ZB, Xu C, Wang W, Zhang YZ, Huang JM, Xie YJ, Wang QQ, Fan XX, Yao XJ, Xie C, Wang XR, Yan PY, Ma YP, Wu QB, Leung EL.

    02/5/2022
    Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis.

    Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis.
    Cheng J, Lou Y, Jiang K., Free PMC Article

    11/22/2021
    Gbetagamma translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.

    Gβγ translocation to the Golgi apparatus activates ARF1 to spatiotemporally regulate G protein-coupled receptor signaling to MAPK.
    Khater M, Bryant CN, Wu G., Free PMC Article

    09/4/2021
    Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes.

    Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes.
    Sager G, Szul T, Lee E, Kawai R, Presley JF, Sztul E., Free PMC Article

    08/21/2021
    miR-744-5p inhibits cellular proliferation and invasion via targeting ARF1 in epithelial ovarian cancer.

    miR-744-5p inhibits cellular proliferation and invasion via targeting ARF1 in epithelial ovarian cancer.
    Zhao LG, Wang J, Li J, Li QF.

    08/7/2021
    Upregulation of 5'-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor.

    Upregulation of 5'-terminal oligopyrimidine mRNA translation upon loss of the ARF tumor suppressor.
    Cottrell KA, Chiou RC, Weber JD., Free PMC Article

    05/8/2021
    Structural characterization of an Arf dimer interface: molecular mechanism of Arf-dependent membrane scission.

    Structural characterization of an Arf dimer interface: molecular mechanism of Arf-dependent membrane scission.
    Diestelkoetter-Bachert P, Beck R, Reckmann I, Hellwig A, Garcia-Saez A, Zelman-Hopf M, Hanke A, Nunes Alves A, Wade RC, Mayer MP, Wieland F.

    05/8/2021
    LncRNA TP73-AS1 is a novel regulator in cervical cancer via miR-329-3p/ARF1 axis.

    LncRNA TP73-AS1 is a novel regulator in cervical cancer via miR-329-3p/ARF1 axis.
    Xu J, Zhang J.

    02/27/2021
    Hazara Nairovirus Requires COPI Components in both Arf1-Dependent and Arf1-Independent Stages of Its Replication Cycle.

    Hazara Nairovirus Requires COPI Components in both Arf1-Dependent and Arf1-Independent Stages of Its Replication Cycle.
    Fuller J, Álvarez-Rodríguez B, Todd EJAA, Mankouri J, Hewson R, Barr JN., Free PMC Article

    12/5/2020
    The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1.

    The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1.
    Ramos-Miguel A, Barakauskas V, Alamri J, Miyauchi M, Barr AM, Beasley CL, Rosoklija G, Mann JJ, Dwork AJ, Moradian A, Morin GB, Honer WG., Free PMC Article

    09/26/2020
    Mutations in the ARF N terminus that reduced binding also reduced GAP activity. We conclude that PIP2 regulates binding of ASAP1's PH domain to the ARF1 N terminus, which may partially regulate GAP activity.

    Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate.
    Roy NS, Jian X, Soubias O, Zhai P, Hall JR, Dagher JN, Coussens NP, Jenkins LM, Luo R, Akpan IO, Hall MD, Byrd RA, Yohe ME, Randazzo PA., Free PMC Article

    06/13/2020
    Mutants disrupting minor groove recognition of ARF1 SBS affect in vitro binding and reduce STAU1-mediated mRNA decay (SMD) in vivo. Our data thus reveal how STAU1 recognizes minor groove features in dsRNA relevant for target selection

    Staufen1 reads out structure and sequence features in ARF1 dsRNA for target recognition.
    Yadav DK, Zigáčková D, Zlobina M, Klumpler T, Beaumont C, Kubíčková M, Vaňáčová Š, Lukavsky PJ., Free PMC Article

    03/21/2020
    ARF1 regulates the spatial organization of mitochondria in a microtubule-dependent manner.GBF1 and Arf1 interact with Miro2.

    GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.
    Walch L, Pellier E, Leng W, Lakisic G, Gautreau A, Contremoulins V, Verbavatz JM, Jackson CL., Free PMC Article

    12/21/2019
    ARF1 activation status is altered at cold temperatures. Activated ARF1 can prevent cold-induced dispersal of golgin-160.

    Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins.
    Gilbert CE, Sztul E, Machamer CE., Free PMC Article

    02/2/2019
    Coincident with the loss of PICK1 by GBF1-activated ARF1, CDC42 recruitment leads to the activation of IRSp53 and the ARP2/3 complex, resulting in a burst of F-actin polymerisation potentially powering scission.

    Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis.
    Sathe M, Muthukrishnan G, Rae J, Disanza A, Thattai M, Scita G, Parton RG, Mayor S., Free PMC Article

    12/22/2018
    This study suggests that simultaneous blockade of Arf1 and Ras activation in prostate cancer cells is a potential targeted therapeutic strategy for preventing prostate cancer development.

    Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics.
    Lang L, Shay C, Zhao X, Teng Y., Free PMC Article

    06/23/2018
    Silencing of ARF1 impaired RAC1 recruitment to leading edge in neutrophil chemotaxis.

    ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis.
    Mazaki Y, Onodera Y, Higashi T, Horinouchi T, Oikawa T, Sabe H., Free PMC Article

    05/26/2018
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