| USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer. | USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer.
Chang Y, Chen L, Tang J, Chen G, Ji J, Xu M. | 12/5/2023 |
| AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity. | AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity.
Schnoegl D, Hiesinger A, Huntington ND, Gotthardt D. | 11/30/2023 |
| JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation. | JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation.
Zhang D, Pan G, Cheng N, Sun L, Zhou X, Li C, Zhao J. | 03/30/2023 |
| JUND-dependent up-regulation of HMOX1 is associated with cisplatin resistance in muscle-invasive bladder cancer. | JUND-dependent up-regulation of HMOX1 is associated with cisplatin resistance in muscle-invasive bladder cancer.
Peng Y, Chen Y, Chen S, Wang J, Jiang C, Hou W, Xu C. | 02/2/2021 |
| The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR. | The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR.
Singh G, Fritz SE, Seufzer B, Boris-Lawrie K., Free PMC Article | 12/26/2020 |
| LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis. | LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis.
Chen K, Fang H, Xu N. | 10/3/2020 |
| Data indicate the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and suggest structural insight for therapeutic interventions targeting AP-1 proteins. | Activator Protein-1: redox switch controlling structure and DNA-binding.
Yin Z, Machius M, Nestler EJ, Rudenko G., Free PMC Article | 12/2/2017 |
| In T cells, after serum deprivation HBZ induces the expression of Delta JunD isoform. Unlike JunD, Delta JunD induces proliferation and transformation of cells. HBZ bypasses translational control of JunD uORF and favors the expression of Delta JunD. The truncated isoform Delta JunD has a central role in the oncogenic process leading to adult T-cell leukemia . | HBZ-mediated shift of JunD from growth suppressor to tumor promoter in leukemic cells by inhibition of ribosomal protein S25 expression.
Terol M, Gazon H, Lemasson I, Duc-Dodon M, Barbeau B, Césaire R, Mesnard JM, Péloponèse JM Jr. | 10/28/2017 |
| MiR-663a suppresses proliferation and invasion by targeting AP-1 component JunD in non-small cell lung cancer cells. | MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD.
Zhang Y, Xu X, Zhang M, Wang X, Bai X, Li H, Kan L, Zhou Y, Niu H, He P., Free PMC Article | 10/7/2017 |
| studies showed that down-regulation of JunD in response to TGF-beta treatment is mediated via the proteasomal degradation pathway. | JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation.
Millena AC, Vo BT, Khan SA., Free PMC Article | 05/13/2017 |
| CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. | CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
Juilland M, Gonzalez M, Erdmann T, Banz Y, Jevnikar Z, Hailfinger S, Tzankov A, Grau M, Lenz G, Novak U, Thome M., Free PMC Article | 08/20/2016 |
| recombinant SERPINE2 induced a clear inhibition of MMP-13 expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1/2, NF-kappaB and AP-1 | SERPINE2 Inhibits IL-1α-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-κB/AP-1 Pathways.
Santoro A, Conde J, Scotece M, Abella V, Lois A, Lopez V, Pino J, Gomez R, Gomez-Reino JJ, Gualillo O., Free PMC Article | 05/21/2016 |
| miR-494 is a novel regulator of HNPC apoptosis induced by TNF-alpha | MicroRNA-494 inhibition protects nucleus pulposus cells from TNF-α-induced apoptosis by targeting JunD.
Wang T, Li P, Ma X, Tian P, Han C, Zang J, Kong J, Yan H. | 04/9/2016 |
| JunD activates miR-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD | JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.
Zou T, Rao JN, Liu L, Xiao L, Chung HK, Li Y, Chen G, Gorospe M, Wang JY., Free PMC Article | 07/25/2015 |
| Binding of specific AP-1 factors, we found JunD associated with the LILRB1 distal promoter. | The AP-1 transcription factor JunD activates the leukocyte immunoglobulin-like receptor 1 distal promoter.
Davidson CL, Cameron LE, Burshtyn DN. | 09/13/2014 |
| Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3- JUND expression. | A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.
Wang CC, Bajikar SS, Jamal L, Atkins KA, Janes KA., Free PMC Article | 06/9/2014 |
| BAG3 stabilized JunD mRNA. | BAG3 is upregulated by c-Jun and stabilizes JunD.
Li C, Li S, Kong DH, Meng X, Zong ZH, Liu BQ, Guan Y, Du ZX, Wang HQ. | 03/1/2014 |
| Jun proteins (pc-Jun and JunD) influence carcinogenesis and tumour progression, suggesting a significant role as prognostic predictors in human ovarian carcinoma. | The prognostic significance of Jun transcription factors in ovarian cancer.
Eckhoff K, Flurschütz R, Trillsch F, Mahner S, Jänicke F, Milde-Langosch K. | 11/16/2013 |
| This genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor | Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d'etude des Tumeurs Endocrines (GTE) cohort study.
Thevenon J, Bourredjem A, Faivre L, Cardot-Bauters C, Calender A, Murat A, Giraud S, Niccoli P, Odou MF, Borson-Chazot F, Barlier A, Lombard-Bohas C, Clauser E, Tabarin A, Parfait B, Chabre O, Castermans E, Beckers A, Ruszniewski P, Le Bras M, Delemer B, Bouchard P, Guilhem I, Rohmer V, Goichot B, Caron P, Baudin E, Chanson P, Groussin L, Du Boullay H, Weryha G, Lecomte P, Penfornis A, Bihan H, Archambeaud F, Kerlan V, Duron F, Kuhn JM, Vergès B, Rodier M, Renard M, Sadoul JL, Binquet C, Goudet P. | 11/2/2013 |
| HTLV-1 bZIP factor(hbz) requires cellular JunD to upregulate HTLV-1 antisense transcription from the 3' long terminal repeat. | Human T-cell leukemia virus type 1 (HTLV-1) bZIP factor requires cellular transcription factor JunD to upregulate HTLV-1 antisense transcription from the 3' long terminal repeat.
Gazon H, Lemasson I, Polakowski N, Césaire R, Matsuoka M, Barbeau B, Mesnard JM, Peloponese JM Jr., Free PMC Article | 11/17/2012 |
| results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs | Expression and function of FRA2/JUND in cutaneous T-cell lymphomas.
Nakayama T, Higuchi T, Oiso N, Kawada A, Yoshie O. | 05/26/2012 |
| crystal structures of human menin in its free form and in complexes with MLL1 or with JUND, or with an MLL1-LEDGF heterodimer | The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M., Free PMC Article | 03/31/2012 |
| Apoptosis induction by dominant negative JunD is due to induction of growth arrest and DNA damage inducible proteins (GADD) 45 alpha and 45 gamma proteins. | JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer.
Zerbini LF, de Vasconcellos JF, Czibere A, Wang Y, Paccez JD, Gu X, Zhou JR, Libermann TA., Free PMC Article | 12/17/2011 |
| CDK4-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation | CDK-mediated regulation of cell functions via c-Jun phosphorylation and AP-1 activation.
Vanden Bush TJ, Bishop GA., Free PMC Article | 12/3/2011 |
| JunD mediates, whereas c-Jun modulates, prostaglandin E2 activation of aromatase promoters | JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters.
Chen D, Reierstad S, Fang F, Bulun SE., Free PMC Article | 10/1/2011 |