| A pleiotropic recurrent dominant ITPR3 variant causes a complex multisystemic disease. | A pleiotropic recurrent dominant ITPR3 variant causes a complex multisystemic disease.
Molitor A, Lederle A, Radosavljevic M, Sapuru V, Zavorka Thomas ME, Yang J, Shirin M, Collin-Bund V, Jerabkova-Roda K, Miao Z, Bernard A, Rolli V, Grenot P, Castro CN, Rosenzwajg M, Lewis EG, Person R, Esperón-Moldes US, Kaare M, Nokelainen PT, Batzir NA, Hoffer GZ, Paul N, Stemmelen T, Naegely L, Hanauer A, Bibi-Triki S, Grün S, Jung S, Busnelli I, Tripolszki K, Al-Ali R, Ordonez N, Bauer P, Song E, Zajo K, Partida-Sanchez S, Robledo-Avila F, Kumanovics A, Louzoun Y, Hirschler A, Pichot A, Toker O, Mejía CAM, Parvaneh N, Knapp E, Hersh JH, Kenney H, Delmonte OM, Notarangelo LD, Goetz JG, Kahwash SB, Carapito C, Bajwa RPS, Thomas C, Ehl S, Isidor B, Carapito R, Abraham RS, Hite RK, Marcus N, Bertoli-Avella A, Bahram S., Free PMC Article | 11/6/2024 |
| Disrupted Ca[2+] homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects. | Disrupted Ca(2+) homeostasis and immunodeficiency in patients with functional IP(3) receptor subtype 3 defects.
Neumann J, Van Nieuwenhove E, Terry LE, Staels F, Knebel TR, Welkenhuyzen K, Ahmadzadeh K, Baker MR, Gerbaux M, Willemsen M, Barber JS, Serysheva II, De Waele L, Vermeulen F, Schlenner S, Meyts I, Yule DI, Bultynck G, Schrijvers R, Humblet-Baron S, Liston A., Free PMC Article | 03/9/2023 |
| Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population. | Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.
Chen J, Zhou J, Jiang Y, Wang Y, Chen C, Jiang T, Du J. | 02/11/2023 |
| Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is overexpressed in cholangiocarcinoma and its expression correlates with S100 calcium-binding protein A4 (S100A4). | Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is overexpressed in cholangiocarcinoma and its expression correlates with S100 calcium-binding protein A4 (S100A4).
Rodrigues MA, Gomes DA, Cosme AL, Sanches MD, Resende V, Cassali GD., Free PMC Article | 03/19/2022 |
| ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-kB/CD44 pathway in urinary bladder carcinoma. | ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.
Zhang M, Wang L, Yue Y, Zhang L, Liu T, Jing M, Liang X, Ma M, Xu S, Wang K, Wang X, Fan J., Free PMC Article | 10/16/2021 |
| Dominant mutations in ITPR3 cause Charcot-Marie-Tooth disease. | Dominant mutations in ITPR3 cause Charcot-Marie-Tooth disease.
Rönkkö J, Molchanova S, Revah-Politi A, Pereira EM, Auranen M, Toppila J, Kvist J, Ludwig A, Neumann J, Bultynck G, Humblet-Baron S, Liston A, Paetau A, Rivera C, Harms MB, Tyynismaa H, Ylikallio E., Free PMC Article | 08/21/2021 |
| Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients. | Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients.
Wu Y, Liu Z, Tang D, Liu H, Luo S, Stinchcombe TE, Glass C, Su L, Lin L, Christiani DC, Wang Q, Wei Q., Free PMC Article | 08/7/2021 |
| STIM1 Deficiency Leads to Specific Down-Regulation of ITPR3 in SH-SY5Y Cells. | STIM1 Deficiency Leads to Specific Down-Regulation of ITPR3 in SH-SY5Y Cells.
Pascual-Caro C, Orantos-Aguilera Y, Sanchez-Lopez I, de Juan-Sanz J, Parys JB, Area-Gomez E, Pozo-Guisado E, Martin-Romero FJ., Free PMC Article | 03/6/2021 |
| Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells. | Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.
Yue L, Wang L, Du Y, Zhang W, Hamada K, Matsumoto Y, Jin X, Zhou Y, Mikoshiba K, Gill DL, Han S, Wang Y., Free PMC Article | 02/13/2021 |
| Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist. | Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.
Azumaya CM, Linton EA, Risener CJ, Nakagawa T, Karakas E., Free PMC Article | 10/24/2020 |
| These results suggest that STAT3-mediated IP3R3 downregulation in the ER crucially contributes to its anti-apoptotic functions via modulation of Ca(2+) fluxes. | STAT3 localizes to the ER, acting as a gatekeeper for ER-mitochondrion Ca(2+) fluxes and apoptotic responses.
Avalle L, Camporeale A, Morciano G, Caroccia N, Ghetti E, Orecchia V, Viavattene D, Giorgi C, Pinton P, Poli V., Free PMC Article | 07/11/2020 |
| expression was decreased or absent in cholangiocytes from patients with cholestasis of sepsis and from those with severe alcoholic hepatitis | Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes.
Franca A, Carlos Melo Lima Filho A, Guerra MT, Weerachayaphorn J, Loiola Dos Santos M, Njei B, Robert M, Xavier Lima C, Vieira Teixeira Vidigal P, Banales JM, Ananthanarayanam M, Leite MF, Nathanson MH., Free PMC Article | 05/23/2020 |
| Loss of DJ-1 disrupted the IP3R3-Grp75-VDAC1 complex and led to reduced endoplasmic reticulum-mitochondria association and disturbed function of mitochondria-associated membrane and mitochondria. | DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1.
Liu Y, Ma X, Fujioka H, Liu J, Chen S, Zhu X., Free PMC Article | 05/2/2020 |
| shown a novel association between hypermethylation of the distal intergenic region, located upstream of ITPR3, and delayed cerebral ischemia occurrence in patients with subarachnoid hemorrhage. | Correlation Between Altered DNA Methylation of Intergenic Regions of ITPR3 and Development of Delayed Cerebral Ischemia in Patients with Subarachnoid Hemorrhage.
Kim BJ, Kim Y, Hong EP, Jeon JP, Yang JS, Choi HJ, Kang SH, Cho YJ. | 01/25/2020 |
| the viral protein NS5A forms a trimeric complex with IP3R3 and FBXL2, unmasking IP3R3's degron in the absence of inositol 1,4,5-trisphosphate (IP3) stimulation. | NS5A Promotes Constitutive Degradation of IP3R3 to Counteract Apoptosis Induced by Hepatitis C Virus.
Kuchay S, Saeed M, Giorgi C, Li J, Hoffmann HH, Pinton P, Rice CM, Pagano M., Free PMC Article | 11/16/2019 |
| Expression of the type 3 InsP3 receptor is a final common event in the development of hepatocellular carcinoma. | Expression of the type 3 InsP(3) receptor is a final common event in the development of hepatocellular carcinoma.
Guerra MT, Florentino RM, Franca A, Lima Filho AC, Dos Santos ML, Fonseca RC, Lemos FO, Fonseca MC, Kruglov E, Mennone A, Njei B, Gibson J, Guan F, Cheng YC, Ananthanarayanan M, Gu J, Jiang J, Zhao H, Lima CX, Vidigal PT, Oliveira AG, Nathanson MH, Leite MF., Free PMC Article | 09/28/2019 |
| TOM70, but not TOM20, clusters in distinct OMM foci, frequently overlapping with sites in which the endoplasmic reticulum (ER) contacts mitochondria. Functionally, TOM70 depletion specifically impairs inositol trisphosphates (IP3)-linked ER to mitochondria Ca(2+) transfer. This phenomenon is dependent on the capacity of TOM70 to interact with IP3-receptors and favor their functional recruitment close to mitochondria. | TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca(2+) Transfer.
Filadi R, Leal NS, Schreiner B, Rossi A, Dentoni G, Pinho CM, Wiehager B, Cieri D, Calì T, Pizzo P, Ankarcrona M. | 07/6/2019 |
| Data demonstrated that IP3R3 is able to modulate intracellular Ca(2+) availability and to coordinate the remodeling of profilin cytoskeleton organization through the ARHGAP18/RhoA/mDia1/FAK pathway. | IP(3)R3 silencing induced actin cytoskeletal reorganization through ARHGAP18/RhoA/mDia1/FAK pathway in breast cancer cell lines.
Vautrin-Glabik A, Botia B, Kischel P, Ouadid-Ahidouch H, Rodat-Despoix L. | 12/1/2018 |
| Suggest that AT haplotype in the ITPR3 gene may serve as a potential marker for genetic susceptibility to cervical squamous cell carcinoma risk in Taiwanese women. | ITPR3 gene haplotype is associated with cervical squamous cell carcinoma risk in Taiwanese women.
Yang YC, Chang TY, Chen TC, Lin WS, Chang SC, Lee YJ., Free PMC Article | 02/24/2018 |
| BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation | BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation.
Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M., Free PMC Article | 11/11/2017 |
| PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth | PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth.
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, Florens L, Washburn MP, Collazo-Lorduy A, Castillo-Martin M, Cordon-Cardo C, Sebti SM, Pinton P, Pagano M., Free PMC Article | 11/11/2017 |
| Studies indicate that the ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca(2+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR). | Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.
Santulli G, Marks AR. | 07/16/2016 |
| the ability to generate tetramers with defined wild type and mutant subunits will be useful in probing fundamental questions relating to IP3Rs (R1, R2, R3) structure and function. | Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.
Chandrasekhar R, Alzayady KJ, Yule DI., Free PMC Article | 02/27/2016 |
| The transcription factor NRF2 binds to the promoter of ITPR3 to inhibit its expression in cholangiocytes, leading to reduced calcium signaling and bile duct secretion. | Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes.
Weerachayaphorn J, Amaya MJ, Spirli C, Chansela P, Mitchell-Richards KA, Ananthanarayanan M, Nathanson MH., Free PMC Article | 10/3/2015 |
| miR-506 is a regulator of InsP3R3 expression and InsP3R3-mediated Ca2+ signaling and secretion. | Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506.
Ananthanarayanan M, Banales JM, Guerra MT, Spirli C, Munoz-Garrido P, Mitchell-Richards K, Tafur D, Saez E, Nathanson MH., Free PMC Article | 04/11/2015 |