| Cryo-EM structure of I domain-containing integrin alphaEbeta7. | Cryo-EM structure of I domain-containing integrin αEβ7.
Akasaka H, Sato D, Shihoya W, Nureki O, Kise Y. | 06/14/2024 |
| Expression of integrin beta-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics. | Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics.
Roy Choudhury S, Byrum SD, Alkam D, Ashby C, Zhan F, Tackett AJ, Van Rhee F., Free PMC Article | 02/11/2023 |
| Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis. | Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.
Xu T, Liu J, Xia Y, Wang Z, Li X, Gao Q., Free PMC Article | 12/4/2021 |
| The association of alpha4beta7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies. | The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies.
Martin AR, Patel EU, Kirby C, Astemborski J, Kirk GD, Mehta SH, Marshall K, Janes H, Clayton A, Corey L, Hammer SM, Sobieszczyk ME, Arthos J, Cicala C, Redd AD, Quinn TC., Free PMC Article | 08/28/2021 |
| Expression of activated integrin beta7 in multiple myeloma patients. | Expression of activated integrin β7 in multiple myeloma patients.
Hosen N, Yoshihara S, Takamatsu H, Ri M, Nagata Y, Kosugi H, Shimomura Y, Hanamura I, Fuji S, Minauchi K, Kuroda J, Suzuki R, Nishimura N, Uoshima N, Nakamae H, Kawano Y, Mizuno I, Gomyo H, Suzuki K, Ozaki S, Nakamura S, Imai Y, Kizaki M, Negoro E, Handa H, Iida S. | 07/3/2021 |
| The V2 loop of HIV gp120 delivers costimulatory signals to CD4(+) T cells through Integrin alpha4beta7 and promotes cellular activation and infection. | The V2 loop of HIV gp120 delivers costimulatory signals to CD4(+) T cells through Integrin α(4)β(7) and promotes cellular activation and infection.
Goes LR, Sajani A, Sivro A, Olowojesiku R, Ray JC, Perrone I, Yolitz J, Girard A, Leyre L, Wibmer CK, Morris L, Gorini G, Franchini G, Mason RD, Roederer M, Mehandru S, Soares MA, Cicala C, Fauci AS, Arthos J., Free PMC Article | 02/20/2021 |
| Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome. | Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.
Pilarowski GO, Cazares T, Zhang L, Benjamin JS, Liu K, Jagannathan S, Mousa N, Kasten J, Barski A, Lindsley AW, Bjornsson HT. | 12/5/2020 |
| Racial differences in alpha4beta7 expression on CD4+ T cells of HIV-negative men and women who inject drugs. | Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs.
Martin AR, Sivro A, Packman ZR, Patel EU, Goes LR, McKinnon LR, Astemborski J, Kirk GD, Mehta SH, Cicala C, Arthos J, Redd AD, Quinn TC., Free PMC Article | 10/24/2020 |
| Increased frequencies of pre-HIV alpha4beta7(+) CD4(+) T cells were also associated with higher postinfection expression of lipopolysaccharide binding protein, a microbial translocation marker, suggestive of more extensive gut damage. | Integrin α(4)β(7) expression on peripheral blood CD4(+) T cells predicts HIV acquisition and disease progression outcomes.
Sivro A, Schuetz A, Sheward D, Joag V, Yegorov S, Liebenberg LJ, Yende-Zuma N, Stalker A, Mwatelah RS, Selhorst P, Garrett N, Samsunder N, Balgobin A, Nawaz F, Cicala C, Arthos J, Fauci AS, Anzala AO, Kimani J, Bagaya BS, Kiwanuka N, Williamson C, Kaul R, Passmore JS, Phanuphak N, Ananworanich J, Ansari A, Abdool Karim Q, Abdool Karim SS, McKinnon LR, CAPRISA004 and RV254 study groups., Free PMC Article | 09/21/2019 |
| Transmission of integrin beta7 transmembrane domain topology enables gut lymphoid tissue development. | Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.
Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH., Free PMC Article | 03/23/2019 |
| AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD. | Blockade of αEβ7 integrin suppresses accumulation of CD8(+) and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.
Zundler S, Schillinger D, Fischer A, Atreya R, López-Posadas R, Watson A, Neufert C, Atreya I, Neurath MF. | 10/21/2017 |
| gut-homing alpha4beta7 CD4(+) T cells and their functional subsets were profoundly depleted during acute HIV-1 infection. | Preferential loss of gut-homing α4β7 CD4(+) T cells and their circulating functional subsets in acute HIV-1 infection.
Lu X, Li Z, Li Q, Jiao Y, Ji Y, Zhang H, Liu Z, Li W, Wu H., Free PMC Article | 07/15/2017 |
| CCR9 and Integrin-beta7 expression has a differential effect on graft fate during acute graft-versus-host disease (GVHD) of the liver depending on the GVHD target tissue. | Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver.
Schreder A, Moschovakis GL, Halle S, Schlue J, Lee CW, Schippers A, David S, Bernhardt G, Ganser A, Pabst O, Förster R, Koenecke C. | 08/20/2016 |
| Collectively, these data suggest a role for alpha4beta7 integrin in HIV infection that is influenced by both viral and host factors including the sequence of the HIV gp120 alpha4beta7 binding motif, the cytokine milieu and bacterial vaginosis in the genital tract. | South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.
Richardson SI, Gray ES, Mkhize NN, Sheward DJ, Lambson BE, Wibmer CK, Masson L, Werner L, Garrett N, Passmore JA, Karim QA, Karim SS, Williamson C, Moore PL, Morris L., Free PMC Article | 03/26/2016 |
| HIV-1 virions and many gp120s lack detectable alpha4beta7 binding activity. | Envelope glycoprotein binding to the integrin α4β7 is not a general property of most HIV-1 strains.
Perez LG, Chen H, Liao HX, Montefiori DC., Free PMC Article | 01/24/2015 |
| circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b, CD18, CD29, and ITGB7, and the adhesion molecule CD323. | Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations.
Riches JC, O'Donovan CJ, Kingdon SJ, McClanahan F, Clear AJ, Neuberg DS, Werner L, Croce CM, Ramsay AG, Rassenti LZ, Kipps TJ, Gribben JG., Free PMC Article | 09/6/2014 |
| Disruption of the hydrophobic contacts induces the active conformation of integrin alpha 4 beta 7. | The hydrophobic contacts between the center of the βI domain and the α1/α7 helices are crucial for the low-affinity state of integrin α4 β7.
Liu J, Fu T, Peng B, Sun H, Chu H, Li G, Chen J. | 09/6/2014 |
| Two conserved disulfide bonds located at integrin alpha4C589-C594 and beta7C494-C526 activated alpha4beta7. | Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇.
Zhang K, Pan Y, Qi J, Yue J, Zhang M, Xu C, Li G, Chen J. | 06/7/2014 |
| Only rotavirus specific CD4 T cells expressed intestinal homing receptors alpha4beta7 and CCR9. | Circulating human rotavirus specific CD4 T cells identified with a class II tetramer express the intestinal homing receptors α4β7 and CCR9.
Parra M, Herrera D, Calvo-Calle JM, Stern LJ, Parra-López CA, Butcher E, Franco M, Angel J., Free PMC Article | 05/31/2014 |
| Data indicate that signaling by HIV-1 gp120 through integrin alpha4beta7 resulted in increased expression of the immunosuppressive cytokine TGF-beta1 and FcRL4. | The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.
Jelicic K, Cimbro R, Nawaz F, Huang da W, Zheng X, Yang J, Lempicki RA, Pascuccio M, Van Ryk D, Schwing C, Hiatt J, Okwara N, Wei D, Roby G, David A, Hwang IY, Kehrl JH, Arthos J, Cicala C, Fauci AS., Free PMC Article | 01/25/2014 |
| analysis of the molecular basis for alpha4beta7-mediated rolling cell adhesion and a novel regulatory element of integrin affinity and signaling | The unique disulfide bond-stabilized W1 β4-β1 loop in the α4 β-propeller domain regulates integrin α4β7 affinity and signaling.
Yue J, Pan Y, Sun L, Zhang K, Liu J, Lu L, Chen J., Free PMC Article | 08/10/2013 |
| Integrin alpha4beta7 binds gp120 but does not mediate HIV envelope-induced death signaling. | The α4β7 integrin binds HIV envelope but does not mediate bystander killing of γδ T cells.
Li H, Pauza CD. | 10/6/2012 |
| Data suggest that monoclonal antibody J19 is a potentially powerful tool for both studies on alpha(4)beta(7) activation mechanism and development of novel therapeutics targeting the activated lymphocyte expressing high affinity alpha(4)beta(7). | Identification, characterization, and epitope mapping of human monoclonal antibody J19 that specifically recognizes activated integrin α4β7.
Qi J, Zhang K, Zhang Q, Sun Y, Fu T, Li G, Chen J., Free PMC Article | 08/4/2012 |
| Consistent with structural predictions, strain increases beta-integrin binding to FLNA, whereas it causes FilGAP to dissociate from FLNA, providing a direct and specific molecular basis for cellular mechanotransduction | Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP., Free PMC Article | 01/28/2012 |
| a role for integrin-beta7 in MM-cell adhesion, migration, and BM homing, and pave the way for a novel therapeutic approach targeting this molecule. | Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.
Neri P, Ren L, Azab AK, Brentnall M, Gratton K, Klimowicz AC, Lin C, Duggan P, Tassone P, Mansoor A, Stewart DA, Boise LH, Ghobrial IM, Bahlis NJ., Free PMC Article | 08/13/2011 |