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    IL16 interleukin 16 [ Homo sapiens (human) ]

    Gene ID: 3603, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer.

    Association of the Single Nucleotide Polymorphisms rs11556218, rs4778889, rs4072111, and rs1131445 of the Interleukin-16 Gene with Ovarian Cancer.
    Watrowski R, Schuster E, Van Gorp T, Hofstetter G, Fischer MB, Mahner S, Polterauer S, Zeillinger R, Obermayr E., Free PMC Article

    10/23/2024
    Enhanced interleukin-16-CD4 signaling in CD3 T cell mediates neuropathic pain via activating astrocytes in female mice.

    Enhanced interleukin-16-CD4 signaling in CD3 T cell mediates neuropathic pain via activating astrocytes in female mice.
    Zhu X, Li X, Liu S, Zhao YH, Liu XR, Liu XY, Yao R, Tian L, Liu XQ, Meng F, Liang L.

    08/29/2024
    Genetic Association of Interleukin 16 Gene Polymorphisms (rs11556218 & rs4778889) with Type 1 Diabetes in Egyptian Children: A Case-Control Study.

    Genetic Association of Interleukin 16 Gene Polymorphisms (rs11556218 & rs4778889) with Type 1 Diabetes in Egyptian Children: A Case-Control Study.
    Ali YBM, Saed MM, Abdel-Hakem NE, Hussein MAEA, El-Shahat M.

    08/23/2024
    Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor.

    Interleukin-16 is increased in dialysis patients but is not a cardiovascular risk factor.
    Brösecke F, Pfau A, Ermer T, Dein Terra Mota Ribeiro AB, Rubenbauer L, Rao VS, Burlein S, Genser B, Reichel M, Aronson PS, Coca S, Knauf F., Free PMC Article

    08/23/2024
    Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro.

    Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro.
    Reyes-Farias M, Fernández-García P, Corrales P, González L, Soria-Gondek A, Martínez E, Pellitero S, Tarascó J, Moreno P, Sumoy L, Medina-Gómez G, Sánchez-Infantes D, Herrero L., Free PMC Article

    04/2/2024
    Mycobacterium tuberculosis hijacks host macrophages-derived interleukin 16 to block phagolysosome maturation for enhancing intracellular growth.

    Mycobacterium tuberculosis hijacks host macrophages-derived interleukin 16 to block phagolysosome maturation for enhancing intracellular growth.
    Su H, Weng S, Luo L, Sun Q, Lin T, Ma H, He Y, Wu J, Wang H, Zhang W, Xu Y., Free PMC Article

    03/11/2024
    Association of IL-6 rs1800795, but not TNF-alpha rs1800629, and IL-1beta rs16944 polymorphisms' genotypes with recovery of ischemic stroke patients following thrombolysis.

    Association of IL-6 rs1800795, but not TNF-α rs1800629, and IL-1β rs16944 polymorphisms' genotypes with recovery of ischemic stroke patients following thrombolysis.
    Dusanovic Pjevic M, Vojvodic L, Grk M, Todorovic J, Maksimovic N, Rasic M, Perovic D, Damnjanovic T, Trickovic J, Kacar K, Jekic B.

    01/8/2024
    The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and Helicobacter Pylori Infection to Gastric Cancer.

    The Significant Contribution of Interleukin-16 Genotypes, Smoking, Alcohol Drinking, and Helicobacter Pylori Infection to Gastric Cancer.
    Fu CK, Mong MC, Tzeng HE, Yang MD, Chen JC, Hsia TC, Hsia NY, Tsai CW, Chang WS, Chen CP, Bau DT., Free PMC Article

    01/4/2024
    Elevated expression of interleukin 16 in chronic lymphocytic leukemia is associated with disease burden and abnormal immune microenvironment.

    Elevated expression of interleukin 16 in chronic lymphocytic leukemia is associated with disease burden and abnormal immune microenvironment.
    Wu X, Thisdelle J, Hou S, Fajardo-Despaigne JE, Gibson SB, Johnston JB, Dawe DE, Banerji V, Marshall AJ.

    08/2/2023
    The relationship of promoter methylation of calcium voltage-gated channel alpha 1 and interleukin-16 to primary osteoarthritis.

    The relationship of promoter methylation of calcium voltage-gated channel alpha 1 and interleukin-16 to primary osteoarthritis.
    Kehribar L, Betul Celik Z, Yalcin Kehribar D, Eseoglu I, Gunaydin C, Aydin M.

    06/2/2023
    Interleukin-16 genetic polymorphisms in Guangxi Chinese with hepatitis B virus-related liver cirrhosis.

    Interleukin-16 genetic polymorphisms in Guangxi Chinese with hepatitis B virus-related liver cirrhosis.
    Zhang X, Tang W, Qin X, Li S, Liang D.

    05/26/2023
    Serum concentrations of IL-16 and its genetic polymorphism rs4778889 affect the susceptibility and severity of endometriosis in Nigerian women.

    Serum concentrations of IL-16 and its genetic polymorphism rs4778889 affect the susceptibility and severity of endometriosis in Nigerian women.
    Babah OA, Ojewunmi OO, Onwuamah CK, Udenze IC, Osuntoki AA, Afolabi BB., Free PMC Article

    05/18/2023
    IL16 and factor V gene variations are associated with asparaginase-related thrombosis in childhood acute lymphoblastic leukemia patients.

    IL16 and factor V gene variations are associated with asparaginase-related thrombosis in childhood acute lymphoblastic leukemia patients.
    Mootoosamy C, Kondyli M, Serfaty SA, Tremblay DÉ, Gagné V, Ribère M, Laverdière C, Leclerc JM, Sinnett D, Tran TH, Krajinovic M.

    03/30/2023
    Interleukin (IL) 16: a candidate urinary biomarker for proliferative lupus nephritis.

    Interleukin (IL) 16: a candidate urinary biomarker for proliferative lupus nephritis.
    Häyry A, Faustini F, Zickert A, Larsson A, Niewold TB, Svenungsson E, Oke V, Gunnarsson I., Free PMC Article

    10/1/2022
    Association of a miRNA-binding site polymorphism in IL-16 gene with disease risk and clinical characteristics of rheumatoid arthritis and systemic lupus erythematosus.

    Association of a miRNA-binding site polymorphism in IL-16 gene with disease risk and clinical characteristics of rheumatoid arthritis and systemic lupus erythematosus.
    Zeinalzadeh S, Kheradmand N, Rasouli G, Esmaeilzadeh E, Pakzad B, Behroozi J, Chamanara M, Zoshk MY, Ehtesham N, Sabet MN.

    06/18/2022
    Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology.

    Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology.
    Ramirez J, Bitterman P, Basu S, Barua A., Free PMC Article

    05/7/2022
    MicroRNA-96 is Downregulated in Sepsis Neonates and Attenuates LPSInduced Inflammatory Response by Inhibiting IL-16 in Monocytes.

    MicroRNA-96 is Downregulated in Sepsis Neonates and Attenuates LPSInduced Inflammatory Response by Inhibiting IL-16 in Monocytes.
    Zhang C, Li X, Liu N, Feng Z, Zhang C.

    03/26/2022
    Association of Sarcopenia and Expression of Interleukin-16 in Gastric Cancer Survival.

    Association of Sarcopenia and Expression of Interleukin-16 in Gastric Cancer Survival.
    Xiong J, Hu H, Kang W, Shao X, Li Y, Jin P, Tian Y., Free PMC Article

    03/5/2022
    Hsa_circ_0001326 regulates proliferation, migration, invasion, and EMT of HTR-8/SVneo cells via increasing IL16 expression.

    Hsa_circ_0001326 regulates proliferation, migration, invasion, and EMT of HTR-8/SVneo cells via increasing IL16 expression.
    Liu Y, Ma X, Liu Y.

    03/5/2022
    microRNA-128-3p inhibits CD4+ regulatory T cells enrichment by targeting interleukin 16 in gastric cancer.

    microRNA-128-3p inhibits CD4+ regulatory T cells enrichment by targeting interleukin 16 in gastric cancer.
    Fang W, Shi C, Wang Y, Song J, Zhang L., Free PMC Article

    02/26/2022
    Identification of interleukin-16 production on tumor aggravation in hepatocellular carcinoma by a proteomics approach.

    Identification of interleukin-16 production on tumor aggravation in hepatocellular carcinoma by a proteomics approach.
    Takeba Y, Ohta Y, Ootaki M, Kobayashi T, Kida K, Watanabe M, Koizumi S, Otsubo T, Iiri T, Matsumoto N.

    12/25/2021
    [Expression and clinical significance of interleukin-16 in patients with primary biliary cholangitis].

    [Expression and clinical significance of interleukin-16 in patients with primary biliary cholangitis].
    Liu QY, Li Y, Ma X, Tang RQ.

    07/24/2021
    Proteome study of cutaneous lupus erythematosus (CLE) and dermatomyositis skin lesions reveals IL-16 is differentially upregulated in CLE.

    Proteome study of cutaneous lupus erythematosus (CLE) and dermatomyositis skin lesions reveals IL-16 is differentially upregulated in CLE.
    Niewold TB, Meves A, Lehman JS, Popovic-Silwerfeldt K, Häyry A, Söderlund-Matell T, Charlesworth CM, Madden B, Lundberg IE, Wahren-Herlenius M, Svenungsson E, Oke V., Free PMC Article

    07/10/2021
    Interleukin 6, interleukin 17, disease-related and contextual factor association with depression, and its severity in patients with rheumatoid arthritis.

    Interleukin 6, interleukin 17, disease-related and contextual factor association with depression, and its severity in patients with rheumatoid arthritis.
    Albeltagy ES, Elaziz SYA, Abozaid SY, El Zomor HM, Elhamed SSA.

    07/10/2021
    Association of IL-16 gene polymorphisms with sporadic Parkinson's disease in a Han Chinese population.

    Association of IL-16 gene polymorphisms with sporadic Parkinson's disease in a Han Chinese population.
    Zhang X, Xue L, Sun X, Jin J, Bai X, Xie A.

    04/24/2021
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