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    CXCL8 C-X-C motif chemokine ligand 8 [ Homo sapiens (human) ]

    Gene ID: 3576, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Comparative Bindings of Glycosaminoglycans with CXCL8 Monomer and Dimer: Insights from Conformational Dynamics and Kinetics of Hydrogen Bonds.

    Comparative Bindings of Glycosaminoglycans with CXCL8 Monomer and Dimer: Insights from Conformational Dynamics and Kinetics of Hydrogen Bonds.
    Dhurua S, Maity S, Maity B, Jana M.

    11/1/2024
    Diagnostic utility of sortilin & other biomarkers in the diagnosis of carotid & coronary atherosclerosis in individuals with arterial hypertension.

    Diagnostic utility of sortilin & other biomarkers in the diagnosis of carotid & coronary atherosclerosis in individuals with arterial hypertension.
    Vukolova Y, Gubareva I, Galati G, Germanova O., Free PMC Article

    10/18/2024
    IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-kappaB-RhoA signal pathway.

    IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-κB-RhoA signal pathway.
    Si W, Liu J, Wang Y, Mao Y, Zhang Y, Xu S, Guo K, Zhang Y, Hu Y, Zhang F.

    10/17/2024
    Association of IL4RA and IL-8 polymorphism in predicting susceptibility to tuberculosis.

    Association of IL4RA and IL-8 polymorphism in predicting susceptibility to tuberculosis.
    K J, Joshi JL, Kansal H, Chopra V, Garg K, Girdhar N, Sharma K, Deshwal R, Sharma S.

    09/25/2024
    linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability.

    linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability.
    O'Reilly ME, Ho S, Coronel J, Zhu L, Liu W, Xue C, Kim E, Cynn E, Matias CV, Soni RK, Wang C, Ionita-Laza I, Bauer RC, Ross L, Zhang Y, Corvera S, Fried SK, Reilly MP., Free PMC Article

    09/25/2024
    Extracellular Vesicles Induce Nuclear Factor-kappaB Activation and Interleukin-8 Synthesis through miRNA-191-5p Contributing to Inflammatory Processes: Potential Implications in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

    Extracellular Vesicles Induce Nuclear Factor-κB Activation and Interleukin-8 Synthesis through miRNA-191-5p Contributing to Inflammatory Processes: Potential Implications in the Pathogenesis of Chronic Obstructive Pulmonary Disease.
    Carpi S, Polini B, Nieri D, Doccini S, Conti M, Bazzan E, Pagnini M, Santorelli FM, Cecchini M, Nieri P, Celi A, Neri T., Free PMC Article

    09/11/2024
    Discriminatory performance of the pulpal inflammatory biomarkers; Interleukin-8 and TNF-alpha in patients with symptoms indicative of reversible and irreversible pulpitis: A diagnostic accuracy study.

    Discriminatory performance of the pulpal inflammatory biomarkers; Interleukin-8 and TNF-α in patients with symptoms indicative of reversible and irreversible pulpitis: A diagnostic accuracy study.
    Nawal RR, Yadav S, Duncan HF, Talwar S, Kaushik A, Singh VK, Koner BC.

    08/15/2024
    IL-8 Induces Neutrophil Extracellular Trap Formation in Severe Thermal Injury.

    IL-8 Induces Neutrophil Extracellular Trap Formation in Severe Thermal Injury.
    Asiri A, Hazeldine J, Moiemen N, Harrison P., Free PMC Article

    08/9/2024
    CCL8 mediates crosstalk between endothelial colony forming cells and triple-negative breast cancer cells through IL-8, aggravating invasion and tumorigenicity.

    CCL8 mediates crosstalk between endothelial colony forming cells and triple-negative breast cancer cells through IL-8, aggravating invasion and tumorigenicity.
    Kim ES, Nam SM, Song HK, Lee S, Kim K, Lim HK, Lee H, Kang KT, Kwon YJ, Chun YJ, Park SY, Jung J, Moon A.

    08/7/2024
    NUCB2 inhibition antagonizes osteosarcoma progression and promotes anti-tumor immunity through inactivating NUCKS1/CXCL8 axis.

    NUCB2 inhibition antagonizes osteosarcoma progression and promotes anti-tumor immunity through inactivating NUCKS1/CXCL8 axis.
    Ji R, Wang Y, Pan D, Han J, Wang Y, Zheng S, Zhao W, Li X, Han C, Zhang L.

    08/6/2024
    Lefty A is involved in sunitinib resistance of renal cell carcinoma cells via regulation of IL-8.

    Lefty A is involved in sunitinib resistance of renal cell carcinoma cells via regulation of IL-8.
    Cui N, Han Q, Cao Q, Wang K, Zhou X, Hou P, Liu C, Chen L, Xu L.

    07/28/2024
    Interleukin-8/CXCR1 Signaling Contributes to the Progression of Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion.

    Interleukin-8/CXCR1 Signaling Contributes to the Progression of Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion.
    Chang YM, Huang WY, Yang SH, Jan CI, Nieh S, Lin YS, Chen SF, Lin YC., Free PMC Article

    07/17/2024
    CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis.

    CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis.
    Vermeersch G, Proost P, Struyf S, Gouwy M, Devos T., Free PMC Article

    07/11/2024
    Enhanced lipid biosynthesis in oral squamous cell carcinoma cancer-associated fibroblasts contributes to tumor progression: Role of IL8/AKT/p-ACLY axis.

    Enhanced lipid biosynthesis in oral squamous cell carcinoma cancer-associated fibroblasts contributes to tumor progression: Role of IL8/AKT/p-ACLY axis.
    Liu P, Wang Y, Li X, Liu Z, Sun Y, Liu H, Shao Z, Jiang E, Zhou X, Shang Z., Free PMC Article

    07/1/2024
    STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1beta-induced IL-8 production.

    STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1β-induced IL-8 production.
    Long J, Zhao W, Xiang Y, Wang Y, Xiang W, Liu X, Jiang M, Song Y, Hu J.

    06/17/2024
    Elevated interleukin-8 expression by skin fibroblasts as a potential contributor to pain in women with Fabry disease.

    Elevated interleukin-8 expression by skin fibroblasts as a potential contributor to pain in women with Fabry disease.
    Hofmann L, Grüner J, Klug K, Breyer M, Klein T, Hochheimer V, Wagenhäuser L, Wischmeyer E, Üçeyler N., Free PMC Article

    04/24/2024
    HIF-1alpha is an important regulator of IL-8 expression in human bone marrow stromal cells under hypoxic microenvironment.

    HIF-1α is an important regulator of IL-8 expression in human bone marrow stromal cells under hypoxic microenvironment.
    Huang Q, You R, Tan M, Cai D, Zou H, Zhang S, Huang H.

    04/22/2024
    Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-kappaB Pathway.

    Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-κB Pathway.
    Lou M, Iwatsuki M, Wu X, Zhang W, Matsumoto C, Baba H.

    04/16/2024
    Interferon-alpha induces differentiation of cancer stem cells and immunosuppression in hepatocellular carcinoma by upregulating CXCL8 secretion.

    Interferon-α induces differentiation of cancer stem cells and immunosuppression in hepatocellular carcinoma by upregulating CXCL8 secretion.
    Ma YT, Zheng L, Zhao CW, Zhang Y, Xu XW, Wang XY, Niu GP, Man ZS, Gu F, Chen YQ.

    03/29/2024
    IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.

    IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.
    Wu J, Zhang Q, Wu J, Yang Z, Liu X, Lou C, Wang X, Peng J, Zhang J, Shang Z, Xiao J, Wang N, Zhang R, Zhou J, Wang Y, Hu Z, Zhang R, Zhang J, Zeng Z., Free PMC Article

    03/8/2024
    Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment.

    Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment.
    Badamasi IM, Muhammad M, Umar AA, Madugu UM, Gadanya MA, Aliyu IA, Kabir IM, Umar IA, Johnson O, Stanslas J., Free PMC Article

    02/20/2024
    Interleukin-8 genetic polymorphism and its relation to Helicobacter pylori infection and Helicobacter pylori-associated gastric diseases.

    Interleukin-8 genetic polymorphism and its relation to Helicobacter pylori infection and Helicobacter pylori-associated gastric diseases.
    Amin IA, Hassan MA, Elgendy SG, Abdelmohsen AS, Ali MY, Abdel-Raady BA.

    02/15/2024
    Reduction of IL-6, IL-8 and beta2-ADRENOCEPTOR mRNA levels in circulating polymorphonuclear leukocytes after adenotonsillectomy in children with Obstructive Sleep Apnea Syndrome.

    Reduction of IL-6, IL-8 and β2-ADRENOCEPTOR mRNA levels in circulating polymorphonuclear leukocytes after adenotonsillectomy in children with Obstructive Sleep Apnea Syndrome.
    Ferrari M, Sica E, De Bernardi F, Luini A, Legnaro M, Nosetti L, Castelnuovo P, Cosentino M, Marino F.

    02/13/2024
    Primary apical periodontitis correlates to elevated levels of interleukin-8 in a Swedish population: A report from the PAROKRANK study.

    Primary apical periodontitis correlates to elevated levels of interleukin-8 in a Swedish population: A report from the PAROKRANK study.
    Sebring D, Kvist T, Lund H, Jonasson P, Lira-Junior R, Norhammar A, Rydén L, Buhlin K, EndoReCo.

    02/8/2024
    Klebsiella pneumoniae outer membrane vesicles induce strong IL-8 expression via NF-kappaB activation in normal pulmonary bronchial cells.

    Klebsiella pneumoniae outer membrane vesicles induce strong IL-8 expression via NF-κB activation in normal pulmonary bronchial cells.
    Li P, Peng T, Xiang T, Luo W, Liao W, Wei DD, Luo S, He Z, Liu P, Zhang W, Liu Y.

    02/7/2024
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