| Mutational Alterations of DNA Methylation-related Genes CTCF, ZFP57, and ATF7IP Genes in Colon Cancers. | Mutational Alterations of DNA Methylation-related Genes CTCF, ZFP57, and ATF7IP Genes in Colon Cancers.
Moon SW, Mo HY, Choi EJ, Yoo NJ, Lee SH., Free PMC Article | 05/7/2022 |
| ZFP57 dictates allelic expression switch of target imprinted genes. | ZFP57 dictates allelic expression switch of target imprinted genes.
Jiang W, Shi J, Zhao J, Wang Q, Cong D, Chen F, Zhang Y, Liu Y, Zhao J, Chen Q, Gu L, Zhou W, Wang C, Fang Z, Geng S, Xie W, Chen LN, Yang Y, Bai Y, Lin H, Li X., Free PMC Article | 06/19/2021 |
| The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances. | The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances.
Monteagudo-Sánchez A, Hernandez Mora JR, Simon C, Burton A, Tenorio J, Lapunzina P, Clark S, Esteller M, Kelsey G, López-Siguero JP, de Nanclares GP, Torres-Padilla ME, Monk D., Free PMC Article | 01/2/2021 |
| ZFP57-MEST and the Wnt/beta-catenin pathway axis are involved in breast tumorigenesis, which may represent a potential diagnostic biomarker, and provide a new insight into a novel therapeutic strategy for breast cancer patients. | ZFP57 suppress proliferation of breast cancer cells through down-regulation of MEST-mediated Wnt/β-catenin signalling pathway.
Chen L, Wu X, Xie H, Yao N, Xia Y, Ma G, Qian M, Ge H, Cui Y, Huang Y, Wang S, Zheng M., Free PMC Article | 04/25/2020 |
| Study demonstrated that ZFP57 plays an important role in the hematogenous metastasis of colorectal cancer, suggesting that it could be used as a novel treatment target. The expression level of ZFP57 was significantly correlated with that of the metastasis-related gene NANOG and ZFP57 overexpression reduced the progression-free survival rate of patients with colorectal cancer. | The Embryonic Stem Cell-Specific Transcription Factor ZFP57 Promotes Liver Metastasis of Colorectal Cancer.
Shoji Y, Takamura H, Ninomiya I, Fushida S, Tada Y, Yokota T, Ohta T, Koide H. | 02/15/2020 |
| Transient neonatal diabetes mellitus in a Turkish patient with three novel homozygous variants in the ZFP57 gene. | Transient neonatal diabetes mellitus in a Turkish patient with three novel homozygous variants in the ZFP57 gene.
Boyraz M, Ulucan K, Taşkın N, Akçay T, Flanagan SE, Mackay DJ., Free PMC Article | 04/22/2019 |
| Data propose that paternal deletions are associated with Silver-Russell syndrome when ZFP57 binding is affected and this happens when one of the three ZFP57 binding regions to H19/IGF2 intergenic differentially methylated region is lost. | Is ZFP57 binding to H19/IGF2:IG-DMR affected in Silver-Russell syndrome?
Sparago A, Cerrato F, Riccio A., Free PMC Article | 03/2/2019 |
| transient neonatal diabetes type 1 is associated with ZFP57 mutations | Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57.
Bak M, Boonen SE, Dahl C, Hahnemann JM, Mackay DJ, Tümer Z, Grønskov K, Temple IK, Guldberg P, Tommerup N., Free PMC Article | 05/14/2016 |
| ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth | The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells.
Tada Y, Yamaguchi Y, Kinjo T, Song X, Akagi T, Takamura H, Ohta T, Yokota T, Koide H. | 04/11/2015 |
| High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C. | High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism.
Cirillo A, Di Salle A, Petillo O, Melone MA, Grimaldi G, Bellotti A, Torelli G, De' Santi MS, Cantatore G, Marinelli A, Galderisi U, Peluso G., Free PMC Article | 01/24/2015 |
| These data identify ZFP57 as a candidate gene underlying reported MHC disease associations, notably for putative regulatory variants associated with cancer and HIV-1. | Fine mapping genetic determinants of the highly variably expressed MHC gene ZFP57.
Plant K, Fairfax BP, Makino S, Vandiedonck C, Radhakrishnan J, Knight JC., Free PMC Article | 11/22/2014 |
| Mouse and human ZFP57 are orthologs despite relatively low sequence identity. | Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cells.
Takikawa S, Wang X, Ray C, Vakulenko M, Bell FT, Li X., Free PMC Article | 05/24/2014 |
| hZFP57 mutations and hypomethylation of the TNDM1 imprinted control region both associated with Transient Neonatal Diabetes Mellitus type 1 result in loss of hZFP57 binding to the TNDM1 locus. | Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1.
Baglivo I, Esposito S, De Cesare L, Sparago A, Anvar Z, Riso V, Cammisa M, Fattorusso R, Grimaldi G, Riccio A, Pedone PV., Free PMC Article | 07/27/2013 |
| no evidence for ZFP57 alterations as a major cause in sporadic Beckwith-Wiedemann Syndrome cases | No evidence for pathogenic variants or maternal effect of ZFP57 as the cause of Beckwith-Wiedemann Syndrome.
Boonen SE, Hahnemann JM, Mackay D, Tommerup N, Brøndum-Nielsen K, Tümer Z, Grønskov K., Free PMC Article | 04/7/2012 |
| this study does not provide evidence that ZFP57 mutations are the cause of 11p15-hypomethylation in Silver-Russell syndrome (SRS) patients and contribute to the aetiology of SRS | Screening for genomic variants in ZFP57 in Silver-Russell syndrome patients with 11p15 epimutations.
Spengler S, Gogiel M, Schönherr N, Binder G, Eggermann T. | 02/8/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA., Free PMC Article | 01/20/2010 |
| Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features. | Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57.
Mackay DJ, Callaway JL, Marks SM, White HE, Acerini CL, Boonen SE, Dayanikli P, Firth HV, Goodship JA, Haemers AP, Hahnemann JM, Kordonouri O, Masoud AF, Oestergaard E, Storr J, Ellard S, Hattersley AT, Robinson DO, Temple IK. | 01/21/2010 |