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    APC APC regulator of WNT signaling pathway [ Homo sapiens (human) ]

    Gene ID: 324, updated on 18-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    APC and ZBTB2 May Mediate M2 Macrophage Infiltration to Promote the Development of Renal Fibrosis: A Bioinformatics Analysis.

    APC and ZBTB2 May Mediate M2 Macrophage Infiltration to Promote the Development of Renal Fibrosis: A Bioinformatics Analysis.
    Song J, Ke B, Fang X., Free PMC Article

    10/7/2024
    Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APC[Min/+] Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-kappaB Signaling Pathway.

    Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APC(Min/+) Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-κB Signaling Pathway.
    Arteaga-Blanco LA, Evans AE, Dixon DA., Free PMC Article

    08/1/2024
    Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.

    Bcl-2 Up-Regulation Mediates Taxane Resistance Downstream of APC Loss.
    Wise AR, Maloney S, Hering A, Zabala S, Richmond GE, VanKlompenberg MK, Nair MT, Prosperi JR., Free PMC Article

    07/5/2024
    Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor.

    Mutational analysis of pulmonary large cell neuroendocrine carcinoma: APC gene mutations identify a good prognostic factor.
    Li M, Zhang Y, Zhou P, Miao Y, Li S, Jiang L.

    06/13/2024
    BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.

    BET protein-dependent E2F pathway activity confers bell-shaped type resistance to tankyrase inhibitors in APC-mutated colorectal cancer.
    Morino S, Mashima T, Shirai F, Nagayama S, Katayama R, Seimiya H.

    02/28/2024
    beta-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.

    β-catenin mediates growth defects induced by centrosome loss in a subset of APC mutant colorectal cancer independently of p53.
    Bourmoum M, Radulovich N, Sharma A, Tkach JM, Tsao MS, Pelletier L., Free PMC Article

    02/20/2024
    Case Series of Men with the Germline APC I1307K variant and Treatment-Emergent Neuroendocrine Prostate Cancer.

    Case Series of Men with the Germline APC I1307K variant and Treatment-Emergent Neuroendocrine Prostate Cancer.
    Economides MP, Nakazawa M, Lee JW, Li X, Hollifield L, Chambers R, Sarfaty M, Goldberg JD, Antonarakis ES, Wise DR.

    02/16/2024
    Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan.

    Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan.
    Miyakura Y, Yamaguchi T, Lefor AK, Tamaki S, Takao A, Takao M, Mori Y, Chikatani K, Ishida H, Kono M, Takeuchi Y, Ishikawa H, Nagasaki T, Sasaki K, Matsubara T, Hirata K, Taniguchi F, Tanakaya K, Tomita N, Ajioka Y.

    02/5/2024
    A novel APC mutation associated with Gardner syndrome in a Chinese family.

    A novel APC mutation associated with Gardner syndrome in a Chinese family.
    Zeng M, Yao X, Pan Y, Gu H, Xiong F, Yin X, Wu B, Chen T.

    02/1/2024
    APC mutations disrupt beta-catenin destruction complex condensates organized by Axin phase separation.

    APC mutations disrupt β-catenin destruction complex condensates organized by Axin phase separation.
    Zhang D, Ni QQ, Wang SY, He WF, Hong ZX, Liu HY, Chen XH, Chen LJ, Han FY, Zhang LJ, Li XM, Ding YQ, Jiao HL, Ye YP., Free PMC Article

    01/30/2024
    APC/PIK3CA mutations and beta-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells.

    APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells.
    Chen M, Mashima T, Oishi T, Muramatsu Y, Seto Y, Takamatsu M, Kawata N, Morino S, Nakamura A, Inaba S, Yuan X, Maruyama K, Suzuki M, Sato A, Yoshida H, Jang MK, Mizutani A, Takeuchi K, Yamaguchi K, Shirai F, Nagayama S, Katayama R, Seimiya H., Free PMC Article

    01/12/2024
    A one-stop approach to diagnosing hereditary colorectal cancer in the Chinese population.

    A one-stop approach to diagnosing hereditary colorectal cancer in the Chinese population.
    Li C, Song W, Xu Y, Guo T, Zhou X, Liu F, Xu Y.

    01/4/2024
    Low adenoma burden in unselected patients with a pathogenic APC variant.

    Low adenoma burden in unselected patients with a pathogenic APC variant.
    Schwiter R, Rocha H, Johns A, Savatt JM, Diehl DL, Kelly MA, Williams MS, Buchanan AH.

    12/20/2023
    An update of the variant spectrum of the APC gene in Iranian familial adenomatous polyposis patients.

    An update of the variant spectrum of the APC gene in Iranian familial adenomatous polyposis patients.
    Mirabdolhosseini SM, Rejali L, Yaghoob Taleghani M, Sadeghi H, Kashfi SMH, Behboudi Farahbakhsh F, Golmohammadi M, Larki P, Fatemi N, Ketabi Moghadam P, Nazemalhosseini Mojarad E, Sadeghi A, Asadzadeh Aghdaie H, Zali MR.

    12/15/2023
    Usefulness of genotyping APC gene for individualizing management of patients with familial adenomatous polyposis.

    Usefulness of genotyping APC gene for individualizing management of patients with familial adenomatous polyposis.
    Mori Y, Ishida H, Chika N, Ito T, Amano K, Chikatani K, Takeuchi Y, Kono M, Shichijo S, Chino A, Nagasaki T, Takao A, Takao M, Nakamori S, Sasaki K, Akagi K, Yamaguchi T, Tanakaya K, Naohiro T, Ajioka Y.

    12/4/2023
    Germline APC Alterations May Predispose to Testicular Sex Cord-Stromal Tumors.

    Germline APC Alterations May Predispose to Testicular Sex Cord-Stromal Tumors.
    Siegmund S, Ricci C, Kao CS, Sangoi AR, Mohanty S, Fletcher CDM, Colecchia M, Acosta AM.

    11/18/2023
    CTNNB1 and APC Mutations in Sinonasal Myxoma : Expanding the Spectrum of Tumors Driven By WNT/beta-catenin Pathway.

    CTNNB1 and APC Mutations in Sinonasal Myxoma : Expanding the Spectrum of Tumors Driven By WNT/β-catenin Pathway.
    Chen S, Gallant S, Cunningham MJ, Robson CD, Church AJ, Perez-Atayde AR, Al-Ibraheemi A.

    10/30/2023
    Clinical significance of SPOP and APC gene alterations in colorectal cancer in Indian population.

    Clinical significance of SPOP and APC gene alterations in colorectal cancer in Indian population.
    Ali A, Nimisha, Sharma AK, Mishra PK, Saluja SS.

    07/25/2023
    Long noncoding RNA UFC1 acts as an oncogene via stimulating EZH2-induced inhibition of APC expression in renal cell carcinoma.

    Long noncoding RNA UFC1 acts as an oncogene via stimulating EZH2-induced inhibition of APC expression in renal cell carcinoma.
    Wang J, Liu G.

    06/28/2023
    The adenomatous polyposis coli protein 30 years on.

    The adenomatous polyposis coli protein 30 years on.
    Abbott J, Näthke IS.

    06/5/2023
    Let-7b-5p inhibits colon cancer progression by prohibiting APC ubiquitination degradation and the Wnt pathway by targeting NKD1.

    Let-7b-5p inhibits colon cancer progression by prohibiting APC ubiquitination degradation and the Wnt pathway by targeting NKD1.
    Dai Y, Liu J, Li X, Deng J, Zeng C, Lu W, Hou Y, Sheng Y, Wu H, Liu Q., Free PMC Article

    05/7/2023
    APC germline pathogenic variants and epithelial ovarian cancer: causal or coincidental findings?

    APC germline pathogenic variants and epithelial ovarian cancer: causal or coincidental findings?
    Vibert R, Le Gall J, Buecher B, Mouret-Fourme E, Bataillon G, Becette V, Trabelsi-Grati O, Moncoutier V, Dehainault C, Carriere J, Schwartz M, Suybeng V, Bieche I, Colas C, Vincent-Salomon A, Stoppa-Lyonnet D, Golmard L.

    04/26/2023
    Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.

    Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.
    Panyarat C, Nakornchai S, Chintakanon K, Leelaadisorn N, Intachai W, Olsen B, Tongsima S, Adisornkanj P, Ngamphiw C, Cox TC, Kantaputra P., Free PMC Article

    03/15/2023
    Impact of a haplotype (composed of the APC, KRAS, and TP53 genes) on colorectal adenocarcinoma differentiation and patient prognosis.

    Impact of a haplotype (composed of the APC, KRAS, and TP53 genes) on colorectal adenocarcinoma differentiation and patient prognosis.
    Peng X, Zhang T, Jia X, Wang T, Lin H, Li G, Li R, Zhang A.

    12/3/2022
    Constitutional chromothripsis of the APC locus as a cause of genetic predisposition to colon cancer.

    Constitutional chromothripsis of the APC locus as a cause of genetic predisposition to colon cancer.
    Scharf F, Leal Silva RM, Morak M, Hastie A, Pickl JMA, Sendelbach K, Gebhard C, Locher M, Laner A, Steinke-Lange V, Koehler U, Holinski-Feder E, Wolf DA., Free PMC Article

    10/29/2022
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