| Delayed notochordal cell disappearance through integrin alpha5beta1 mechanotransduction during ex-vivo dynamic loading-induced intervertebral disc degeneration. | Delayed notochordal cell disappearance through integrin α5β1 mechanotransduction during ex-vivo dynamic loading-induced intervertebral disc degeneration.
Kanda Y, Yurube T, Morita Y, Takeoka Y, Kurakawa T, Tsujimoto R, Miyazaki K, Kakiuchi Y, Miyazaki S, Zhang Z, Takada T, Hoshino Y, Masuda K, Kuroda R, Kakutani K. | 04/23/2022 |
| Integrin alphanubeta3 modulates lipopolysaccharide-induced hyperpermeability in cardiac microvascular endothelial cells. | Integrin ανβ3 modulates lipopolysaccharide-induced hyperpermeability in cardiac microvascular endothelial cells.
Li L, Rongfang Z, Junhai Z, Changqin C, Jing Y. | 02/13/2021 |
| Titanium with nanotopography induces osteoblast differentiation through regulation of integrin alphaV. | Titanium with nanotopography induces osteoblast differentiation through regulation of integrin αV.
Lopes HB, Freitas GP, Fantacini DMC, Picanço-Castro V, Covas DT, Rosa AL, Beloti MM. | 09/5/2020 |
| These results indicate that integrin alpha5beta1 expression on dopaminergic neurons plays an important role in the dopaminergic neurite outgrowth on striatal neurons. | Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons.
Izumi Y, Wakita S, Kanbara C, Nakai T, Akaike A, Kume T., Free PMC Article | 11/3/2018 |
| Transduction of rat bone marrow mesenchymal stem cells with ITGA5B1 lentivirus could prevent cell anoikis and increase nitric oxide production. | Integrin alpha5beta1 suppresses rBMSCs anoikis and promotes nitric oxide production.
Chen HY, Pan L, Yang HL, Xia P, Yu WC, Tang WQ, Zhang YX, Chen SF, Xue YZ, Wang LX. | 08/25/2018 |
| alpha 5 integrin promotes brain metastases in cancer cells and may mediate early steps in the metastatic cascade, such as adhesion to brain vasculature. Targeting alphav integrin with intetumumab could provide clinical benefit in treating cancer patients who develop metastases. | High αv Integrin Level of Cancer Cells Is Associated with Development of Brain Metastasis in Athymic Rats.
Wu YJ, Pagel MA, Muldoon LL, Fu R, Neuwelt EA., Free PMC Article | 08/12/2017 |
| This is the first study to detail the signaling pathway triggered by alphavbeta3, the endogenous Thy-1 ligand, highlighting the role of membrane-bound integrins as trans acting ligands in astrocyte-neuron communication | Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.
Maldonado H, Calderon C, Burgos-Bravo F, Kobler O, Zuschratter W, Ramirez O, Härtel S, Schneider P, Quest AF, Herrera-Molina R, Leyton L. | 06/24/2017 |
| The membrane fraction of diabetic-derived fibroblasts showed a decrease of integrin subunits alpha5 and alphav, which was confirmed by immunocytochemistry assays. | Hyperglycemia reduces integrin subunits alpha v and alpha 5 on the surface of dermal fibroblasts contributing to deficient migration.
Almeida ME, Monteiro KS, Kato EE, Sampaio SC, Braga TT, Câmara NO, Lamers ML, Santos MF. | 02/18/2017 |
| this study shows that experimental iabetes interferes with the osseointegration of implants by deferring expression of fibronectin and integrin alpha5beta1 | Potential mechanism for osseointegration of dental implants in Zucker diabetic fatty rats.
Liu Z, Zhou W, Tangl S, Liu S, Xu X, Rausch-Fan X. | 02/4/2017 |
| Data indicate that estradiol-induced activation of integrin alpha5beta1 accelerates behavioral recovery of 6-OHDA-esioned hemi-Parkinsonian model. | Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1.
Nishimura K, Doi D, Samata B, Murayama S, Tahara T, Onoe H, Takahashi J., Free PMC Article | 01/14/2017 |
| Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit. | Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis.
Garciadiego-Cázares D, Aguirre-Sánchez HI, Abarca-Buis RF, Kouri JB, Velasquillo C, Ibarra C., Free PMC Article | 04/23/2016 |
| Integrin alphaVbeta3 facilitates Ca(2+) wave generation through a signaling cascade, involving phospholipase Cgamma1, inositol 1,3,4 triphosphate production, and inositol 1, 4, 5-triphosphate receptor activation. | Implications of αvβ3 Integrin Signaling in the Regulation of Ca2+ Waves and Myogenic Tone in Cerebral Arteries.
Mufti RE, Zechariah A, Sancho M, Mazumdar N, Brett SE, Welsh DG. | 03/19/2016 |
| The number of integrin alpha5- and alphav-positive cells markedly increased at day 3 and then gradually decreased, but was still elevated on day 14 after laser-induced choroidal neovascularization . | Mechanism for laser-induced neovascularization in rat choroid: accumulation of integrin α chain-positive cells and their ligands.
Nakajima T, Hirata M, Shearer TR, Azuma M., Free PMC Article | 10/4/2014 |
| Tauroursodeoxycholic acid induces in perfused rat liver and human HepG2 cells the rapid appearance of the active conformation of the beta subunit of alpha5beta1 integrins, followed by an activating phosphorylation of extracellular signal-regulated kinases. | α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes.
Gohlke H, Schmitz B, Sommerfeld A, Reinehr R, Häussinger D. | 04/27/2013 |
| Mechanical force transduced by alpha(5)beta(1)-integrins triggered a myogenic response-like behavior in isolated renal vascular smooth muscle cells. | Remanent cell traction force in renal vascular smooth muscle cells induced by integrin-mediated mechanotransduction.
Balasubramanian L, Lo CM, Sham JS, Yip KP., Free PMC Article | 04/13/2013 |
| v beta 3 has a role in choroidal neovascularization in a rat model | Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization.
Salehi-Had H, Roh MI, Giani A, Hisatomi T, Nakao S, Kim IK, Gragoudas ES, Vavvas D, Guccione S, Miller JW., Free PMC Article | 12/3/2011 |
| elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin | Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents.
Lee B, Clarke D, Al Ahmad A, Kahle M, Parham C, Auckland L, Shaw C, Fidanboylu M, Orr AW, Ogunshola O, Fertala A, Thomas SA, Bix GJ., Free PMC Article | 10/8/2011 |
| Data show that EGFR, via interaction with FcvarepsilonRI and integrin alpha(5), is necessary for allergic inflammation associated with cellular interaction. | Integrin α(5) interacts with EGFR, is necessary for FcɛRI signaling and is necessary for allergic inflammation in relation with angiogenesis.
Kim Y, Kim K, Park D, Eom S, Park H, Lee H, Lee YS, Choe J, Hahn JH, Kim YM, Ro JY, Jeoung D. | 06/18/2011 |
| Engagement of alpha5beta1-integrin by fibronectin acutely enhances Cav1.2 calcium channel current in rat arteriolar smooth muscle cells expressing Cav1.2. | Spatial association of the Cav1.2 calcium channel with α5β1-integrin.
Chao JT, Gui P, Zamponi GW, Davis GE, Davis MJ., Free PMC Article | 04/23/2011 |
| Data suggest that in a dynamic mechanical environment such as the vascular wall, thermodynamic binding properties between fibronectin and alpha5beta1 integrin vary in relation to locally applied loads and divalent cations concentrations. | Mg2+ modulates integrin-extracellular matrix interaction in vascular smooth muscle cells studied by atomic force microscopy.
Trache A, Trzeciakowski JP, Meininger GA. | 07/5/2010 |
| study has successfully demonstrated the expression of alpha(V)beta(3) in rat endometrial epithelial cells as a marker of endometrial receptivity and showed that this molecule is indispensable for the process of implantation in this species | Expression of alphaVbeta3 integrin in rat endometrial epithelial cells and its functional role during implantation.
Srinivasan KR, Blesson CS, Fatima I, Kitchlu S, Jain SK, Mehrotra PK, Dwivedi A. | 01/21/2010 |
| Data show that the long-lasting induction of integrin alpha 5 subunits occurrs in reactive astrocytes following transient forebrain ischemia. | Differential regulation of osteopontin receptors, CD44 and the alpha(v) and beta(3) integrin subunits, in the rat hippocampus following transient forebrain ischemia.
Kang WS, Choi JS, Shin YJ, Kim HY, Cha JH, Lee JY, Chun MH, Lee MY. | 01/21/2010 |
| Data suggest that integrin alpha5-related EGF receptor activation by prothrombin can induce cell growth inhibition and apoptosis via an EGFR-JNK signaling pathway. | Integrin alpha5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway.
Wang Z, Wang M, Carr BI. | 01/21/2010 |
| The objective of the present study was to examine the role of uterine mechanical stretching in the regulation of FN and ITGA5 expression at late gestation and during labor. | Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats.
Shynlova O, Williams SJ, Draper H, White BG, MacPhee DJ, Lye SJ. | 01/21/2010 |
| Endothelial cell integrin alphaV beta3 is involved in sickle cell red blood cell adhesion. | Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion.
Finnegan EM, Barabino GA, Liu XD, Chang HY, Jonczyk A, Kaul DK. | 01/21/2010 |