| CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA. | CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA.
Zhang Y, Chen XN, Zhang H, Wen JK, Gao HT, Shi B, Wang DD, Han ZW, Gu JF, Zhao CM, Xue WY, Zhang YP, Qu CB, Yang Z., Free PMC Article | 01/6/2024 |
| Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD. | Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD.
Cao H, Cai Q, Guo W, Su Q, Qin H, Wang T, Xian Y, Zeng L, Cai M, Guan H, Chen S, Liang H, Xu F. | 10/6/2023 |
| Involvement of ACACA (acetyl-CoA carboxylase alpha) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts. | Involvement of ACACA (acetyl-CoA carboxylase α) in the lung pre-metastatic niche formation in breast cancer by senescence phenotypic conversion in fibroblasts.
Huang YC, Hou MF, Tsai YM, Pan YC, Tsai PH, Lin YS, Chang CY, Tsai EM, Hsu YL., Free PMC Article | 08/25/2023 |
| Identification of acetyl-CoA carboxylase alpha as a prognostic and targeted candidate for hepatocellular carcinoma. | Identification of acetyl-CoA carboxylase alpha as a prognostic and targeted candidate for hepatocellular carcinoma.
Shen Y, Wang X, Ni Z, Xu S, Qiu S, Zheng W, Zhang J. | 06/29/2023 |
| Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-kappaB-snail axis. | Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis.
Saisomboon S, Kariya R, Boonnate P, Sawanyawisuth K, Cha'on U, Luvira V, Chamgramol Y, Pairojkul C, Seubwai W, Silsirivanit A, Wongkham S, Okada S, Jitrapakdee S, Vaeteewoottacharn K. | 05/12/2023 |
| Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial beta-oxidation in castration-resistant prostate cancer cells. | Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells.
Liu S, Lai J, Feng Y, Zhuo Y, Zhang H, Chen Y, Li J, Mei X, Zeng Y, Su J, Deng Y, Jiang F, Yang S, Tan H, Hon CT, Wei S, Han Z, Wang F, Zhong W., Free PMC Article | 02/4/2023 |
| circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer. | circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
Yang Y, Luo D, Shao Y, Shan Z, Liu Q, Weng J, He W, Zhang R, Li Q, Wang Z, Li X., Free PMC Article | 01/28/2023 |
| [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells]. | [Research on the mechanism of hypoxia promoting the migration of lung adenocarcinoma A549 cells].
Jin JH, Zhao BS, Liu YZ. | 06/11/2022 |
| MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase. | MIG12 is involved in the LXR activation-mediated induction of the polymerization of mammalian acetyl-CoA carboxylase.
Izumi A, Hiraguchi H, Kodaka M, Ikeuchi E, Narita J, Kobayashi R, Matsumoto Y, Suzuki T, Yamamoto Y, Sato R, Inoue J. | 11/22/2021 |
| ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials. | ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Calle RA, Amin NB, Carvajal-Gonzalez S, Ross TT, Bergman A, Aggarwal S, Crowley C, Rinaldi A, Mancuso J, Aggarwal N, Somayaji V, Inglot M, Tuthill TA, Kou K, Boucher M, Tesz G, Dullea R, Bence KK, Kim AM, Pfefferkorn JA, Esler WP. | 11/13/2021 |
| SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells. | SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells.
Jhu JW, Yan JB, Lin ZH, Lin SC, Peng IC., Free PMC Article | 10/23/2021 |
| Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development. | Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.
Ito H, Nakamae I, Kato JY, Yoneda-Kato N., Free PMC Article | 10/9/2021 |
| A novel gravity-induced blood flow restriction model augments ACC phosphorylation and PGC-1alpha mRNA in human skeletal muscle following aerobic exercise: a randomized crossover study. | A novel gravity-induced blood flow restriction model augments ACC phosphorylation and PGC-1α mRNA in human skeletal muscle following aerobic exercise: a randomized crossover study.
Preobrazenski N, Islam H, Drouin PJ, Bonafiglia JT, Tschakovsky ME, Gurd BJ. | 10/2/2021 |
| UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes. | UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes.
Tian YD, Chung MH, Quan QL, Lee DH, Kim EJ, Chung JH., Free PMC Article | 05/29/2021 |
| Circular RNA circACACA regulates proliferation, migration and glycolysis in nonsmallcell lung carcinoma via miR1183 and PI3K/PKB pathway. | Circular RNA circ‑ACACA regulates proliferation, migration and glycolysis in non‑small‑cell lung carcinoma via miR‑1183 and PI3K/PKB pathway.
Wu W, Xi W, Li H, Yang M, Yao X., Free PMC Article | 01/23/2021 |
| Human Acetyl-CoA Carboxylase 1 Is an Isomerase: Carboxyl Transfer Is Activated by Catalytic Effect of Isomerization. | Human Acetyl-CoA Carboxylase 1 Is an Isomerase: Carboxyl Transfer Is Activated by Catalytic Effect of Isomerization.
Wang X, Li Y, Chen X, Zhou Z, Yao J. | 09/5/2020 |
| High ACC expression is associated with metabolic syndrome. | Sex Hormone-Binding Globulin Expression Correlates With Acetyl-Coenzyme A Carboxylase and Triglyceride Content in Human Liver.
Sáez-López C, Salcedo-Allende MT, Hernandez C, Simó-Servat O, Simó R, Selva DM. | 02/29/2020 |
| We for the first time verified that ACC1 mRNA was upregulated in non-small-cell lung cancer (NSCLC), and higher ACC1 level was correlated with poor outcome in lung cancer patients, indicating ACC1 might be as a prognostic index for NSCLC patients. | Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors.
Li EQ, Zhao W, Zhang C, Qin LZ, Liu SJ, Feng ZQ, Wen X, Chen CP. | 01/18/2020 |
| These results support the idea that C-rich sequences within the promoters (PI and PII) of ACC1 can form intramolecular i-motif structures, cause suppression of transcription, and thus reveal the functional significance of C-rich sequences in the regulation of ACC1 gene expression. | Structural Characterization of i-Motif Structure in the Human Acetyl-CoA Carboxylase 1 Gene Promoters and Their Role in the Regulation of Gene Expression.
Kaulage MH, Bhattacharya S, Muniyappa K. | 07/20/2019 |
| Among the proteins differentially expressed after treatment with exosome-like nanoparticles from Citrus-limon juice, we found a significant downregulation of the Acetyl-CoA Carboxylase 1 (ACACA) and we demonstrated that silencing ACACA in cancer cells leads to a reduction of cell growth. | Label-free quantitative proteomic profiling of colon cancer cells identifies acetyl-CoA carboxylase alpha as antitumor target of Citrus limon-derived nanovesicles.
Raimondo S, Saieva L, Cristaldi M, Monteleone F, Fontana S, Alessandro R. | 07/13/2019 |
| Results show that the phosphorylation of the N-terminal regulatory domain decreases ACC1 activity, while phosphorylation in its central domain has no effect. Inhibition of the activity by phosphorylation is significantly more profound at citrate concentrations below 2 mm. Furthermore, deletion of the N-terminal domain facilitates structural changes induced by citrate, including conversion of ACC dimers to linear polymers. | Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.
Jang S, Gornicki P, Marjanovic J, Bass E, P Iurcotta T, Rodriguez P, Austin J 2nd, Haselkorn R. | 05/11/2019 |
| cryo-electron microscopy structures of an ACC1 activated filament that is allosterically induced by citrate (ACC-citrate), and an inactivated filament form that results from binding of the BRCT domains of the breast cancer type 1 susceptibility protein (BRCA1) | Structural basis for regulation of human acetyl-CoA carboxylase.
Hunkeler M, Hagmann A, Stuttfeld E, Chami M, Guri Y, Stahlberg H, Maier T. | 12/22/2018 |
| These data showed that ACC1 gene (ACACA) expression was twofold greater in HCC compared to non-cancerous liver. | Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
Nelson ME, Lahiri S, Chow JD, Byrne FL, Hargett SR, Breen DS, Olzomer EM, Wu LE, Cooney GJ, Turner N, James DE, Slack-Davis JK, Lackner C, Caldwell SH, Hoehn KL., Free PMC Article | 11/17/2018 |
| the present studies report for the first time a role of ACC1 in suppressing breast cancer migration and invasion by an fatty acid synthesis-independent, but acetyl-CoA-dependent, impact on the epithelial-mesenchymal transition programs in breast tumor cells and its subsequent importance for tumor invasion and recurrence. | Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.
Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, Christian S, Hess-Stumpp H, Augustin HG, Müller-Decker K, Nawroth PP, Herzig S, Berriel Diaz M. | 07/21/2018 |
| the presence of an internal ribosome entry site in the ACC1 5' UTR allows ACC1 mRNA translation in conditions that are inhibitory to cap-dependent translation. | Translational control of human acetyl-CoA carboxylase 1 mRNA is mediated by an internal ribosome entry site in response to ER stress, serum deprivation or hypoxia mimetic CoCl(2).
Damiano F, Testini M, Tocci R, Gnoni GV, Siculella L. | 06/2/2018 |