| HCK Promotes High-Grade Serous Ovarian Cancer Tumorigenesis through CD44 and NOTCH3 Signaling. | HCK Promotes High-Grade Serous Ovarian Cancer Tumorigenesis through CD44 and NOTCH3 Signaling.
Khella CA, Franciosa L, Rodirguez-Rodriguez L, Rajkarnikar R, Mythreye K, Gatza ML. | 10/23/2023 |
| A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas. | A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas.
Munshi M, Liu X, Kofides A, Tsakmaklis N, Guerrera ML, Hunter ZR, Palomba ML, Argyropoulos KV, Patterson CJ, Canning AG, Meid K, Gustine J, Branagan AR, Flynn CA, Sarosiek S, Castillo JJ, Wang J, Buhrlage SJ, Gray NS, Munshi NC, Anderson KC, Treon SP, Yang G., Free PMC Article | 06/18/2022 |
| Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK. | Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK.
Dhami K, Chakraborty A, Gururaja TL, Cheung LW, Sun C, DeAnda F, Huang X. | 06/11/2022 |
| HCK is a Potential Prognostic Biomarker that Correlates with Immune Cell Infiltration in Acute Myeloid Leukemia. | HCK is a Potential Prognostic Biomarker that Correlates with Immune Cell Infiltration in Acute Myeloid Leukemia.
Cheng F, Li Q, Wang J, Wang L, Li W, Zeng F., Free PMC Article | 04/2/2022 |
| miR-181b and miR-204 suppress the VSMC proliferation and migration by downregulation of HCK. | miR-181b and miR-204 suppress the VSMC proliferation and migration by downregulation of HCK.
Ghasempour G, Mahabadi VP, Shabani M, Mohammadi A, Zamani-Garmsiri F, Amirfarhangi A, Karimi M, Najafi M. | 01/8/2022 |
| HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML. | HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML.
Li Z, Wang F, Tian X, Long J, Ling B, Zhang W, Xu J, Liang A., Free PMC Article | 12/11/2021 |
| Nucleotide binding domain and leucine-rich repeat pyrin domain-containing protein 12: characterization of its binding to hematopoietic cell kinase. | Nucleotide binding domain and leucine-rich repeat pyrin domain-containing protein 12: characterization of its binding to hematopoietic cell kinase.
Zhang Y, Okamoto CT., Free PMC Article | 08/28/2021 |
| HCK can serve as novel prognostic biomarker and therapeutic target for Breast Cancer patients. | HCK can serve as novel prognostic biomarker and therapeutic target for Breast Cancer patients.
Zhu X, Zhang Y, Bai Y, Gu X, Chen G, Sun L, Wang Y, Qiao X, Ma Q, Zhu T, Bu J, Xue J, Liu C., Free PMC Article | 08/7/2021 |
| Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative. | Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative.
Chakraborty MP, Bhattacharyya S, Roy S, Bhattacharya I, Das R, Mukherjee A., Free PMC Article | 07/17/2021 |
| Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma. | Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma.
Lantermans HC, Minderman M, Kuil A, Kersten MJ, Pals ST, Spaargaren M., Free PMC Article | 03/27/2021 |
| HCK promotes glioblastoma progression by TGFbeta signaling. | HCK promotes glioblastoma progression by TGFβ signaling.
Wang Z, Ying C, Zhang A, Xu H, Jiang Y, Lou M., Free PMC Article | 03/27/2021 |
| Membrane Anchoring of Hck Kinase via the Intrinsically Disordered SH4-U and Length Scale Associated with Subcellular Localization. | Membrane Anchoring of Hck Kinase via the Intrinsically Disordered SH4-U and Length Scale Associated with Subcellular Localization.
Pond MP, Eells R, Treece BW, Heinrich F, Lösche M, Roux B., Free PMC Article | 10/31/2020 |
| These studies show that Hck and Fgr expression influences inhibitor sensitivity and the pathway to acquired resistance in Flt3-ITD+ AML. | Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance.
Patel RK, Weir MC, Shen K, Snyder D, Cooper VS, Smithgall TE., Free PMC Article | 03/28/2020 |
| These results suggest that the estrogen-autophagy-STAT3-HCK axis participates in the differentiation of PTGS2(high) IFNG(low) PRF1(low) GZMB(low) FCGR3(-) NK cells in ectopic lesion microenvironment. | Suppression of autophagy and HCK signaling promotes PTGS2(high) FCGR3(-) NK cell differentiation triggered by ectopic endometrial stromal cells.
Mei J, Zhou WJ, Zhu XY, Lu H, Wu K, Yang HL, Fu Q, Wei CY, Chang KK, Jin LP, Wang J, Wang YM, Li DJ, Li MQ., Free PMC Article | 10/12/2019 |
| HIV infection induced Hck activation.Myeloid cells require Hck for ADAM17 activation and secretion | HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles.
Lee JH, Ostalecki C, Zhao Z, Kesti T, Bruns H, Simon B, Harrer T, Saksela K, Baur AS., Free PMC Article | 11/10/2018 |
| Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck-dependent activation of PKCdelta, which stimulates PKCgamma, resulting in translocation of phosphorylated p47(phox). | LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils.
Kelher MR, McLaughlin NJ, Banerjee A, Elzi DJ, Gamboni F, Khan SY, Meng X, Mitra S, Silliman CC., Free PMC Article | 09/2/2017 |
| HCK represents a novel target for therapeutic development in MYD88-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88. | HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib.
Yang G, Buhrlage SJ, Tan L, Liu X, Chen J, Xu L, Tsakmaklis N, Chen JG, Patterson CJ, Brown JR, Castillo JJ, Zhang W, Zhang X, Liu S, Cohen P, Hunter ZR, Gray N, Treon SP. | 08/5/2017 |
| High HCK levels correlate with reduced survival of colorectal cancer patients and is associated with activated macrophages gene signature. | Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression.
Poh AR, Love CG, Masson F, Preaudet A, Tsui C, Whitehead L, Monard S, Khakham Y, Burstroem L, Lessene G, Sieber O, Lowell C, Putoczki TL, O'Donoghue RJJ, Ernst M., Free PMC Article | 06/24/2017 |
| three-dimensional (3D) QSAR pharmacophore models were generated for Hck based on experimentally known inhibitors. A best pharmacophore model, Hypo1, was developed with high correlation coefficient (0.975), Low RMS deviation (0.60) and large cost difference (49.31), containing three ring aromatic and one hydrophobic aliphatic feature | Novel virtual lead identification in the discovery of hematopoietic cell kinase (HCK) inhibitors: application of 3D QSAR and molecular dynamics simulation.
Bavi R, Kumar R, Rampogu S, Kim Y, Kwon YJ, Park SJ, Lee KW. | 06/10/2017 |
| we provide evidence for involvement of HCK and FGR in FCRL4-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 molecule. | Involvement of the HCK and FGR src-family kinases in FCRL4-mediated immune regulation.
Liu Y, Bezverbnaya K, Zhao T, Parsons MJ, Shi M, Treanor B, Ehrhardt GR., Free PMC Article | 08/22/2015 |
| Interaction with the Src homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment. | Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.
Alvarado JJ, Tarafdar S, Yeh JI, Smithgall TE., Free PMC Article | 02/7/2015 |
| Interaction between Nef and Hck is important for Nef-dependent modulation of viral infectivity. | HIV-1 infection of T cells and macrophages are differentially modulated by virion-associated Hck: a Nef-dependent phenomenon.
Cornall A, Mak J, Greenway A, Tachedjian G., Free PMC Article | 03/8/2014 |
| Data indicate that combined treatment using SFK (LYN, HCK, or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 activity and enhancing targeting of acute myeloid leukemia (AML) stem cells. | The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.
Dos Santos C, McDonald T, Ho YW, Liu H, Lin A, Forman SJ, Kuo YH, Bhatia R., Free PMC Article | 11/16/2013 |
| The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model. | The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model.
Asai T, Morrison SL., Free PMC Article | 06/8/2013 |
| This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase. | Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix).
Shi X, Betzi S, Lugari A, Opi S, Restouin A, Parrot I, Martinez J, Zimmermann P, Lecine P, Huang M, Arold ST, Collette Y, Morelli X., Free PMC Article | 09/29/2012 |