| NPC1L1 rs217434 A > G as a Novel Single Nucleotide Polymorphism Related to Dyslipidemia in a Korean Population. | NPC1L1 rs217434 A > G as a Novel Single Nucleotide Polymorphism Related to Dyslipidemia in a Korean Population.
Cho D, Huang X, Han Y, Kim M. | 10/15/2024 |
| Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway. | Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway.
Butt E, Günder T, Stürzebecher P, Kowalski I, Schneider P, Buschmann N, Schäfer S, Bender A, Hermanns HM, Zernecke A. | 06/15/2024 |
| Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease. | Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease.
Li Y, Li J, Tang X, Xu J, Liu R, Jiang L, Tian J, Zhang Y, Wang D, Sun K, Xu B, Zhao W, Hui R, Gao R, Song L, Yuan J, Zhao X., Free PMC Article | 01/30/2024 |
| HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins. | HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins.
Li J, Tang X, Xu J, Liu R, Jiang L, Xu L, Tian J, Feng X, Wu Y, Zhang Y, Wang D, Sun K, Xu B, Zhao W, Hui R, Gao R, Song L, Yuan J, Zhao X., Free PMC Article | 06/26/2023 |
| m6A-related bioinformatics analysis and functional characterization reveals that METTL3-mediated NPC1L1 mRNA hypermethylation facilitates progression of atherosclerosis via inactivation of the MAPK pathway. | m6A-related bioinformatics analysis and functional characterization reveals that METTL3-mediated NPC1L1 mRNA hypermethylation facilitates progression of atherosclerosis via inactivation of the MAPK pathway.
Zhang G, Li X, Huang X. | 03/21/2023 |
| Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption. | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X., Free PMC Article | 04/23/2022 |
| Association of NPC1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel Disease. | Association of NPC1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel Disease.
Zhao X, Li J, Tang X, Liu R, Xu J, Xu L, Jiang L, Huang K, Tian J, Feng X, Wu Y, Zhang Y, Wang D, Sun K, Xu B, Zhao W, Hui R, Gao R, Song L, Yuan J. | 02/5/2022 |
| Expression and prognostic significance of Niemann-Pick C1-Like 1 in colorectal cancer: a retrospective cohort study. | Expression and prognostic significance of Niemann-Pick C1-Like 1 in colorectal cancer: a retrospective cohort study.
Kwon RJ, Park EJ, Lee SY, Lee Y, Hwang C, Kim C, Cho YH., Free PMC Article | 01/29/2022 |
| NPC1L1-dependent transport of 27-alkyne cholesterol in intestinal epithelial cells. | NPC1L1-dependent transport of 27-alkyne cholesterol in intestinal epithelial cells.
Ticho AL, Calzadilla N, Malhotra P, Lee H, Anbazhagan AN, Saksena S, Dudeja PK, Lee D, Gill RK, Alrefai WA., Free PMC Article | 07/31/2021 |
| The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity. | The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity.
Ferri F, Carotti S, Carpino G, Mischitelli M, Cantafora A, Molinaro A, Argenziano ME, Parisse S, Corsi A, Riminucci M, Lai Q, Mennini G, Spadetta G, Pugliese F, Rossi M, Morini S, Gaudio E, Ginanni Corradini S., Free PMC Article | 07/17/2021 |
| A new system to evaluate characteristics of Niemann-Pick C1 Like 1-mediated cholesterol transport using Xenopus laevis oocytes. | A new system to evaluate characteristics of Niemann-Pick C1 Like 1-mediated cholesterol transport using Xenopus laevis oocytes.
Nashimoto S, Yagi S, Takeda N, Nonaka M, Takekuma Y, Sugawara M, Sato Y. | 04/17/2021 |
| Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins. | Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins.
Saha P, Shumate JL, Caldwell JG, Elghobashi-Meinhardt N, Lu A, Zhang L, Olsson NE, Elias JE, Pfeffer SR., Free PMC Article | 03/20/2021 |
| Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity. | Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity.
Muku GE, Kusnadi A, Kuzu G, Tanos R, Murray IA, Gowda K, Amin S, Perdew GH., Free PMC Article | 09/26/2020 |
| Nonglucuronidated Ezetimibe Disrupts CD13- and CD64-Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages. | Nonglucuronidated Ezetimibe Disrupts CD13- and CD64-Coassembly in Membrane Microdomains and Decreases Cellular Cholesterol Content in Human Monocytes/Macrophages.
Orsó E, Robenek H, Boettcher A, Wolf Z, Liebisch G, Kramer W, Schmitz G. | 08/22/2020 |
| Hepatic NPC1L1 exacerbates diet-induced steatosis, which was accompanied by decreased hepatic ability of VLDL-TG secretion. The obtained results provide a deeper understanding of L1-Tg mice as a promising NAFLD animal model that is able to re-absorb biliary-secreted cholesterol similar to humans | Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet.
Toyoda Y, Takada T, Yamanashi Y, Suzuki H., Free PMC Article | 06/6/2020 |
| The rs2073547 polymorphism of NPC1L1 may be related to type 2 diabetes mellitus susceptibility in the Chinese population. | The Niemann-Pick C1-like 1 rs2073547 polymorphism is associated with type 2 diabetes mellitus in a Chinese population.
Huang Z, Tan R, Meng L, Yang H, Liang X, Qin Y, Luo Z., Free PMC Article | 03/21/2020 |
| Hepatic expression of human NPC1L1 resulted in an inhibition of autophagy; it may contribute to alcoholic fatty liver disease in humans. | Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice.
Wang Y, Yang P, Zhang B, Ding Y, Lei S, Hou Y, Guan X, Li Q., Free PMC Article | 02/8/2020 |
| Duodenal NPC1L1 expression was decreased in NAFLD and was negatively correlated with LXR expression in peripheral mononuclear cells. | Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease.
Ahn SB, Jun DW, Jang K, Lee BH, Shin KJ., Free PMC Article | 02/1/2020 |
| TGIF1 represses Niemann-Pick C1 like 1 (Npc1l1) promoter activity in intestines, lowering intestinal cholesterol absorption. | Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption.
Parini P, Melhuish TA, Wotton D, Larsson L, Ahmed O, Eriksson M, Pramfalk C. | 10/26/2019 |
| The variants of NPC1L1studied here had minor influence on serum noncholesterol sterolsand cholesterol metabolism. | Genetic polymorphism of sterol transporters in children with future gallstones.
Nissinen MJ, Pitkänen N, Simonen P, Gylling H, Viikari J, Raitakari O, Lehtimäki T, Juonala M, Pakarinen MP. | 02/2/2019 |
| The results obtained from liver-specific NPC1L1 transgenic mouse (L1-Tg) crossed with LDLR-/- mouse indicated no feedback mechanism to inhibit NPC1L1 function in liver and hepatic expression of NPC1L1 correlated with VLDL secretion in hypercholesterolemia state. | Hepatic NPC1L1 promotes hyperlipidemia in LDL receptor deficient mice.
Wang Y, Tang W, Yang P, Shin H, Li Q. | 10/13/2018 |
| Lifelong, genetic inhibition of NPC1L1, mimicking treatment with ezetimibe, does not associate with risk of cancer. | Using genetics to explore whether the cholesterol-lowering drug ezetimibe may cause an increased risk of cancer.
Kobberø Lauridsen B, Stender S, Frikke-Schmidt R, Nordestgaard BG, Tybjærg-Hansen A. | 08/11/2018 |
| Due to their high affinity for the N-terminal domain of NPC1L1, black and cowpea bean peptides produced in the digestive track have the potential to disrupt interactions between NPC1L1 and membrane proteins that lead to cholesterol absorption | Bean peptides have higher in silico binding affinities than ezetimibe for the N-terminal domain of cholesterol receptor Niemann-Pick C1 Like-1.
Real Hernandez LM, Gonzalez de Mejia E. | 12/2/2017 |
| These experiments demonstrate that cholesterol uptake by NPC1L1 does not require endocytosis; moreover, ezetimibe interferes with NPC1L1's cholesterol adsorption activity without blocking NPC1L1 internalization in RH7777 cells. | Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis.
Johnson TA, Pfeffer SR., Free PMC Article | 07/29/2017 |
| Novel sequencing techniques are detecting rare variants with larger effect sizes (eg, NPC1L1) , which may further improve on Cardiovascular disease risk prediction. | Impact of a Genetic Risk Score on Myocardial Infarction Risk Across Different Ethnic Populations.
Joseph PG, Pare G, Asma S, Engert JC, Yusuf S, Anand SS, INTERHEART Investigators. | 07/22/2017 |