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    SLC25A6 solute carrier family 25 member 6 [ Homo sapiens (human) ]

    Gene ID: 293, updated on 5-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration.

    Dosage of the pseudoautosomal gene SLC25A6 is implicated in QTc interval duration.
    Skakkebæk A, Kjær-Sørensen K, Matchkov VV, Christensen LL, Just J, Cömert C, Andersen NH, Oxvig C, Gravholt CH., Free PMC Article

    07/31/2023
    Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.

    Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.
    Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI., Free PMC Article

    11/6/2021
    Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.

    Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.
    Trisolini L, Laera L, Favia M, Muscella A, Castegna A, Pesce V, Guerra L, De Grassi A, Volpicella M, Pierri CL., Free PMC Article

    06/26/2021
    cancer cells require both hANT2 and hANT3, depending on their proliferation status: hANT2 when proliferation rates are high, and hANT3 when proliferation slows.

    Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.
    Gavaldà-Navarro A, Mampel T, Viñas O., Free PMC Article

    11/5/2016
    Human ANT3 expression is directly downregulated by overexpression of hcmv-miR-UL36-5p.

    Human cytomegalovirus miR-UL36-5p inhibits apoptosis via downregulation of adenine nucleotide translocator 3 in cultured cells.
    Guo X, Huang Y, Qi Y, Liu Z, Ma Y, Shao Y, Jiang S, Sun Z, Ruan Q.

    01/16/2016
    Compares and contrasts all the known human SLC25A* genes and includes functional information.

    The mitochondrial transporter family SLC25: identification, properties and physiopathology.
    Palmieri F.

    07/2/2013
    The dynamics of the molecular interactions between the C-terminal region of PB1-F2 protein and VDAC1 and ANT3 were expounded by employing an in silico approach.

    Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach.
    Danishuddin M, Khan SN, Khan AU.

    05/3/2010
    These data suggest that the down-regulation of ANT3 levels upon stimulation with CPT may be involved in the molecular mechanism underlying acquired resistance to camptothecin.

    Down-regulation of adenine nucleotide translocase 3 and its role in camptothecin-induced apoptosis in human hepatoma QGY7703 cells.
    Hu Z, Guo X, Yu Q, Qiu L, Li J, Ying K, Guo C, Zhang J.

    01/21/2010
    involvement of ANT in cell death is cell type- and stimulus-dependent

    Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells.
    Yang Z, Cheng W, Hong L, Chen W, Wang Y, Lin S, Han J, Zhou H, Gu J., Free PMC Article

    01/21/2010
    ANT3 overexpression induces apoptosis in cultured cells.

    Adenine nucleotide translocase 3 (ANT3) overexpression induces apoptosis in cultured cells.
    Zamora M, Granell M, Mampel T, Viñas O.

    01/21/2010
    Results demonstrate that induction of adenine nucleotide translocase 3 by interleukin-4 and interferon-gamma proceeds via pathways involving STAT6 and STAT1, respectively.

    Mitochondrial adenine nucleotide translocator 3 is regulated by IL-4 and IFN-gamma via STAT-dependent pathways.
    Jang JY, Lee CE.

    01/21/2010
    ANT3 has a potential role in T-helper cell survival and immune cell homeostasis.

    IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis.
    Jang JY, Lee CE.

    01/21/2010
    Of three ANT isoforms expressed in yeast, ANC3 is the most efficient to restore yeast growth on a nonfermentable carbon source of a yeast mutant strain lacking its three endogenous ANC.

    The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.
    De Marcos Lousa C, Trézéguet V, Dianoux AC, Brandolin G, Lauquin GJ.

    01/21/2010
    Results revealed that ANT1 and ANT3 (adenine nucleotide translocase 1-3) over-expressing HeLa cells increased their atRA sensitivity.

    Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid.
    Zamora M, Ortega JA, Alaña L, Viñas O, Mampel T.

    01/21/2010
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