| GRSF1 deficiency attenuates mitochondrial function in aging granulosa cells. | GRSF1 deficiency attenuates mitochondrial function in aging granulosa cells.
Wen C, Jiang L, Pan P, Huang J, Xie Y, Ou S, Li Y. | 06/30/2024 |
| GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability. | GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability.
Liu D, Xu C, Gong Z, Zhao Y, Fang Z, Rao X, Chen Q, Li G, Kong W, Chen J., Free PMC Article | 11/8/2023 |
| GRSF1 promotes tumorigenesis and EMT-mediated metastasis through PI3K/AKT pathway in gastric cancer. | GRSF1 promotes tumorigenesis and EMT-mediated metastasis through PI3K/AKT pathway in gastric cancer.
Wang B, Wang L, Lu Y, Liang W, Gao Y, Xi H, Chen L. | 07/3/2021 |
| Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1. | Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.
Dumoulin B, Ufer C, Stehling S, Heydeck D, Kuhn H, Sofi S. | 01/9/2021 |
| GRSF1 is an age-related regulator of senescence. | GRSF1 is an age-related regulator of senescence.
Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P., Free PMC Article | 10/31/2020 |
| A novel miRNA identified in GRSF1 complex drives the metastasis via the PIK3R3/AKT/NF-kappaB and TIMP3/MMP9 pathways in cervical cancer cells. | A novel miRNA identified in GRSF1 complex drives the metastasis via the PIK3R3/AKT/NF-κB and TIMP3/MMP9 pathways in cervical cancer cells.
Sun Q, Yang Z, Li P, Wang X, Sun L, Wang S, Liu M, Tang H., Free PMC Article | 09/12/2020 |
| our results indicate that GRSF1 helps preserve mitochondrial homeostasis, in turn preventing oxidative DNA damage and the activation of mTOR and NF-kappaB, and suppressing a transcriptional pro-inflammatory program leading to increased IL6 production. | Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program.
Noh JH, Kim KM, Pandey PR, Noren Hooten N, Munk R, Kundu G, De S, Martindale JL, Yang X, Evans MK, Abdelmohsen K, Gorospe M., Free PMC Article | 10/19/2019 |
| These findings suggest that Twinkle is essential for RNA organization in granules, and that mtSSB is involved in the recently proposed GRSF1-mtRNA degradosome pathway, a route suggested to be particularly aimed at degradation of G-quadruplex prone long non-coding mtRNAs. | Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB.
Hensen F, Potter A, van Esveld SL, Tarrés-Solé A, Chakraborty A, Solà M, Spelbrink JN., Free PMC Article | 10/12/2019 |
| These findings indicate that the decline in GRSF1 levels during cellular senescence contributes to impairing mitochondrial function, elevating ROS and DNA damage, suppressing growth, and implementing a pro-inflammatory program. | GRSF1 suppresses cell senescence.
Noh JH, Kim KM, Idda ML, Martindale JL, Yang X, Abdelmohsen K, Gorospe M., Free PMC Article | 10/5/2019 |
| GRSF1 positively regulates degradosome-dependent decay of non-coding mitochondrial transcripts that form G4 structures. Comprehensive molecular analyses revealed that GRSF1 melts G4 RNA structures in mtRNAs, which facilitates their degradation by the hSuv3-PNPase complex both in vitro and in vivo. | Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.
Pietras Z, Wojcik MA, Borowski LS, Szewczyk M, Kulinski TM, Cysewski D, Stepien PP, Dziembowski A, Szczesny RJ., Free PMC Article | 01/19/2019 |
| Data show that some of the naturally occurring guanine-rich RNA sequence binding factor 1 (GRSF1) mutants exhibited a strongly reduced RNA-binding activity although the general protein structure was hardly affected. | Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1).
Sofi S, Fitzgerald JC, Jähn D, Dumoulin B, Stehling S, Kuhn H, Ufer C. | 04/28/2018 |
| Deletion of either of the three GRSF1 quasi-RNA-recognition motifs (qRRMs) severely impairs RNA-binding. | Functional characterization of isolated RNA-binding domains of the GRSF1 protein.
Sofi S, Stehling S, Niewienda A, Janek K, Kuhn H, Ufer C. | 04/28/2018 |
| HuR and GRSF1 govern the cytoplasmic and mitochondrial localization of the lncRNA RMRP, which is encoded by nuclear DNA but has key functions in mitochondria. | HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP.
Noh JH, Kim KM, Abdelmohsen K, Yoon JH, Panda AC, Munk R, Kim J, Curtis J, Moad CA, Wohler CM, Indig FE, de Paula W, Dudekula DB, De S, Piao Y, Yang X, Martindale JL, de Cabo R, Gorospe M., Free PMC Article | 02/25/2017 |
| MiR-346 depends on GRSF1 to upregulate another target gene. | miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively.
Song G, Wang R, Guo J, Liu X, Wang F, Qi Y, Wan H, Liu M, Li X, Tang H., Free PMC Article | 08/6/2016 |
| Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site. | Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.
Nieradka A, Ufer C, Thiadens K, Grech G, Horos R, van Coevorden-Hameete M, van den Akker E, Sofi S, Kuhn H, von Lindern M., Free PMC Article | 05/30/2015 |
| GRSF1 regulates RNA processing in mitochondrial RNA granules. | GRSF1 regulates RNA processing in mitochondrial RNA granules.
Jourdain AA, Koppen M, Wydro M, Rodley CD, Lightowlers RN, Chrzanowska-Lightowlers ZM, Martinou JC., Free PMC Article | 08/31/2013 |
| The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression. | The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.
Antonicka H, Sasarman F, Nishimura T, Paupe V, Shoubridge EA. | 08/31/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| GRSF-1 functions by selectively recruiting cellular and viral mRNAs containing 5' UTR GRSF-1 binding sites to polyribosomes, which is mediated through interactions with cellular proteins | Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis.
Kash JC, Cunningham DM, Smit MW, Park Y, Fritz D, Wilusz J, Katze MG., Free PMC Article | 01/21/2010 |